34 results about "Unmet needs" patented technology

Determining a routing of vehicles for pickup and delivery in a supply chain network, in one aspect, may include generating a plurality of candidate set of routes for vehicles for pickup and delivery to meet demand at multiple target locations. Unsatisfied demand at said multiple target locations resulting from completing pickup and delivery according to the generated plurality of candidate set of routes may be determined. A set of vehicles routes are selected from said plurality of candidate set of routes that minimizes said unsatisfied demand across all said multiple target locations by applying an optimization function.

Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.

Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.

The present invention provides for systems and methods of transmitting and converting a landscape image to a portrait image for use in a virtual reality (VR) and augmented reality (AR) environment at a very high speed with negligible latency thus providing a seamless video feed to enhance the VR or AR environment to meet the demands of VR and AR head mounted displays. The present invention further provides for systems and methods for compositing and communicating video, audio, user data, and commands for VR and AR applications with stationary and moving participants. The present invention overcomes the unmet needs of the art by providing a wireless video processing which includes equipment that has a low power consumption, while providing a reliable and seamless virtual or simulated environment. The present invention further overcomes the unmet need by providing systems and methods to reduce the latency caused by image rotation.

Embodiments of the present disclosure generally relate to devices and methods for sterilizing equipment. More particularly, one or more embodiments described in the present disclosure are directed to portable devices for sterilizing medical equipment in emergency situations. The sterilization devices and method of the present disclosure address an unmet need for sterilizing surgical equipment in a manner that is not only effective and time-efficient, but is also portable and reliable enough to use in emergency medical situations in remote locations where modern sterilization equipment is not available.

The present invention is a collapsible self-propelled chair on wheels that is lightweight in construction and easily collapsed, carried, stored and transported by public or private means. The chair performs the function of a wheelchair while avoiding the appearance of a traditional wheelchair thus avoiding the invalid stigma often associated with wheelchairs. It can be configured as an assistive mobility device to fill the unmet needs of aging healthy adults who wish to retain their independence and social interactions or a medical device to assist those with medical needs. Additional features such as an armrest, a footrest, or a reclining back are easily added during manufacture and because of the chairs uncomplicated design and duplicity of parts, it is very economical to manufacture.

The present invention is a collapsible self-propelled chair on wheels that is lightweight in construction and easily collapsed, carried, stored and transported by public or private means. The chair performs the function of a wheelchair while avoiding the appearance of a traditional wheelchair thus avoiding the invalid stigma often associated with wheelchairs. It can be configured as an assistive mobility device to fill the unmet needs of aging healthy adults who wish to retain their independence and social interactions or a medical device to assist those with medical needs. Additional features such as an armrest, a footrest, or a reclining back are easily added during manufacture and because of the chairs uncomplicated design and duplicity of parts, it is very economical to manufacture.

A product development process directed to elicit previously unknown, unmet needs of consumer group participants using, in a principal aspect of the invention, guided imagery in the idea discovery stage.

Embodiments of the invention provide such an improved system and method. In particular, embodiments relate to systems, methods and apparatuses which use acoustic data in the detection of coronary artery disease. Embodiments can enable fast, non-invasive identification of clinically relevant coronary artery disease, which can ultimately save lives. The non-invasive nature is one example of a multitude of convenient aspects of embodiments that can be used to meet a large, as yet unmet need in a cost-effective and accurate manner. Results can be provided in real-time and with clarity, providing quick and easily understandable indications that can shorten the path to intervention for patients, making embodiments suitable for a wide range of environments, purposes, users and patients.

The present invention discloses a unique kit for providing a combinational therapeutic product comprising a medical device and a pharmaceutical composition to treat mammal diseases. The medical device is to meet these unmet needs of cleansing out these harmful substances, such as viruses, multiple drug resistant bacteria, fungi, pollen, dusts, or excessive mucus. The pharmaceutical composition adds the required functions of anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, to have the added effect of the medical device. The method of using the combinational product is also disclosed. The new product can be used to prevent and treat a variety of diseases, such as common cold, drug resistant influenza, sinusitis, post nasal drip, virus-triggered asthma, or chronic obstructive pulmonary disease. In addition, the new kit and the process of use are safe and cost effective.

The present invention is a collapsible self-propelled chair on wheels that is lightweight in construction and easily collapsed, carried, stored and transported by public or private means. The chair performs the function of a wheelchair while avoiding the appearance of a traditional wheelchair thus avoiding the invalid stigma often associated with wheelchairs. It can be configured as an assistive mobility device to fill the unmet needs of aging healthy adults who wish to retain their independence and social interactions or a medical device to assist those with medical needs. Additional features such as removable armrest, seat belts, a footrest, or a reclining back are easily added during manufacture and because of the chairs uncomplicated design and duplicity of parts, it is very economical to manufacture.

A method for determining the post-launch performance of a product on a market is provided. The method involves storing, in a database, collected data related to at least one key success factor associated with at least the market performance which is related to said product; storing, in a database, collected data related to unmet needs on said market; storing, in a database, collected data related to the propensity of a decision-maker to choose said product; and using a computer to calculate the future market share of said product based on said collected data, thereby determining said post-launch performance on said market. The method allows improved forecasting of the future performance of a product on a market and provides improved understanding, benchmarking, forecasting and strategic decision-making as regards the future sales of the product in question.

A novel renal precursor cell is identified from kidney tissue. The cell is multipotent capable of forming renal epithelial and endothelial tissues. The cell can be amplified in culture and maintains stemness over multiple passages. This cell fulfills a major unmet need as a cell-based source for kidney regeneration or repair. Treatment of kidney diseases and disorders (e.g., glomerularpathies and acute tubular necrosis) may be improved thereby.

The present invention provides a bodyweight-bearing process and device for stair-stepping and climbing exercise, resolving an unmet need in the industry of climbing and stair-based exercise machines. It surpasses all previously patented and commercially available exercise and physical therapy equipment which aim to replicate the act of climbing, by achieving a more complete, correct and natural movement for the user. As indicated by the expanding body of knowledge and evolving recommendations of the exercise science community and health and fitness industries, full-body conditioning and bodyweight-bearing movements, as accomplished by the present invention, are the most effective exercises for weight-loss, strength-training and overall maintenance of health.

A high-frequency copper claded laminate for use in an operational frequency of at least 1 GHz possesses properties of dielectric constant (Dk) less than 3.2, dissipation factor (Df) less than 0.005, high glass transition temperature, high thermal stability and low moisture absorption; the laminate contains a tack-free prepreg constituted by a reinforcement impregnated with an inventive resin mixture at least comprising a high-molecular-weight polybutadiene resin, a low-molecular-weight polybutadiene resin, a modified thermosetting polyphenylene ether resin and an inorganic powder; and particularly the tack-free prepreg can be processed into the copper claded laminates through automated layup processing to satisfy a long-felt but unmet needs in the filed of producing copper claded laminate.

A wireless communication system for delivering ad-hoc data from a plurality of at least device, Di (i=1 . . . N), with each device comprising a communication-module configured for wireless communication with a predetermined environment, and a non-transitory computer readable medium (CRM) configured to control the communication-module [130]; wherein the CRM [110] further comprises a coding-module configured to periodically assign an updated SSID string to be broadcasted by the communication-module; further wherein the SSID is associated with the data such that the wireless communication is implemented by utilizing the SSID string. BACKGROUND OF THE INVENTION An SSID is a unique ID that consists of up to 32 characters and is used for naming wireless networks. When multiple wireless networks overlap in a certain location, SSIDs make sure that data gets sent to the correct destination. Each packet sent over a wireless network includes the SSID, which ensures that the data being sent over the air arrives at the correct location. Without service set identifiers, sending and receiving data in a location with multiple wireless networks would be chaotic and unpredictable to say the least. There is an unmet need for a system or method that frequently changes the SSID of a communicating device to a message for delivering ad-hoc data or information for applications like Many-To-Many devices communication.

The present invention provides a tangle-free pet collar apparatus to be worn around the neck of an animal. The collar apparatus includes an outer wheel and an inner wheel, that when the inner wheel is set within the outer wheel a bearing is formed. The inner wheel and said outer wheel are free to rotate about each other upon forming a bearing. The collar apparatus further includes an elongated length of material having a first end and a second end, at least one inner wheel connection mechanism for attaching a leash, and at least one outer wheel connection mechanism. The first and second end of the elongated length of material, when fastened to the outer wheel, forms a collar for wearing about an animal's neck. This collar apparatus keeps the leash from tangling or knotting in addition to solving additional unmet needs.

The disclosed invention addresses an unmet need of biofluid analysis by utilizing the presence of certain nucleotides, e.g., microDNA, eccDNA, DNA fragments, microRNA, RNA fragments, and peptides, in a sample biofluid, such as eccrine sweat, apocrine sweat, blood, serum, saliva or tears, to perform a number of physiological sensing functions. Specifically, the present disclosure provides: (1) a device and method of determining whether a biofluid sensing device is being worn by a specific individual based on a measurement of nucleotides in a biofluid; (2) a device and method of recognizing at least one physiological disease or condition based on nucleotide concentrations, ratios, or trends in a biofluid.

Described herein are methods for the production of extracellular vesicles comprising culturing a population of producer cells in single-cell suspension, wherein the cells are cultured in chemically-defined culture medium, wherein the culture medium lacks animal-derived serum and animal-derived components; and obtaining from the cell culture an extracellular vesicle preparation comprising extracellular vesicles. In certain embodiments, the methods comprise perfusion culturing methods, including single-cell perfusion culturing methods and batch-refeed culturing methods. The methods described herein are a significant improvement over the state of the art and fulfills an unmet need in the field of extracellular vesicle manufacturing and quality control.

In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies for the effective treatment of a wide range of age-related diseases, including cancer. The present invention also provides methods for preparing compounds of the invention thereto.

Embodiments of the present disclosure generally relate to devices and methods for sterilizing equipment. More particularly, one or more embodiments described in the present disclosure are directed to portable devices for sterilizing medical equipment in emergency situations. The sterilization devices and method of the present disclosure address an unmet need for sterilizing surgical equipment in a manner that is not only effective and time-efficient, but is also portable and reliable enough to use in emergency medical situations in remote locations where modern sterilization equipment is not available.

The invention relates to an apparatus and a method therewith to quantify visual field in infants. The invention provides a novel solution to the unmet need of detection of defects in the visual field in infants and / or babies and providing an apparatus with a software framework to minimize the errors of recording the readings and increasing their precision and analyzing said results automatically using the software embedded in the system. Said apparatus to quantify visual field in infants comprise of a light projection device onto a dome-shaped hemispherical structure with an infra-red camera along with fixation lights, a means for monitoring responses of the subject during testing, a means for recording and analyzing the readings. Said means to detect and record the eye / head movement in the subject during testing comprises said infra red (IR) camera connected to a device wherein software application is embedded.

The invention relates to diagnosis in general and more specifically a system and a method for determining the presence of jaundice in newborn babies, also known as neonatal jaundice.A main objective of the present invention is to provide a simple system and method for determining the presence of jaundice. Particularly since most deaths due to jaundice occur in low-income countries, there is a large unmet need of simple, reliable and affordable technologies able to identify at-risk newborn.The objective is accomplished through receiving a depiction of skin from an RGB sensor, and then using either an optical diffusion model of the skin or Monte Carlo simulations to calculate the bilirubin concentration. A meta model of the optical diffusion model or Monte Carlo simulations can also be used. Colour calibration is also performed by e.g. thin-plate spline interpolation.

In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies for the effective treatment of a wide range of age-related diseases, including cancer. The present invention also provides methods for preparing compounds of the invention thereto.

The present invention provides a mobile wireless communication system, network, and method for managing the use of one or more peripherals with a mobile wireless communication device in connection with an upcoming event. The method includes associating one or more peripherals with one or more users, where the one or more peripherals have an extended capability for use with a mobile wireless communication device, and maintaining a list of the peripheral associations and the respective extended capabilities. Upcoming events and any need for corresponding event supporting capabilities are monitored. Any unmet need for event supporting capabilities is compared with the extended capability of peripherals associated with at least some of the one or more users that will be attending the upcoming event. An indication is provided to at least one of the users that will be attending the upcoming event having an associated peripheral that will address the unmet need for event supporting capabilities of a request to bring the associated peripheral of the at least one of the users to the upcoming event for providing the associated extended capability for use with a mobile wireless communication device.

The present invention provides a mobile wireless communication system, network, and method for managing the use of one or more peripherals with a mobile wireless communication device in connection with an upcoming event. The method includes associating one or more peripherals with one or more users, where the one or more peripherals have an extended capability for use with a mobile wireless communication device, and maintaining a list of the peripheral associations and the respective extended capabilities. Upcoming events and any need for corresponding event supporting capabilities are monitored. Any unmet need for event supporting capabilities is compared with the extended capability of peripherals associated with at least some of the one or more users that will be attending the upcoming event. An indication is provided to at least one of the users that will be attending the upcoming event having an associated peripheral that will address the unmet need for event supporting capabilities of a request to bring the associated peripheral of the at least one of the users to the upcoming event for providing the associated extended capability for use with a mobile wireless communication device.

The invention discloses a resource allocation method of a quality of service guaranteed MIMO-OFDM system, comprising: after the base station of the multi-user MIMO-OFDM system performs singular value decomposition on the channel matrix fed back by users, obtains parallel features on each subband Sub-channels; when the total transmission power of the base station is evenly distributed on all sub-bands and characteristic sub-channels, the base station scheduler allocates multiple sub-bands to users according to the rate of user-supported sub-bands and user priority; The power allocated to each user is redistributed on all the characteristic subchannels corresponding to the allocated subband, and the allocated power and bits are loaded according to the single-user greedy algorithm until the allocated power is loaded. When the rate obtained by the user exceeds its demand, find and deduct the user's surplus subband and the power corresponding to the surplus subband; redistribute the deducted subband and the corresponding power to other unsatisfied users.