Antimicrobial compositions

An antibacterial composition and technology of the composition, applied in the direction of organic cleaning composition, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve the problems of being expensive and having no biocidal effect

Inactive Publication Date: 2005-10-26
LONZA LTD
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Natural products, while safe, are generally expensive and not biocidal against a broad spectrum of organisms such as Gram-negative and Gram-positive bacteria and fungi
Most natural products are only effective against Gram-positive bacteria at relatively high concentrations and not against Gram-negative bacteria or fungi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antimicrobial compositions
  • Antimicrobial compositions
  • Antimicrobial compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Each of the anionic shampoo samples in Figures 1-3 were tested as described below. Follow the steps below to prepare a standardized mixed bacterial solution. Three agar stabs of Staphylococcus aureus (ATCC #6538), Pseudomonas aeruginosa (ATCC #9027) and Escherichia coli (ATCC #8739) were each incubated at about 35°C for about 24 hours. Each puncture was then washed with 3 mL of 0.85% sterile saline solution. Pool the washes from the three punctures together to form the biota mixture. The absorbance of the organism mixture at 530 nm was adjusted to about 1.00 by adding saline. Calibrate the spectrometer with a saline blank. A standardized mixed bacterial solution was prepared by mixing together 5 mL aliquots of this organism mixture. Then, 0.2 mL of the standardized mixed bacterial solution was inoculated and mixed in 40 g samples of each shampoo. One gram of this mixture was added to a sterile 20 x 150 mm screw cap test tube.

[0096] Add 9 mL of sterile D / E neutr...

Embodiment 2

[0101] Each of the anionic shampoo samples in Figures 4-7 were tested as described below. Follow the steps below to prepare a standardized mixed bacterial solution. Two Candida albicans agar stabs and four Aspergillus niger agar slants were incubated at about 25°C for about 48 hours and 7 days, respectively. Each puncture was then rinsed with 3 mL of 0.85% sterile saline solution, collected and macerated in a tissue grinder. A sufficient amount of 0.85% saline solution was added to each puncture and each inoculum of Candida albicans and Aspergillus niger was visually counted under a microscope with a Neubauer Hemocytometer. Equal volumes of each standardized inoculum of C. albicans and A. niger were mixed together to form a standardized mixed fungal solution.

[0102] A 40 gram sample of each shampoo was inoculated with 0.4 mL of the standardized mixed fungal solution and mixed. One gram of this mixture was added to a sterile 20 x 150 mm screw cap test tube.

[0103] Add 9...

Embodiment 3

[0107] The procedure described in Example 1 was repeated with the preservative formulations listed in Table 1 below. Adjust the shampoo pH to 6.5. The results are also listed in Table 1.

[0108] Preservatives

0 days

cfu / g

7 days

cfu / g

14 days

cfu / g

28 days

cfu / g

0.3% mixture by weight, containing 75% sorbus

Potassium Erythorbate and 25% Sodium Erythorbate

1-3×10 6

＜10

＜10

＜10

0.3% by weight mixture containing 75% Benzene

sodium erythorbate and 25% sodium erythorbate

1-3×10 6

＜10

＜10

＜10

0.45% by weight sodium erythorbate

1-3×10 6

＞3×10 6

＞3×10 6

＞3×10 6

0.45% by weight sodium benzoate

1-3×10 6

1×10 5

7×10 5

＜10

0.45% by weight potassium sorbate

1-3×10 6

1×10 5

6×10 4

not detected

Unpreserved Shampoo

1-3×10 6

＞3×10...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention provides an antimicrobial composition comprising an antimicrobial effective amount (such as a preservative, bactericidal, and/or fungicidal effective amount) of a mixture comprising at least two of: (a) lemon grass oil; (b) cinnamaldehyde, cinnamon oil, cinnamomum cassia, cinnamon extract, cassia leaf oil, 3,4-dihydroxycinnamic acid or salt thereof, or a mixture thereof; (c) sorbic acid, or a salt thereof; (d) erythorbic acid, or a salt thereof; (e) benzoic acid, or a salt thereof; (f) arabinogalactan, galactoarabinan, or a mixture thereof; (g) a hexahydro-iso-alpha-acid, tetrahydro-iso-alpha-acid, or a mixture thereof; (h) Achillea fragrantissima oils, Santolina fragrantissima oils, Forssk oils, Lavender cotton oils; and (i) Glucono Delta Lactone. The present invention also provides a product (preferably a product other than a foodstuff, pharmaceutical, or cosmetic) comprising a preservative effective amount of cinnamaldehyde or a mixture of cinnamaldehyde and one or more alkanol-dialkyl hydantoins.

Description

[0001] This application claims priority to US Provisional Applications 60 / 403,004 and 60 / 403,169, filed August 12, 2002, both of which are hereby incorporated by reference in their entirety. field of invention [0002] The present invention relates to (1) antimicrobial compositions, (2) methods of killing and / or inhibiting the growth of microorganisms, (3) methods of preserving products with antimicrobial compositions, and (4) methods of enhancing antimicrobial compositions. Background of the invention [0003] Natural products, while safe, are generally expensive and not biocidal against a broad spectrum of organisms such as Gram-negative and Gram-positive bacteria and fungi. Most natural products are only effective against Gram-positive bacteria and not Gram-negative bacteria or fungi at relatively high concentrations. [0004] Cinnamaldehyde is a natural product that has been used (1) as a flavoring agent, (2) in preservative systems, and (3) to control insect and spider ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789
CPCY02A50/30
Inventor P·J·卢茨O·伯洛克霍夫S·阿布拉汉
Owner LONZA LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap