A method for improving the hydrophilicity and flexibility of a polypeptide film with polyurethane and polyhydroxyethyl methacrylate

A polyhydroxyethyl methacrylate and polyurethane technology, which is applied in the field of polymer film preparation, can solve problems such as unreported, easy to grasp, and improve the hydrophilicity and flexibility of the polypeptide modified film. , the effect of simple operation

Inactive Publication Date: 2016-09-21
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity and flexibility of the polypeptide film with polyurethane and polyhydroxyethyl methacrylate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups

[0017] Add 5.5 grams of 2,4-toluene diisocyanate and 17.2 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 353 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 40°C for 45 minutes, then added 0.81 g of 1,4-butanediol and reacted for 10 minutes, then added 1.22 g of 3-hydroxypropionic acid and reacted for 5 minutes to terminate the reaction and obtain the target thing;

[0018] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer

[0019] Add 16.1 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 9 g of polyurethane containing terminal -COOH groups into the dry reactor, add 308 ml of dimethyl formamide, add another 0.046 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated the reaction, filtered, dialyzed, and dried t...

Embodiment 2

[0024] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups

[0025] Add 6.05 grams of 2,4-toluene diisocyanate and 19 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 355 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 45°C for 47 minutes, then added 0.88 g of 1,4-butanediol to react for 12 minutes, then added 1.32 g of 3-hydroxypropionic acid to react for 7 minutes, and terminated the reaction to obtain the target thing;

[0026] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer

[0027] Add 16.5 g of poly(r-ethyl-L-glutamate) (molecular weight: 85,000) and 9 g of polyurethane containing terminal -COOH groups into the dry reactor, add 313 ml of dimethylformaldehyde Amide, add 0.028 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the targe...

Embodiment 3

[0032] 1) Synthesis of Polyurethanes Containing Terminal -COOH Groups

[0033] Add 6.6 grams of 2,4-toluene diisocyanate and 21 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 362 ml of dimethylformamide solvent, and add di Dibutyltin laurate, under an inert atmosphere, stirred and reacted at 50°C for 50 minutes, then added 0.92 g of 1,4-butanediol to react for 15 minutes, then added 1.84 g of 3-hydroxypropionic acid to react for 10 minutes, terminated the reaction, and obtained the target thing;

[0034] 2) Synthesis of Polypeptide-Polyurethane Block Copolymer

[0035] Add 16.8 g of poly(r-methyl-L-glutamate) (molecular weight: 90,000) and 9.9 g of polyurethane containing terminal -COOH groups into the dry reactor, add 316 ml of dimethylformaldehyde Amide, then add 0.046 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir and react at 35°C for 3 days, then terminate the reaction, filter, dialyze, ...

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PUM

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Abstract

The present invention discloses a method of polymethyl -aminate and polymethyl acrylic hydroxyl ethyl to improve the hydrophilicity and softness of polypeptide membrane.Alcohol, catalyst and solvents, in an inert atmosphere, react for a period of time, add butanol response for a period of time, and then add 3‑ hydroxyl propyate reactions, which may contain polymethyl acid ester with endboxyl group;Polymethytate, solvents, sync, and polypeptides of the polymeramine containing carboxyl groups, in an inert atmosphere, reacts for 2 to 3 days, and the polypeptide polyethylemate embedded segment; 3) in the dry reactionThe polypeptide polyacramine is added to the polypenicate, polymethylene acrylic hydroxyl ethyl ethyl, and solvents. In an inert atmosphere, mix for a period of time to form a film and dry with a flowing method.The preparation process of the present invention is simple, and the hydrophilicity and softness of the transformer membrane have greatly improved.

Description

Technical field [0001] The present invention involves a polymethytic acid ester and polymethyl acrylic hydroxyl ethyl to improve the hydrophilicity and softness of polypeptide membrane, which belongs to the field of polymer thin film preparation technology. Background technique [0002] Polypeptide is a good biocompatibility and biodegradable biological material. The polypeptide membrane can be used as artificial skin, but the polypeptide membrane is relatively stiff and lacks hydrophilicity, which has a certain degree of limitations.application.Poly aminotamate has good biocompatibility and degradability of biochemicals, softened and has good compatibility with polymethyl hydroxyl ethyl.Polyetic acrylic hydroxyl ethyl has good biocompatibility and degradable biodegradability, and has good hydrophilicity.First introduce the polybinosate chain segment to the polypeptide chain segment to form a polypeptide-polyamate composite section of the polypenicide segment to improve the coexi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00C08L87/00C08L33/14C08J5/18C08G18/66C08G18/48C08G18/34
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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