The invention relates to a multifunctional leather preparation method. The multifunctional leather preparation method comprises the following steps that 101, blind holes are dilled on a first layer of leather, the density of the holes is 2/cm<2>, and the diameter of the holes is 0.1 cm; 102, the blind holes are filled with deodorants; 103, the two sides of the first layer of leather are pasted with a second layer of leather and a third layer of leather; 104, the three layers of leather are put into a paclitaxel solution to be immersed for 30 min and are dried; 105, the surface of the leather is coated with real stone paint; and 106, the leather is immersed in a supersaturated potassium chloride water solution for 15 min at the temperature of 4 DEG C, is taken out and is put into an autoclave to be processed for 15 min at the temperature of 105 DEG C, drying is conducted, a leather color brightening agent is added, and the leather is processed for 15 min and immersed in an interferon solution for 20 min. According to the multifunctional leather preparation method, the preparation process is simple, and the prepared leather has a good healthcare function.