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Multifunctional corneal graft piece

A multifunctional, corneal technology, applied in eye implants and other directions, can solve the problems of low success rate of corneal transplantation and lack of corneal donors, and achieve the effect of easy processing, diverse structure and good biocompatibility

Active Publication Date: 2019-06-21
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corneal transplantation is the only way to restore sight to blind patients, but there is a severe shortage of corneal donors
[0003] In some special cases, such as corneas with severe chemical and thermal burns, corneas with repeated corneal transplant failures, corneas with severe dry eye, petechiae, etc., the surgical success rate of corneal transplantation is extremely low

Method used

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  • Multifunctional corneal graft piece
  • Multifunctional corneal graft piece
  • Multifunctional corneal graft piece

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Embodiment Construction

[0028] Embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary and not intended to limit the scope of the invention and its application.

[0029] refer to Figure 1a to Figure 2b , in some embodiments, a multifunctional corneal graft 11 (13), comprising a plurality of sheet bodies 1-1, 1-2 (1-3, 1-4) formed in blocks, the plurality of Sheets 1-1, 1-2, (1-3, 1-4) are spliced ​​into the corneal graft 11 (13), each sheet 1-1, 1-2 (1-3, 1-4 ) contains releasable pharmaceutical factors or biological factors with the same or different functions.

[0030] In a specific embodiment, the drug factors contained in each sheet body 1-1, 1-2 (1-3, 1-4) formed in blocks may include anti-inflammatory factors, etc., and each sheet body 1-2 (1-3, 1-4) formed in blocks 1. The biological factors contained in 1-2 (1-3, 1-4) may include proteins, cells or growth factors and the like.

[0031] Such as Figur...

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Abstract

The invention discloses a multifunctional corneal graft piece, which contains releasable drug factors or biological factors with the same or different functions in the corneal graft piece body in a manner of blocking, layering, dividing regions or dividing different chambers, different regions / positions of the corneal graft piece can carry different kinds of drugs to prevent and treat multiple corneal diseases, and different or synergistic prevention and treatment effects can be realized in different regions / positions of the same corneal graft piece. The corneal graft piece achieves versatility by carrying multiple factors or proteins in different regions / positions of the corneal graft piece. By the arrangement of corresponding parts of the corneal graft piece, fixed-point quantitative drug factor release can be realized to prevent and treat inflammation. The multifunctional corneal graft piece has multiple structures, is easy to process, has good biocompatibility, and can well play arole in preventing and treating diseases.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a multifunctional corneal graft. Background technique [0002] Corneal disease is the second leading cause of blindness after cataracts. Corneal clouding is one of the leading causes of bilateral blindness, affecting 7 million people worldwide. Of these, 2.85 million had reduced or no sensation due to corneal nerve dysfunction or degeneration. Corneal transplantation is the only way to restore sight to blind patients, but there is a severe shortage of corneal donors. [0003] In some special cases, such as corneas with severe chemical and thermal burns, corneas with repeated corneal transplant failures, corneas with severe dry eye, and petechiae, etc., the success rate of corneal transplantation is extremely low. It is extremely important and urgent to develop an artificial corneal graft that can carry different kinds of drugs to prevent and treat inflammation. Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14
Inventor 弥胜利王杰琼
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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