The invention discloses an aircraft component position and pose adjusting system based on four locators and a method thereof. The position and pose adjusting system comprises four three-coordinate locators, a spherical technical connector, an aircraft component to be adjusted, a laser tracker and a target reflecting sphere, the three-coordinate locator comprises a bottom plate, and an X-direction motion mechanism, a Y-direction motion mechanism, a Z-direction motion mechanism and a displacement sensor which are arranged from the lower part and the upper part in sequence. The position and pose adjusting method comprises the following steps: firstly, a global coordinate system OXYZ is established, and the current position and pose and the target position and pose of the aircraft component to be adjusted are calculated; secondly, the path of the aircraft component to be adjusted from the current position and pose to the target position and pose is planed; thirdly, the tracks of motion mechanisms in all the directions are formed according to the path; and fourthly, the three locators are synergetically moved, and the position adjusting is realized. The method has the following advantages: firstly, the supporting to the aircraft component to be adjusted can be realized; secondly, the automatic adjusting to position and pose of the aircraft component to be adjusted can be realized; and thirdly, the inch adjusting of position and pose of the aircraft component to be adjusted can be realized.