Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method

A technology of nano-zinc oxide and weaned piglets is applied in the field of anti-diarrhea agents for weaned piglets to achieve narrow and small particle size distribution, solve the problems of agglomeration and stability, and have good dispersion performance.

Inactive Publication Date: 2012-02-01
ZHEJIANG UNIV
View PDF7 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the above-mentioned products have a certain effect on the anti-diarrhea of ​​weaned piglets, they all need to be further improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0029] Nano-ZnO / montmorillonite intercalation composites were prepared according to the method described in the literature (Du Yiting. In-situ synthesis of nano-silver and zinc oxide between montmorillonite layers. Guilin Institute of Technology, 2008.), by weight percentage, The content of zinc oxide in the nanocomposite is 10%.

[0030] Table 1 Dissociation rate of zinc oxide in simulated stomach in vitro (pH value 2.5)

[0031] Ordinary zinc oxide Supported Nano Zinc Oxide ZnO dissociation rate, % 55.2±6.3 9.2±1.2

[0032] It can be seen from Table 1 that the dissociation rate of montmorillonite-loaded nano-ZnO in the simulated stomach in vitro is significantly lower than that of ordinary ZnO.

[0033]A total of 96 (5.7±0.2 kg) 21-day-old “Du × Chang × Da” weaned piglets were randomly divided into 3 groups: (1) control group, fed with basic diet; (2) zinc oxide group, fed with basic diet 2500 mg / kg zinc oxide (calculated as zinc); (3) loaded nano-...

Embodiment 2

[0035] According to the literature (Gong Zhaozhuo, Zheng Shuilin, Lu Fangli, Shen Hongling, Sun Zhiming. Preparation of nano-zinc oxide-calcined kaolin composite materials. China Powder Technology, 2010, 16: 58-60) to prepare kaolin-loaded nano-zinc oxide composite materials, The content of zinc oxide in the nanocomposite is 20% by weight.

[0036] Table 1 Dissociation rate of zinc oxide in simulated stomach in vitro (pH value 2.5)

[0037] Ordinary zinc oxide Supported Nano Zinc Oxide ZnO dissociation rate, % 55.2±6.3 11.6±1.7

[0038] It can be seen from Table 1 that the zinc oxide dissociation rate of kaolin-loaded nano zinc oxide in simulated stomach in vitro is significantly lower than that of ordinary zinc oxide.

[0039] The test results of adding 2500 mg / kg (calculated as zinc) zinc oxide and 300 mg / kg (calculated as zinc) loaded nano-zinc oxide in the diet of weaned piglets showed that 300 mg / kg loaded nano-zinc oxide can reduce the weaning ...

Embodiment 3

[0041] According to the literature (Lin Zhang, Zhang Zhen, Yang Lefu, Ma Zengxin, Lin Jingdong, Liao Daiwei. Research on antibacterial performance of nano-zinc oxide and loaded zeolite. Chemical Research and Application, 2009, 2l: 1309-1313.) method to prepare zeolite-nano-zinc oxide For the composite material, the content of zinc oxide in the nanocomposite material is 30% by weight percentage.

[0042] The results of the determination of zinc oxide dissociation rate (pH 2.5) in simulated stomach in vitro showed that the dissociation rate of zinc oxide in zeolite-nano zinc oxide composite material was 12.5±2.1 in simulated stomach in vitro, which was significantly lower than that of ordinary zinc oxide (55.2±6.3).

[0043] The test results of adding 3000 mg / kg (calculated as zinc) zinc oxide and 500 mg / kg (calculated as zinc) loaded nano-zinc oxide in the diet of weaned piglets showed that 500 mg / kg loaded nano-zinc oxide can reduce the The diarrhea rate of piglets was 82.6%, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses use of supported nano zinc oxide as an anti-diarrhea agent for weaned pigs and a using method. According to the use of the supported nano zinc oxide as the anti-diarrhea agent for the weaned pigs, the supported nano zinc oxide is a composite material for supporting nano zinc oxide by using kaolin or montmorillonite or attapulgite or sepiolite or zeolite as a supporter. The zinc oxide accounts for 10 to 50 weight percent of the composite material for supporting the nano zinc oxide. The using method of the supported nano zinc oxide serving as the anti-diarrhea agent for the weaned pigs comprises that 160 to 800 mg/kg of supported nano zinc oxide based on zinc is added into a weaned pig feed. The supported nano zinc oxide can remarkably reduce the diarrhea rate of the weaned pigs, improve the daily gain, improve the form of the intestinal mucous membrane and protect the intestinal mucous membrane barrier; the fur of the pigs is red and bright; the toxic or side effect of high-zinc daily ration on the pigs is avoided; and the effect of the supported nano zinc oxide exceeds that of high-dose common zinc oxide, the consumption of the zinc oxide is greatly reduced, and zinc excretion and environmental pollution are reduced.

Description

technical field [0001] The invention relates to the application and application method of a loaded nanometer zinc oxide as an antidiarrheal agent for weaned piglets. Specifically, it is a use and method of using kaolin, montmorillonite, attapulgite, sepiolite, zeolite, etc. as a carrier, and a composite material loaded with nanometer zinc oxide as an antidiarrheal agent for weaned piglets. Background technique [0002] Weaning causes stress to piglets, which can easily cause "piglet weaning syndrome", cause diarrhea in piglets, and then affect the growth of piglets. After weaning, piglets change from sucking breast milk to eating solid diets. This stress will damage the immature intestinal mucosal barrier of piglets; at the same time, the disappearance of maternal antibodies will also reduce the resistance of piglets; environmental changes will also Increase the exposure of piglets to pathogenic bacteria, which may cause diarrhea in piglets. The increased permeability of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/12A61K47/02A61K33/30
Inventor 胡彩虹游兆彤李卫芬朱康栾兆双
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap