Knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof

A technology of nanofibers and electrospun nanofibers, applied in knitting, weft knitting, textiles and papermaking, etc., can solve the problems of inability to simulate the mechanical properties of natural tendon with fiber structure, so as to promote tendon repair and normal function recovery, and reduce inflammation Response and enhance the effect of mechanical properties of regenerated tissue

Inactive Publication Date: 2019-10-15
DONGHUA UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a multi-layer structure nanofiber yarn knitted tendon scaffold and its preparation and application, to overcome the defects that the prior art cannot simulate the fiber structure of tendon tissue extracellular matrix and match the mechanical properties of natural tendon, The present invention uses the e

Method used

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  • Knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof
  • Knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof
  • Knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof

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[0051] Example 1

[0052] (1) Preparation of polymer spinning solution: Weigh 1.0g of P(LLA-CL) (75:25) (purchased from Jinan Daigang Biotechnology Co., Ltd.) with a molecular weight of approximately 80,000 and dissolve it in 10mL of hexafluoroisopropanol (Purchased from Shanghai Darui Fine Chemicals Co., Ltd.), mixed with 10% mass concentration of P (LLA-CL) spinning solution.

[0053] (2) Preparation of gelatin spinning solution: Weigh 1.2 g of cowhide gelatin (Ge) (Type A gelatin, purchased from Sigma-Aldrich, USA) and dissolve it in 10 mL of trifluoroethanol (purchased from Shanghai Darui Fine Chemicals Co., Ltd.) , Formulated into a gelatin spinning solution with a mass concentration of 12%.

[0054] (3) Preparation of double-layer nanofiber yarn: the PET yarn is placed in the electrospun nanofiber yarn preparation equipment as the core layer, and the P (LLA-CL) spinning solution in step (1) is sprayed on the opposite side, using rotation The hopper twists the P (LLA-CL) nanof...

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Abstract

The invention relates to a knitted multilayered-structure nanofiber yarn tendon scaffold as well as preparation and application thereof. Yarn is of a multilayered core spun structure. The preparationcomprises steps as follows: core layer yarn penetrates through a hollow rotating funnel to serve as a receiving device, positive and negative high-voltage power sources are applied to double needles on the two sides respectively, electrospun nanofibers are twisted to the core layer yarn, and double-layer continuous nanofiber yarn is prepared; the double-layer nanofiber yarn is taken as a core layer, electrospun natural polymer nanofibers are arranged on the outer layer, and three layers of nanofiber yarn are prepared; finally, the 3D knitted scaffold is prepared from the different layers of nanofiber yarn with a knitting technology and is used for tendon repair. The knitted multilayered-structure nanofiber yarn scaffold has the characteristics that a function of enhancing mechanical properties of regenerated tissue for a long time is realized, biocompatibility is good and repair and normal function recovery of tendon injury are facilitated.

Description

technical field [0001] The invention belongs to the field of support and its preparation and application, and in particular relates to a multi-layer structure nanofiber yarn knitted tendon support and its preparation and application. Background technique [0002] Tendons are tough, regular lines of connective tissue that connect muscles to bones, transfer the force from the muscles to the bones, and allow the joints to maintain stability and movement. As humans live longer, 25% of adults may develop tendon-related problems. Tendon injury is mainly caused by a single severe impact or frequent stretching under the action of low-intensity external force. The tendon cannot be completely regenerated after injury, and the characteristic reaction is fibrous hyperplasia. Current treatments for tendon injuries include surgical sutures, autografts, allografts, xenografts, and permanent tendon prostheses. Tendon grafts clinically used for surgical treatment cannot meet the requiremen...

Claims

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Application Information

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IPC IPC(8): D02G3/04D02G3/36D02G3/44D04B1/16D04B1/22A61F2/08
CPCA61F2/08D02G3/04D02G3/36D02G3/448D04B1/16D04B1/22D10B2211/20D10B2331/04D10B2331/041
Inventor 莫秀梅谢宪瑞吴晶磊王晓宇徐小青陈玉杰沈怿弘
Owner DONGHUA UNIV
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