Medicinal application of resveratrol

A technology of resveratrol and medicine, applied in the field of medicinal use of resveratrol, can solve the problems of hyperthyroidism, hyperthyroidism, difficult dosage control, etc., to improve depression-related behavior and improve learning and memory ability , Improve the effect of hypothalamic-pituitary-thyroid axis function

Inactive Publication Date: 2016-01-27
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thyroid hormone replacement therapy is the main clinical treatment for hypothyroidism, but there are disadvantages

Method used

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  • Medicinal application of resveratrol
  • Medicinal application of resveratrol
  • Medicinal application of resveratrol

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Experimental program
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Embodiment Construction

[0019] The following will combine specific pharmacological experiments and results to further explain how resveratrol can improve the unbalanced hypothalamus-pituitary-thyroid axis function in patients with hypothyroidism, improve the learning and memory ability of patients with hypothyroidism, and improve their depression-related behaviors role in.

[0020] 1. Effects of resveratrol on the hypothalamus-pituitary-thyroid axis in rats with hypothyroidism:

[0021] The model of hypothyroidism in rats was established by unilateral thyroid electrocoagulation, and the drug was administered 2 weeks after the operation and continued for 3 weeks. The concentrations of total T3, free T4 (fT4) and thyroid-stimulating hormone (TSH) in rat plasma were determined by radioimmunoassay, and the expression of thyrotropin-releasing hormone (TRH) in rat hypothalamus was detected by real-time fluorescent quantitative PCR. The results are shown in Table 1 and figure 1 , compared with the sham op...

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Abstract

The invention discloses application of resveratrol to preparing medicines for treating sub-clinical hypothyroidism and neuropsychiatric syndromes due to the sub-clinical hypothyroidism. The application has the advantages that the resveratrol is applied to preparing the medicines for treating the sub-clinical hypothyroidism and the neuropsychiatric syndromes due to the sub-clinical hypothyroidism, accordingly, imbalance hypothalamus-pituitary-thyroid axis functions of sub-clinical hypothyroidism patients can be improved, the learning and memory ability of the sub-clinical hypothyroidism patients can be enhanced, and depression-related behavior of the sub-clinical hypothyroidism can be improved.

Description

technical field [0001] The invention relates to a medicinal use of resveratrol, in particular to the application of resveratrol in the preparation of medicines for treating subclinical hypothyroidism and the psychoneural symptoms caused by it. Background technique [0002] Subclinical hypothyroidism (hereinafter referred to as hypothyroidism) refers to a mild decrease in thyroid hormone secretion due to thyroid hormone synthesis or release disorders, and its laboratory tests show a slight increase in serum thyroid stimulating hormone (TSH) levels High, but the serum free thyroxine (fT4) and triiodothyronine (triiodothyronine, T3) levels are normal, clinically often regarded as mild clinical hypothyroidism (hereinafter referred to as hypothyroidism) or clinical thyroid Early manifestations of reduction. The prevalence of hypothyroidism is 4-10%, and it is as high as 7-26% in the elderly population. Although the level of thyroid hormone in the peripheral blood of patients wi...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P5/14A61P25/28A61P25/24
Inventor 葛金芳徐亚运陈征陈飞虎李俊
Owner ANHUI MEDICAL UNIV
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