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Cornea protective agent as well as preparation method and application thereof

A protective agent, cornea technology, applied in the field of medicine, can solve the problems of patient discomfort, short time for moisturizing the cornea, etc., to achieve the effect of improving comfort, good protection, and reducing complications

Pending Publication Date: 2022-01-04
TIANJIN JINGMING NEW TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ophthalmic Balanced Salt Solution (BSS) is the most commonly used corneal wetting agent. Since Ophthalmic Balanced Salt Solution is easy to evaporate and the time for moisturizing the cornea is very short, it is necessary to repeatedly rinse the corneal surface during the operation. Repeated irrigation will not only make the patient feel uncomfortable Discomfort, and additional work for surgeons and assistants

Method used

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  • Cornea protective agent as well as preparation method and application thereof
  • Cornea protective agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The production method is:

[0028] 1. Prepare buffer:

[0029] Weigh 0.60g of NaCl, 0.15g of KCl, 0.05g of MgCl respectively 2 , 0.07g of CaCl 2 , 0.5g of C 2 h 3 o 2Na, 0.35g of C 6 h 5 o 7 Na 3 , dissolved in 100ml of water for injection to prepare buffer solution A, in the buffer solution, add levofloxacin powder to a final concentration of 2mg / ml, tobramycin powder to a final concentration of 1mg / ml, and dexamethasone stock solution to a final concentration of 0.5mg / ml, and stir After the above-mentioned raw materials are completely dissolved, buffer solution B is obtained, and buffer solution B is sterilized by filtration with a 0.22 micron filter membrane.

[0030] 2. Weigh 1.5 g of hydroxypropyl methylcellulose with a viscosity of 3,000 mPa·s and 0.4 g of chondroitin sulfate with a molecular weight of 20,000, dissolve them in 100 ml of the buffer solution obtained in the previous step, and sterilize under high pressure at 121°C for 40 Minutes, then sub-...

Embodiment 2

[0033] 1. Use the method in Example 1 to make a buffer, weigh 2.0 g of hydroxypropyl methylcellulose with a viscosity of 2,000 mPa s, and 1.0 g of chondroitin sulfate with a molecular weight of 10,000 and dissolve them in 100 ml of buffer , autoclaved at 121° C. for 40 minutes, and then dispensed into disposable containers to obtain corneal protective agent 2.

[0034] 2. With 24 (48 eyes) New Zealand white rabbits for scientific research, adopt the method of random control, select the right eye (24 eyes) as the experimental group, and the left eye (24 eyes) as the control group, and the experimental group performs cataract extraction under the operating microscope During the operation, 2 points of corneal protective agent were applied to the eyes. The control group underwent cataract extraction under the operating microscope. Statistical analysis was performed on the data of the experimental group and the control group by T test, and Pfigure 1 ) (P<0.05).

Embodiment 3

[0036] 1. Use the method in Example 1 to make a buffer, weigh 1.0 g of hydroxypropyl methylcellulose with a viscosity of 4,000 mPa s, and 0.2 g of chondroitin sulfate with a molecular weight of 30,000 and dissolve them in 100 ml of buffer , autoclaved at 121°C for 40 minutes, and then dispensed into disposable containers to obtain corneal protective agent 3.

[0037] 2. Using 16 New Zealand white rabbits (32 eyes) for scientific research, adopt the method of random control, select the right eye (16 eyes) as the experimental group, and the left eye (16 eyes) as the control group, and the experimental group performs cataract extraction under the operating microscope During the operation, corneal protective agent was applied to the eyes for 3 times. The control group underwent cataract extraction under the operating microscope, and the eyes were injected with ophthalmic balanced salt solution during the operation. The changes in the density of epithelial cells in the upper and cen...

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Abstract

The invention provides a cornea protective agent. The cornea protective agent comprises hydroxypropyl methyl cellulose with the viscosity of 5mPa.S to 200,000 mPa.S and / or chondroitin sulfate with the molecular weight of 20,000 to 500,000, an anti-inflammatory substance and a buffer solution. The cornea protective agent disclosed by the invention can protect the cornea surface in an operation, can keep the cornea surface moist within a certain time and keep good transparency of the cornea, and provides a good operation visual field. Meanwhile, the risk of postoperative corneal epithelium dysfunction can be reduced, and postoperative complications are reduced.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to a corneal protectant and its preparation method and use. Background technique [0002] Because eyelid speculum is used to prevent eye closure during ophthalmic surgery, it is often necessary to use corneal wetting agent as a substitute for tear film to maintain the hydration of corneal epithelial cells and provide a clear surgical field of view. Ophthalmic Balanced Salt Solution (BSS) is the most commonly used corneal wetting agent. Since Ophthalmic Balanced Salt Solution is easy to evaporate and the time for moisturizing the cornea is very short, it is necessary to repeatedly rinse the corneal surface during the operation. Repeated irrigation will not only make the patient feel uncomfortable Discomfort, but also bring extra work to the surgeon and assistants. [0003] The use of the currently disclosed preservation solution is mainly to preserve th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/717A61K9/08A61K9/00A61P27/02A61P29/00A61K31/5383A61K31/702A61K31/573
CPCA61K31/737A61K31/717A61K31/5383A61K31/702A61K31/573A61K9/08A61K9/0048A61P27/02A61P29/00A61K2300/00
Inventor 黄丽娟肖光礼白鹏
Owner TIANJIN JINGMING NEW TECH DEV CO LTD
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