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Therapeutic agent for corneal disease

Inactive Publication Date: 2009-01-29
TEIKA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The therapeutic agent of a corneal disease of the present invention has an effect of significantly promoting a cure of corneal diseases, particularly cure of disorders in the anterior epithelium of cornea.

Problems solved by technology

There is a limitation, however, in their therapeutic effect, and further it could not be said that they fundamentally cure the corneal disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Therapeutic Agent-1 for a Corneal Disease

Component

[0019]

Irsogladine maleate0.1 g  Polysorbate 802 gEthanol5 gPhysiological salineBalance to total 100 mL

(Method of Preparation)

[0020]Irsogladine maleate was dissolved in ethanol, and polysorbate 80 was added to the solution. Then, physiological saline was added to the mixture to obtain 100 mL of a therapeutic agent for a corneal disease as an ophthalmic solution.

example 2

Therapeutic Agent-2 for a Corneal Disease

Component

[0021]

Irsogladine maleate0.3 g  Polysorbate 805 gEthanol5 gPhysiological salineBalance to total 100 mL

(Method of Preparation)

[0022]Irsogladine maleate was dissolved in ethanol, and polysorbate 80 was added to the solution. Then, physiological saline was added to the mixture to obtain 100 mL of a therapeutic agent for a corneal disease as an ophthalmic solution.

example 3

Oily-Based Ophthalmic Solution

Component

[0023]

Irsogladine maleate 0.3 gCastor oil99.7 g

(Method of Preparation)

[0024]Irsogladine maleate was mixed with castor oil in a conventional manner to obtain a therapeutic agent for a corneal disease as an oily-based ophthalmic solution.

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Abstract

A therapeutic agent for a corneal disease comprising irsogladine or a salt thereof as an active ingredient. The purpose is to find a substance capable of effectively treating / ameliorating a corneal disease which has been increased in the number of cases thereof in recent years and to provide a therapeutic agent for a corneal disease comprising the substance as an active ingredient.

Description

TECHNICAL FIELD[0001]The present invention relates to a therapeutic agent for a corneal disease, and more particularly, it relates to a therapeutic agent for a corneal disease applicable to a disorder in the anterior epithelium of cornea, particularly in a formulation of ophthalmic solutions.BACKGROUND ART[0002]Disorder in the anterior epithelium of cornea can be classified roughly into 4 types, that is, (1) one caused by an inflammation such as infection, (2) hereditary disease, (3) exogenous physical injury and chemical injury caused by chemicals, and (4) nutritional disorder.[0003]Among them, there is a tendency for corneal diseases to increase in recent years due to physical injury accompanied by lacrimal hyposecretion (so-called dry-eye) with the spread of personal computers and contact lens, and those caused by pollinosis, particularly disorder in the anterior epithelium; thus, a drug effective to corneal diseases or disorders in the anterior epithelium of cornea has been dema...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61P27/02
CPCA61K9/0048C07D251/18A61K31/53A61P27/02
Inventor KIMURA, TAKAHITOFUJISHITA, SHIGETOKAWADA, HIROYOSHI
Owner TEIKA PHARMA CO LTD
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