78results about How to "Poor absorption" patented technology

Disclosed are improvements in human nutrition involving a unique combination of natural products constituting anti-inflammatory compositions which can reduce cardiovascular disease risks as well as play a positive role in other conditions and diseases for which key indicators, especially selected from the group consisting of C-reactive protein (CRP) levels, cyclooxygenase-2 (COX-2), 5-lypoxygenase (5-LOX) expression and prostaglandin E2 (PGE-2) biosynthesis or any combination of these, are indicators. Therapeutic compositions preferably comprise curcumin, bilberry extract, grape seed extract, green tea extract and apple extract, in effective amounts individually and combined to provide a therapeutically significant reduction in one or more key indicators. Another exemplified therapeutic composition comprises: omega-3 rich refined fish oil, resveratrol, blueberry extract, grape seed extract, green tea extract and gamma and / or delta tocopherol, in effective amounts individually for the above benefits.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

A handpiece and method of use for laser-assisted liposuction for melting, disrupting, and removing cellulite and adipose tissue. Electromagnetic energy is used to selectively melt or disrupt cellulite and adipose tissue and ablate the collagen in the constricting bands of connective tissue that causes the dimpled appearance of cellulite and adipose tissue, while avoiding damage to the surrounding fatty cells.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

A method is described to provide composition for a nutritional supplement for convalescing patients recovering from illness or surgery, those with limited appetite such as the elderly, children or anorexic patients, or those who have impaired ability to digest other sources of protein such as persons having chronic gastritis who have a reduced gastric pepsin digestion. The supplement comprises: (i) a protein source which provides at least about 8% total calories of the composition and which includes at least about 50% by weight whey protein; (ii) a lipid source having an omega 3:6 fatty acid ratio of about 5:1 to about 10:1 and which provides at least about 18% total calories of the composition; (iii) a carbohydrate source; and (iv) a balanced macronutrient profile comprising at least vitamin E and vitamin C. The supplement has reduced capacity to induce satiety. Also disclosed is a method of treatment which comprises administering an effective amount of the composition.

The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.

Ligand-modified poly oxo-hydroxy metal ion materials and their uses are disclosed, in particular for nutritional, medical, cosmetic or biologically related applications for example for the treatment of a deficiency related to a component of the material or for the removal of an endogenous substance capable of binding to the material. The present invention further relates to processes for preparing the materials and optimising their physico-chemical properties and their medical uses.

Compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal, where in the galectin is preferably a galectin-3. The novel compounds are defined by the general formula:

A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng / ml and about 2.0-6.0 ng / ml, respectively.

The invention provides solid compositions comprising (S)-3-(4′-Cyano-biphenyl-4-yl)-2-{[(3S,7S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-1-methyl-2-oxo-6-((S)-1-phenyl-propyl)-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl]-amino}-propionic acid (OC-1) or a salt thereof and methods of making and using those compositions. The invention also provides the monohydrochloride salt of (S)-3-(4′-Cyano-biphenyl-4-yl)-2-{[(3S,7S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-1-methyl-2-oxo-6-((S)-1-phenyl-propyl)-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl]-amino}-propionic acid.

Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal neoplasia; and (b) enterically delivering into the gut of the person an effective amount of an aminoglycoside antibiotic having poor gut absorption, whereby the development of the colorectal neoplasia is reduced as compared with otherwise similar non-treated patients.

Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.

The invention belongs to the technical field of bridge safety and particularly relates to a bridge pier protection device. The bridge pier anti-collision device with a safety air bag comprises a rectangular annular anti-collision energy-dissipation ring surrounding a rectangular bridge pier, wherein the anti-collision energy-dissipation ring surrounds the bridge pier, floats on the water surface and can freely drift. A safety air bag device is installed on the anti-collision energy-dissipation ring and comprises a collision sensor, a controller, an air generator and an air bag arranged on the inner wall of the anti-collision energy-dissipation ring and connected with the air generator, wherein the collision sensor, the controller and the air generator are arranged in the anti-collision energy-dissipation ring. When a ship impacts the outer wall of the anti-collision energy-dissipation ring, the collision sensor transmits a signal to the controller. After the controller triggers the air generator to perform ignition, a large amount of air is rapidly produced to inflate the air bag, and the formed air bag is clamped between a body (energy-dissipation ring) and the bridge pier, absorbs kinetic energy of the body and has the effective buffering effect.

The invention relates to novel AMPK agonist containing compositions that are adapted for localised use in treating inflammation and / or pain due to disease or injury in a human or animal. The novel compositions of the invention are useful in the treatment of a variety of conditions including osteoarthritis (OA), synovitis, tendonitis, desmitis; cystitis, osteitis and laminitis. Routes of administration include intra-articular, direct injection into tissues, instillation, retrograde perfusion and topical. AMPK agonists which can be used include AICAR, metformin, phenformin, A-769662, resveratrol, berberine and polyphenols.

The invention discloses a health product for losing weight and a preparation method thereof. The health product for losing weight is prepared from the following raw materials: coix seeds, seaweed oligosaccharide, tangerine peels, konjak, red beans, wolfberry fruits, wheat grass extract, celery cellulose, Chinese yams, selenium-rich yeast, peanut leaves and lotus leaf extract. The preparation method of the health product comprises the following steps of: decocting the tangerine peels, the wolfberry fruits, the peanut leaves and the lotus leaf extract; filtering to obtain a decocted solution; concentrating the decocted solution to obtain cream; drying the cream and crushing to obtain first mixed powder; drying the coix seeds, the konjak, the red beans and the Chinese yams respectively and grinding into powder; uniformly mixing to obtain second mixed powder; and uniformly mixing the two groups of mixed powder, the wheat grass extract, the seaweed oligosaccharide, the selenium-rich yeast and the celery cellulose to obtain health product powder and sterilizing to obtain the product. The health product has the beneficial effects that the absorption on fat by intestines can be reduced, cholesterol in the intestines and stomach are eliminated and the fat is decomposed and discharged out of a body, so that the good weight losing effect is good.

A sound insulator of the invention includes a sound absorption layer and an air-impermeable resonance layer, which are bonded to each other via an adhesive layer. The sound absorption layer has a thickness in a range of 5 to 50 mm, an area-weight of not greater than 2000 g / m2 and a two-layer structure of a high-density sound absorption layer and a low-density sound absorption layer. The high-density sound absorption layer is bonded to the air-impermeable resonance layer via the adhesive layer and has a density in a range of 0.05 to 0.20 g / cm3 and a thickness in a range of 2 to 30 mm. The low-density sound absorption layer is bonded to the other face of the high-density sound absorption layer via an adhesive layer and has a density in a range of 0.01 to 0.10 g / cm3 and a thickness in a range of 2 to 30 mm.

The present invention relates to the use of flavonoid compounds, particularly quercetin-3-O-β-D-glucuronide and kaempferol-3-O-β-D-glucuronide and their glucosides, for preventing diseases of the heart. Red vine leaf extract has proved a particularly advantageous source of the flavonoid compounds in question.

The invention relates to the field of milk product processing, in particular to a milk powder with functions of maintaining beauty and keeping young and improving immunity of the organism and a preparation method of the milk powder. The milk powder with functions of maintaining beauty and keeping young and improving immunity of the organism includes the following raw materials in percentage by weight: 18-30% of yoyumin powder, 10-15% of medlar powder, 6-10% of soybean meal, 2-3.5% of stachyose powder, 0.13-0.15% of emulsifier and whole milk powder for the rest, wherein the emulsifier is a composition of sucrose fatty acid ester and glycerin monostearate in a ratio of 8:5. The milk powder with functions of maintaining beauty and keeping young and improving immunity of the organism, prepared by combining the yoyumin powder, the medlar powder, the soybean meal and the stachyose powder with the whole milk powder, is adopted; the emulsifier is used and the proportion of the components of the emulsifier is optimized, so that the problems of easy generation of block mass, sendimentation and layering phenomenon in the process of mixing the above four nutrient powders with the milk powder are solved, and the mouth feel of a product and absorption of nutrient components are guaranteed.

An aloe vera based liquid composition comprising at least one antioxidant agent that reduces oxidative stress in the lungs and delivers various antioxidants and nutrients when absorbed upon vaping by the user.

The invention discloses a lucid ganoderma bag cultivation culture medium capable of increasing the content of ganoderan and selenium. The lucid ganoderma bag cultivation culture medium comprises, by weight, 75 parts of wood flour, 20 parts of wheat bran, 2 parts of corn flour, 1 part of lime, 1 part of gypsum and 1 part of sugar. A selenium-enriched nutrient solution is used for adjusting the ratio of the materials to water to be 1: (1.3-1.5). The selenium-enriched nutrient solution is obtained according to a preparation method including: (1), preparing 100 parts of purified water, 1.0 part of L-selenium methionine and 5 parts of corn flour; (2), mixing the raw materials in the step (1), putting the mixture into a high-pressure tank, increasing the pressure to 4kg / cm2 to even the pressure, keeping the pressure for 2-3 minutes, recovering the normal pressure within 1-3 seconds to obtain size, inoculating the size with mature liquid bacillus subtilis cultures by volume percent of 10% at the temperature of 25 DEG C, putting the size into a fermentation tank, injecting sterile air into the fermentation tank, stirring the fermentation tank at the speed of 250r / min, performing fermentation at the temperature of 35-37 DEG C for 4 hours, increasing the temperature to 70 DEG C quickly after fermentation, and keeping 1.0 hour of inactivation to obtain the lucid ganoderma bag cultivation culture medium.

The invention discloses a Ganoderma lucidum karst cultivation method for improving ganoderma lucidum polysaccharides and selenium content. The method comprises the steps of 1, preparation of a culture medium, wherein the culture medium is prepared from, by weight, 75 parts of sawdust, 20 parts of wheat bran, 2 parts of corn flour, 1 part of lime, 1 part of gypsum and 1 part of sugar, and the ratio of the materials to water is adjusted to 1:(1.3-1.5) with a selenium-rich nutrient solution; 2, material mixing, bagging, sterilization and inoculation; 3, spawn running, wherein the inoculated culture medium is placed in a greenhouse for spawn running, at the beginning, the greenhouse temperature is controlled to be 26-28 DEG C, at the 20th day after inoculation, the greenhouse temperature is increased to be 34 DEG C and kept for 20-24 h, and then recovered to be 26-28 DEG C; 4, ganoderma lucidum karst germination, wherein after hyphae grow to be filled with the bag, ganoderma lucidum karst enters into a ganoderma lucidum karst germination period, and the greenhouse temperature is increased to be 34 DEG C at the 5th day, the 10th day, the 15th day and the 20th day in the ganoderma lucidum karst germination period respectively, kept for 20-24 h and then recovered to be 26-28 DEG C.

Methods for treating bacterial infections in the colon, and colonic disorders caused by bacterial infection, using a poorly absorbable form of Rifalazil, are described. Compositions for oral administration, and colonic delivery, of a non- micro-granulated Rifalazil formulation, are also described. Rifalazil is delivered in a form which is poorly absorbed in the gut after oral dosing, and the vast majority of the orally-dosed Rifalazil is not absorbed in the gut. Accordingly, the antibacterial potency in the colonic flora will be enhanced, while absorption and systemic circulation will be reduced, thus reducing potential adverse events.

The invention discloses a lucid-ganoderma cultivation method for increasing the ganoderan and selenium content. The lucid-ganoderma cultivation method includes the steps of 1) medium preparing, wherein a medium is prepared from, by weight, 75 parts of wood flour, 20 parts of wheat bran, 2 parts of corn flour, 1 part of lime, 1 part of gypsum and 1 part of sugar, the ratio of a material to water is adjusted by selenium-rich nutrient liquid to be 1:(1.3-1.5); 2) material stirring, bagging, sterilizing and inoculating; 3) spawn running, wherein after inoculating is carried out, lucid ganoderma is put into a greenhouse and subjected to spawn running, at first, the temperature of the greenhouse is controlled to be 26 DEG C to 28 DEG C, and on the 20th day after inoculating is carried out, the temperature of the greenhouse is increased to be 34 DEG C, the temperature is kept for 20 h to 24 h, and then the temperature of the greenhouse is recovered to be 26 DEG C to 28 DEG C; 4) lucid ganoderma discharging, wherein after hyphas overgrows a bag, the lucid ganoderma enters the lucid ganoderma discharging stage, the temperature of the greenhouse is increased to be 34 DEG C on the 5th day, the 10th day, the 15th day, the 20th day and the 25th day of the lucid ganoderma discharging stage of the lucid ganoderma respectively, the temperature is kept for 20 h to 24 h, and then the temperature of the greenhouse is recovered to be 26 DEG C to 28 DEG C.