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A kind of hydrogel dressing and preparation method thereof

A hydrogel and carrageenan technology, applied in medical science, bandages, absorbent pads, etc., can solve the problem of inconvenient observation of wound healing, and achieve good tensile properties and biocompatibility, long-term antibacterial effect, The effect of enhancing tensile strength

Active Publication Date: 2016-10-12
南京竹海生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, although the commercially available hydrogel wound dressings solve the problems of absorbing exudate, air permeability, blocking bacteria, waterproofing, and wound comfort, in order to increase the strength of the hydrogel, strengthen the hydrogel and the waterproof and breathable back For the adhesiveness of the film, most fiber fabrics or non-woven fabrics are used as the reinforcement layer, and a complex multi-layer composite process is adopted, so that the resulting product is an opaque structure, which is not easy to observe the wound healing

Method used

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  • A kind of hydrogel dressing and preparation method thereof
  • A kind of hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A hydrogel dressing, comprising in parts by weight: 2 parts of seabuckthorn extract, 1 part of herb extract, 3 parts of hyaluronic acid, 0.5 part of polylysine, 3 parts of polyhydroxyethyl methacrylate, carrageenan 2 parts, 1 part of 2-hydroxyethyl methacrylate, 0.8 parts of vitamin C, 1 part of polyvinyl alcohol, 2 parts of calcium chloride, 1 part of borax, 0.7 parts of ammonium dihydrogen phosphate, 2 parts of glycerin, 3 parts of mannose parts, 20 parts of deionized water.

[0025] The above seabuckthorn extract is seabuckthorn proanthocyanidin; the herb extract is the volatile oil of herb; the degree of polymerization of polyvinyl alcohol is 1000, and the degree of alcoholysis is 80%.

[0026] The preparation method of above-mentioned hydrogel dressing comprises the following steps:

[0027] Step 1: prepare seabuckthorn extract, dry and pulverize seabuckthorn leaves, add absolute ethanol to the powder and heat under reflux at 60°C for extraction, suction filter th...

Embodiment 2

[0033] A hydrogel dressing, comprising in parts by weight: 3 parts of seabuckthorn extract, 2 parts of herb extract, 5 parts of hyaluronic acid, 1.2 parts of polylysine, 8 parts of polyhydroxyethyl methacrylate, carrageenan 6 parts, 3 parts of 2-hydroxyethyl methacrylate, 1.5 parts of vitamin C, 2 parts of polyvinyl alcohol, 4 parts of calcium chloride, 2 parts of borax, 0.9 parts of ammonium dihydrogen phosphate, 4 parts of glycerin, 6 parts of mannose parts, 30 parts of deionized water.

[0034] The above seabuckthorn extract is seabuckthorn proanthocyanidin; the herb extract is the volatile oil of herb; the degree of polymerization of polyvinyl alcohol is 3000, and the degree of alcoholysis is 80%.

[0035] The preparation method of above-mentioned hydrogel dressing comprises the following steps:

[0036] Step 1: prepare seabuckthorn extract, dry and pulverize seabuckthorn leaves, add absolute ethanol to the powder and heat under reflux at 60°C for extraction, suction filt...

Embodiment 3

[0042] A hydrogel dressing, comprising in parts by weight: 5 parts of seabuckthorn extract, 2 parts of herb extract, 7 parts of hyaluronic acid, 1.5 parts of polylysine, 9 parts of polyhydroxyethyl methacrylate, carrageenan 7 parts, 5 parts of 2-hydroxyethyl methacrylate, 2.2 parts of vitamin C, 5 parts of polyvinyl alcohol, 4 parts of calcium chloride, 3 parts of borax, 1.2 parts of ammonium dihydrogen phosphate, 6 parts of glycerin, 5 parts of mannose parts, 35 parts of deionized water.

[0043] The above seabuckthorn extract is seabuckthorn proanthocyanidin; the herb extract is the volatile oil of herb; the degree of polymerization of polyvinyl alcohol is 1000, and the degree of alcoholysis is 80%.

[0044] The preparation method of above-mentioned hydrogel dressing comprises the following steps:

[0045] Step 1: prepare seabuckthorn extract, dry and pulverize seabuckthorn leaves, add absolute ethanol to the powder and heat under reflux at 60°C for extraction, suction filt...

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Abstract

The invention provides a hydrogel dressing and a preparation method thereof. The dressing is prepared from a sea-buckthorn extract, a Chinese atractylode rhizome extract, hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate, vitamin C, polyvinyl alcohol, calcium chloride, borax, ammonium dihydrogen phosphate, glycerinum, mannose and deionized water. The preparation method comprises the following steps: firstly preparing the sea-buckthorn extract and the Chinese atractylode rhizome extract, respectively, adding such components as hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate and ammonium dihydrogen phosphate to 1 / 2 parts by weight of ionized water to obtain a mixed liquid I, next, adding such components as vitamin C, polyvinyl alcohol, calcium chloride, borax, glycerinum and mannose to the rest parts by weight of deionized water to obtain a mixed liquid II, and finally, mixing the sea-buckthorn extract, the Chinese atractylode rhizome extract, the mixed liquid I and the mixed liquid II, namely performing a thermal reaction, thereby obtaining the hydrogel dressing. The hydrogel dressing is capable of promoting the healing of a wound, and lasting in antibacterial effect and low in production cost.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, in particular to a hydrogel dressing and a preparation method thereof. Background technique [0002] Wound dressing is a medical material that can temporarily protect wounds, prevent wound contamination, and promote healing. It is an important medical product. Skin trauma may cause various damages, such as increased metabolism, decreased body temperature, excessive loss of water and protein, and disorders of the endocrine and immune systems. Due to the various causes of wounds, different wounds have great differences in size, shape, and amount of exudate, so the wounds have different requirements for dressings. [0003] The main functions of wound dressings are reflected in the following aspects: (1) control wound exudate; (2) avoid or control wound infection; (3) remove or control wound odor; (4) relieve pain; 5) Ensure the patient's comfort as much as possible; (6) Conceal the wound...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61L15/44A61L15/40A61L15/28A61L15/24A61L15/18A61L15/20A61L15/42
Inventor 周朝元刘晓晨苏国宝郭晓亮牛珊珊
Owner 南京竹海生物科技有限公司
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