Colorectal neoplasia prophylaxis
a technology of colon adenocarcinoma and prophylaxis, which is applied in the field of aminoglycoside antibiotics, can solve the problems of increasing the incidence of colon adenocarcinoma, unable to provide the public with any cure for cancer, inflammatory disease, arthritis, etc., and achieves the reduction of the development of colorectal neoplasia, poor gut absorption, and the effect of reducing the development of colorectal
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[0021] In the following examples, we demonstrate that orally-delivered aminoglycosides reduce development of colorectal neoplasia.
[0022] I. Orally-delivered aminoglycosides reduce development of colon cancer in animal models predisposed to colon neoplasia. Smad3 mutant and APC / MIN mice are fed on a standard laboratory diet, with aminoglycoside antibiotics added to the water. For example, 4 ml neomycin sulfate (BIOSOL, Pharmacia & Upjohn Company) was diluted in 500 ml sterile drinking water to give a final concentration of 1.6 mg / ml neomycin sulfate (1.1 mg / ml neomycin). Metronidazole was diluted in sterile drinking water to a final concentration of 0.5 mg / ml. The same concentrations are used for either combined or separate drug trials.
[0023] Smad3 mutant mice are maintained in 129Sv strain; APC / MIN mice are maintained in C57BL / 6J. Both Smad3 mutant and APC / MIN mice are started on antibiotics at 5 weeks of age (range:4-6 weeks). Mice are monitored and scored for survival and visibl...
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