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Bone tissue rack of TiO2 reinforced polyhydroxyethyl methacrylate and its prepn process

A polyhydroxyethyl methacrylate and bone tissue technology, applied in the field of bone tissue scaffolds and their preparation, can solve problems such as adverse effects on cell activity, and achieve the effects of improving mechanical properties and enhancing strength

Inactive Publication Date: 2007-03-07
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the defects that the acidic degradation products of the existing degradable scaffold materials may have adverse effects on the activity of cells, and at the same time, its hydrophilicity, cytocompatibility, mechanical strength, etc. need to be improved, and provide a Kind of TiO 2 Nanoparticle-reinforced macroporous pHEMA bone tissue scaffold, which is composed of polyhydroxyethylmethacrylate (pHEMA), TiO 2 Nanoparticles and hydroxyapatite (Ca 5 (PO 4 ) 3 (OH), HA) composition, adding mass percentage of 1 to 20% TiO in polyhydroxyethyl methacrylate 2 Nanoparticles form a scaffold material, and a 1-10 μm layer of hydroxyapatite is deposited on the inner and outer surfaces of the scaffold material

Method used

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  • Bone tissue rack of TiO2 reinforced polyhydroxyethyl methacrylate and its prepn process
  • Bone tissue rack of TiO2 reinforced polyhydroxyethyl methacrylate and its prepn process

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specific Embodiment approach 1

[0015] Specific embodiment one: as shown in Figure 1 and 2, the TiO of embodiment 2 Nanoparticle-reinforced macroporous pHEMA bone tissue scaffold made of polyhydroxyethylmethacrylate 1, TiO 2 Composed of nanoparticles 2 and hydroxyapatite 3, TiO is added to polyhydroxyethylmethacrylate 1 2 The nanoparticles 2 form a scaffold material, and a layer 3 of hydroxyapatite is deposited on the inner and outer surfaces of the scaffold material. The polyhydroxyethyl methacrylate described in this embodiment has a three-dimensional interconnected macroporous structure, the pore diameter ranges from 100 to 1000 μm, and the porosity is above 70%; TiO 2 The size of the nanoparticles is 10-50nm, and the mass percentage added is 1-20%; the thickness of the hydroxyapatite layer is 1-10 μm.

specific Embodiment approach 2

[0016] Specific embodiment two: this embodiment prepares TiO according to the following steps 2 Nanoparticle-enhanced macroporous pHEMA bone tissue scaffold: a. Three-dimensional porous poly(hydroxyethyl methacrylate) was prepared by photocrosslinking salt leaching method, and TiO was added 2 nanoparticles, to obtain TiO 2 Nanoparticle-reinforced three-dimensional interconnected macroporous poly(hydroxyethyl methacrylate) bone tissue scaffold material; b, TiO 2 The nanoparticle-reinforced three-dimensional interconnected macroporous poly(hydroxyethyl methacrylate) bone tissue scaffold material was immersed in hydroxyapatite hydrochloric acid solution containing urea, the pH value of the solution was 1-5, and the solution was gradually heated from room temperature to 90-100 ℃, control the heating rate to 0.1-0.5℃ / min, without stirring; c, then carry out mineralization treatment under the condition of 95-100℃, and obtain TiO with a thickness of 1-10μm hydroxyapatite layer depos...

specific Embodiment approach 3

[0018] Specific embodiment three: this embodiment prepares TiO according to the following steps 2 Nanoparticle-enhanced macroporous pHEMA bone tissue scaffold: a. Poly(hydroxyethyl methacrylate) with macroporous structure was prepared by sol-gel method, and then TiO was added 2 Nanoparticles, TiO2 prepared by melt-shaping particulate leaching 2 Nanoparticle-reinforced three-dimensional interconnected macroporous poly(hydroxyethyl methacrylate) bone tissue scaffold material; b, TiO 2 The nanoparticle-reinforced three-dimensional interconnected macroporous poly(hydroxyethyl methacrylate) bone tissue scaffold material was immersed in hydroxyapatite hydrochloric acid solution containing urea, the pH value of the solution was 1-5, and the solution was gradually heated from room temperature to 90-100 ℃, control the heating rate to 0.1-0.5℃ / min, without stirring; c, then carry out mineralization treatment under the condition of 95-100℃, and obtain TiO with a thickness of 1-10μm hydr...

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Abstract

The present invention has bone tissue rack comprising pHEMA, nanometer TiO2 particle and HA, pHEMA with added nanometer TiO2 particle forms the rack, and HA layers are deposited onto the inner and the outer surfaces. The preparation process of the bone tissue rack includes: preparing the rack material via photo cross-linking and salt leaching method or melting to form and particle leaching method; soaking the rack material inside HA salt solution with urea and heating; and mineralizing treatment. The bone tissue rack of the present invention has no teratogenic, cancerogenic and other bad reactions, no toxic side effect, no pHEMA degradation, and no influence on cell activity.

Description

technical field [0001] The invention relates to a bone tissue scaffold and a preparation method thereof, in particular to a TiO that can be used for the repair and replacement of bone defects caused by various reasons 2 Nanoparticle-enhanced macroporous poly(hydroxyethylmethacrylate) bone tissue scaffold and its preparation method. Background technique [0002] The incidence of bone defects caused by various reasons is relatively high, and the most common treatment method is to implant artificial bone scaffold materials, generally three-dimensional porous materials. Three-dimensional scaffold materials for bone tissue engineering should meet the following requirements: (1) have good biocompatibility and biodegradability; (2) have conductivity, which is conducive to cell adhesion and proliferation; (3) have certain Strength, can resist external force; (4) easy to shape, can be processed into various shapes and sizes according to needs. Considering the problem that tradition...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/56
Inventor 郑玉峰李莉徐晓雪李超
Owner HARBIN ENG UNIV
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