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Method for detecting illegally-added 42 chemicals in Chinese patent medicines and health care products simultaneously

A detection method and illegal addition technology, applied in the field of food safety and food safety detection, can solve problems such as difficult effective market supervision, incomplete screening, long detection cycle, etc., and achieve simple pre-treatment process, fast detection speed, and selectivity strong effect

Inactive Publication Date: 2015-12-16
ANIMAL AND PLANT & FOOD DETECTION CENTER JIANGSU ENTRY EXIT INSPECTION AND QUARANTINE BUREAU +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] These detection methods only detect a certain type of health products, so there are problems such as incomplete screening, easy to cause missed detection, long detection cycle and high cost.
These problems have brought difficulties to law enforcement, making it difficult for relevant departments to effectively supervise the market

Method used

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  • Method for detecting illegally-added 42 chemicals in Chinese patent medicines and health care products simultaneously
  • Method for detecting illegally-added 42 chemicals in Chinese patent medicines and health care products simultaneously
  • Method for detecting illegally-added 42 chemicals in Chinese patent medicines and health care products simultaneously

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1. Detection of illegally added chemicals in functional drinks

[0028] (1) Sample preparation

[0029] Accurately weigh 2.00g (±0.01g) of a blank beverage sample that does not contain chemicals into a volumetric flask, add about 4ml of methanol aqueous solution (v:v, 1:1), and mix in the mixed solution with a concentration of 50ng / g. Dalafil, Reddenafil, Reddenafil, Homosildenafil, Sildenafil, Pseudovardenafil, Hydroxyhomosildenafil, Aminotadalafil, Thioai Denafil was mixed, and the volume was adjusted to 10ml. After centrifugal filtration, it was passed through a 0.45 μm filter membrane into an injection bottle for determination by high performance liquid chromatography-high resolution liquid chromatography-mass spectrometer.

[0030] (2) The chromatographic separation conditions of the high performance liquid chromatography-high resolution mass spectrometer are shown in Table 1, the analytical column filler used is C18, and the column temperature is 30°C.

...

Embodiment 2

[0039]On the basis of Example 1, further in this example, standard working solutions with mass concentrations of 10, 50, 75, 100.0, and 200.0 ng / mL were prepared, and the chromatographic peak area of ​​the characteristic ion of the target was taken as the ordinate y , Draw the standard working curve with the concentration of the target substance as the abscissa x. All compounds had a good linear relationship in the range of 10-200ng / mL, and the correlation coefficient (r) was greater than 0.99. If the response value of the drug in the sample solution is not within the linear range of the instrument, it should be properly diluted to the corresponding concentration range.

[0040] To determine whether there is any illegally added chemical drug in the sample, the following conditions must be met: the retention time deviation of the target substance in the sample solution and the retention time of the standard solution is within ±2.5%; The deviation of the accurate mass of the se...

Embodiment 3

[0046] Example 3. Detection of illegally added chemical drugs in propolis capsules and functional drinks

[0047] The application of illegally added chemicals in propolis capsules and functional drinks were detected respectively. According to the following methods, the propolis capsules and functional drinks were processed respectively.

[0048] Propolis capsules: Accurately weigh 2.00g (±0.01g) of the contents of the capsules into a volumetric flask, add about 4ml of methanol aqueous solution (v:v, 1:1), vortex to mix and dissolve, dilute to 10ml, and place in an ultrasonic extractor , sonicated for 20 minutes, centrifugally filtered, and passed through a 0.45 μm filter membrane into a sampling bottle for determination by high performance liquid chromatography-high resolution liquid chromatography-mass spectrometer.

[0049] Functional beverages: Accurately weigh 2.00g (±0.01g) of the beverage into a volumetric flask, add about 4ml of methanol aqueous solution (v:v, 1:1), di...

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Abstract

The invention relates to a method for detecting illegally-added 42 chemicals in Chinese patent medicines and health care products simultaneously and belongs to the field of food safety. The detecting method disclosed by the invention is a high performance liquid chromatography-quadrupole / electrostatic field orbitrap high-resolution mass spectrum combined detecting method. According to the established method, the pretreatment process is simple and convenient, the analysis time is short, and the method is accurate, reliable, high in sensitivity and suitable for qualitative confirmation and quantitative detection of the illegally-added 42 chemicals in the Chinese patent medicines and the health care products and can be used for screening illegally-added drugs in the Chinese patent medicines and the health care products. Effective evidence is provided for control of quality of the health care products and fighting of illegal addition behaviors in the industry of health care products.

Description

technical field [0001] The invention relates to a method for simultaneously detecting 42 kinds of chemicals illegally added in Chinese patent medicines and health care products, belonging to the field of food safety, especially the field of food safety detection. Background technique [0002] With the improvement of living conditions and the development of social economy, more and more people begin to pay attention to their own health. Most people think that traditional Chinese medicine and health food have moderate effects and relatively small side effects. Therefore, people are more interested in health food and Chinese medicine. There is also a growing demand for finished medicines. Among them, health foods that relieve physical fatigue (improving yang), assist in lowering blood pressure, assist in lowering blood sugar, and improve sleep function are the best-selling consumer products. [0003] However, the illegal addition of chemicals to Chinese patent medicines and he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 沈崇钰刘芸丁涛吴斌张睿柳菡费晓庆桂茜雯黄志强
Owner ANIMAL AND PLANT & FOOD DETECTION CENTER JIANGSU ENTRY EXIT INSPECTION AND QUARANTINE BUREAU
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