42 results about "Ion binding" patented technology

The present disclosure relates to a brine purification device, its purification method and uses thereof. It is disclosed a brine purification device comprising a housing with an inlet configured to receive untreated brine and an outlet configured to discharge purified brine from a purification chamber; wherein the purification chamber within said housing is configured to have two separated hemispheres; wherein the at least one plate comprises a first engraved serpentine flow channel in a first side configured for the flowing of brine and a second engraved serpentine flow channel in the opposite side of the same plate configured for the flowing of a flowing fluid; wherein the two sides of the at least one plate are separated by an anion-exchange membrane in such a way that the untreated brine combine with counter-ions from the flowing fluid through said anion-exchange membrane; wherein the at least one plate is configured for a fluid velocity of 0.007 to 0.015 m / s considering a thickness of 3 to 6 mm.

The application provides a preparation device and method of nanoscale superfine powder, and relates to the technical field of calcium particle preparation, and comprises a solid-gas mixing cylinder, a positive voltage cylinder, a negative voltage cylinder and a positive-negative ion impact tube; the solid-gas mixing cylinder is provided with a feeding port for inputting animal skeleton coarse particles and oxygen to form a solid-gas mixed gas flow; the solid-gas mixing cylinder is communicated with the positive voltage cylinder and the negative voltage cylinder; the positive voltage cylinder ionizes the oxygen in the solid-gas mixed gas flow into a positive ion state, and the negative voltage cylinder ionizes the oxygen in the solid-gas mixed gas flow into a negative ion state; the outlet of the positive voltage cylinder is communicated with the outlet of the negative voltage cylinder, the solid-gas mixed gas flow with the positive ion state and the solid-gas mixed gas flow with the negative ion state are combined at the outlet and enter the positive-negative ion impact tube, the solid-gas mixed gas flow with the positive ion state and the solid-gas mixed gas flow with the negative ion state in the positive-negative ion impact tube are strongly impacted, and a large amount of energy released when the positive ion and the negative ion combine crushes the animal skeleton coarse particles into superfine powder.

The application provides a mass spectrometry detection device and method for active protein-small molecule interaction, which uses a mass spectrometry sensor to obtain tandem mass spectrometry data of non-covalent complexes of active protein incubated with small molecule compounds at different concentration points; performs non-linear curve fitting on the concentration sequence of the small molecule compounds based on the ion combination rate of the protein binding small molecules at each concentration point, to obtain an apparent dissociation constant of the active protein-small molecule interaction; determines a local conformation change parameter of the active protein induced by small molecule binding and a potential binding domain of the small molecule; and performs fusion evaluation on the binding strength and conformation influence degree of the protein-small molecule interaction based on the apparent dissociation constant, the local conformation change parameter and the potential binding domain, to output a stability grade of the protein-small molecule interaction. Based on the above scheme, non-denatured state mass spectrometry detection of protein-small molecule complexes in a liquid phase environment can be realized.

The invention discloses an engineering bacterium VB27701 capable of adsorbing copper ions as well as a preparation method and application of the engineering bacterium VB27701. The engineering bacterium VB27701 takes Escherichia coli Nissle 1917 as a chassis cell, and comprises a first recombinant covert plasmid and a second recombinant covert plasmid which are used for expressing and displaying the copper ion binding protein CueR on the surface. The engineering bacterium VB27701 constructed by the invention can specifically adsorb copper ions in intestinal tracts, reduces copper circulating in vivo from the source, can be applied to preparation of preparations for adsorbing copper ions in the intestinal tracts of mammals, and can also be applied to preparation of drugs for treating hepatolenticular degeneration.

The preparation method comprises the following steps that S1, a calcium source and an erbium source are dissolved in deionized water, and a solution A containing the calcium ions and the erbium ions is obtained; dissolving a fluorine source in deionized water to obtain a solution B containing fluorine ions; and S2, under the heating condition of 50-85 DEG C, dropwise adding the solution B into the solution A, and carrying out stirring reaction, static aging, washing and drying to obtain the erbium-doped calcium fluoride. According to the method, reaction is carried out in an aqueous solution with the temperature higher than the room temperature, the collision probability of calcium ions, erbium ions and fluorine ions is effectively increased, the doping concentration of the erbium ions in calcium fluoride crystal lattices can be increased to the maximum degree in the process that calcium and fluorine ions are combined and react to generate calcium fluoride, and pure-phase calcium fluoride is generated. And the high-concentration erbium-ion-doped erbium-doped calcium fluoride synthesized by the method is simple in process, short in preparation period and beneficial to industrial mass production.

The invention relates to the technical field of fine chemical engineering, in particular to a method for green production of D-tartaric acid by a double-compartment bipolar membrane process, which comprises the following steps: preparing a raw material sodium tartrate solution generated by hydrolysis of a sodium epoxysuccinate solution through a strain into a raw material solution with the mass concentration of 7-8.5%, and carrying out electrodialysis on the raw material solution through a double-compartment bipolar membrane electrodialysis device to obtain D-tartaric acid. Directional ion migration is realized under the action of direct current; sodium ions enter an alkali side through a positive membrane and are combined with hydroxyl ions generated by dissociation of a bipolar membrane to generate a sodium hydroxide solution with the mass concentration of 3-4%; hydrogen ions enter an acid side through the bipolar membrane and are combined with tartrate ions to generate a D-tartaric acid solution, and a D-tartaric acid finished product is obtained through subsequent concentration and drying; through the mode, one-step conversion from sodium tartrate to D-tartaric acid is realized, the cost is reduced, and the yield is improved.

A solid electrolyte composition of the present disclosure includes: a solid electrolyte material having ion-binding properties; and an organic solvent. The organic solvent includes: a halogen-group-containing compound; and at least one selected from the group consisting of an ether-group-containing compound and a hydrocarbon.

The invention discloses a regeneration method of silicon oxide polishing waste liquid and application thereof. The regeneration method comprises the following steps: S1, collecting crystallized or agglomerated silicon oxide polishing waste liquid; s2, adding a hydrofluoric acid aqueous solution into the waste liquid, uniformly mixing for reaction, eroding bonding points on the surfaces of the agglomerated silicon oxide particles by utilizing hydrofluoric acid, converting part of silicon oxide into movable fluosilicate ions, and combining the fluosilicate ions with metal cations in the waste liquid to generate fluosilicate precipitates; s3, performing primary filtration on the mixed solution treated in the step S2 through a first filter medium to remove particles with the particle size greater than a first threshold value so as to obtain a primary filtrate; s4, the primary filtrate is subjected to secondary filtration through a second filter medium, particles with the particle size larger than a second threshold value are removed, fine filtrate is obtained, and the pore diameter of the second filter medium is smaller than that of the first filter medium; and S5, collecting the fine filtrate as a regenerated silicon oxide polishing solution. The invention aims to reduce the chemical mechanical polishing processing cost of the silicon carbide substrate.

The invention belongs to the technical field of surface treatment, and particularly relates to a cyanide-free lead-free cupronickel tin electroplating process which comprises the following steps: adding methionine copper, sodium stannate, potassium hydroxide, zinc oxide, potassium carbonate, conducting salt, a brightener, sodium phosphite, 3-aminobenzoic acid ethyl ester methyl sulfonate and a wetting agent to form a plating solution; starting mechanical stirring, heating to a required temperature, putting the workpiece into the plating solution, electroplating, and controlling the current density, the metal ion concentration of the plating solution and the temperature to be within a preset range. According to the copper methionine serving as a copper source, copper is coordinated and combined with amino and carboxyl of methionine to form stable inner complex salt, and the advantage of remarkable hydrolysis resistance is achieved. And multiple coordination groups of methionine anions are chelated with Cu < 2 + >, so that free Cu < 2 + > is stabilized, and refining of coating crystallization is assisted. Sodium phosphite focuses on binding with stannate ions to reduce the reduction potential of tin, and ethyl 3-aminobenzoate methyl sulfonate is preferentially chelated with Cu < 2 + > to improve the reduction potential of copper, so that the problem of large potential difference between copper and tin is solved.

The high-temperature anti-corrosion and anti-scaling gradient coating comprises a base layer, an adhesion layer is arranged at the top of the base layer, a middle layer is arranged at the top of the adhesion layer, a first anti-incrustation layer and a second anti-incrustation layer are arranged at the top of the middle layer, the first anti-incrustation layer comprises an adhesion layer, and the second anti-incrustation layer comprises a second anti-incrustation layer. The first anti-incrustation layer comprises a plurality of adhesion layers, first IPSE alloy particles are arranged in the adhesion layers, the second anti-incrustation layer comprises a plurality of strip-shaped adhesion layers, and second IPSE alloy particles are arranged in the strip-shaped adhesion layers. According to the high-temperature anti-corrosion and anti-scaling gradient coating for the incinerator, the first anti-scaling layer and the second anti-scaling layer are coated and polished, IPSE alloy particles in the first anti-scaling layer and the second anti-scaling layer are exposed outside, the first IPSE alloy particles and the second IPSE alloy particles release free electrons after making contact with water, the free electrons are combined with calcium and magnesium cations forming scales in the water, and therefore the scale forming effect is improved. The combination of calcium and magnesium with acid radical ions is prevented, so that the scale inhibition effect is achieved.

The invention relates to the technical field of water treatment, in particular to an electrode pair for water softening and an application method thereof.The electrode pair comprises a positive electrode and a negative electrode, and a water passing channel is formed between the positive electrode and the negative electrode; the positive electrode comprises a current collector as well as a supporting middle layer and a resin layer which are sequentially attached to the current collector, and the negative electrode comprises a current collector as well as a catalyst layer, a supporting middle layer and a resin layer which are sequentially attached to the current collector; the resin layer of the positive electrode is an OH-type anion exchange resin layer, and the resin layer of the negative electrode is an H + type cation exchange resin layer; the support middle layer comprises a binder and conductive powder with the particle size of 100-800 meshes; the catalyst layer includes a noble metal catalyst. The catalyst layer is arranged in the negative electrode, the reverse electrode is the positive electrode during regeneration, water is subjected to in-situ electrolysis under the action of an electric field to generate regenerated ions, and resin recovery is achieved together with the electrolysis action of the negative electrode during regeneration; and meanwhile, the supporting middle layer is matched, so that the adhesion stability of the resin layer is improved.

The invention provides a carbazole-thiazole Schiff base fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescent probes. The preparation method disclosed by the invention comprises the following steps: mixing a benzothiazole-2-formaldehyde solution and a 3-amino-9-ethyl carbazole solution, and then carrying out a Schiff base condensation reaction, so as to obtain the carbazole-thiazole Schiff base fluorescent probe. The preparation method disclosed by the invention is simple, mild in reaction condition, high in yield and low in cost; the fluorescent probe can identify and detect mercury ions, ferric ions, aluminum ions and chromium ions with high selectivity and high sensitivity through fluorescence and color dual signals, the detection limit is as low as nanomole level, and the fluorescent probe has high sensitivity. After being combined with different target ions, the probe respectively shows obvious color change and fluorescence enhancement under sunlight and ultraviolet light, can realize quick distinguishing by naked eyes, and has wide application prospects in the fields of environmental monitoring, biological imaging, food safety detection and the like.

The application discloses a flexible temperature sensor based on a bionic multi-cell mixed ion pump and a preparation method thereof, and relates to the technical field of flexible electronic sensing. The application adopts thermoplastic polyurethane as a flexible substrate, introduces ionic liquid and nano zinc oxide to construct a bionic multi-cell mixed ion pump structure, and proposes a sensing mechanism of heat-induced reversible hydrogen bond rupture to release free ions. Through the formation of a hydrogen bond network between the surface hydroxyl groups of nano ZnO and the anions of ionic liquid, ions are accurately limited, and ion-electron dual signal amplification is realized in combination with the quantum size effect. The resistance temperature coefficient of the sensor in the high-temperature zone can reach 47.9% / DEG C, the temperature resolution is 0.1 DEG C, the response time is 55 ms, the recovery time is 62 ms, the sensor has excellent zero drift cycle stability and excellent mechanical anti-deformation interference capacity, the tensile strength breaks through 30 MPa, and the elongation at break is close to 400%.

The present invention provides a carrier platform functionalized with a chelating agent. The carrier platform has a Formula I as follows: ITP- Pu According to Formula I, ITP represents an integrin-targeting peptide that comprises cRGD, linear RGD or iRGD, MBD represents a metal-ion binding domain comprising a bifunctional chelating agent and Pu is a polymeric unit. The present invention provides a novel radiotheranostic platform suitable for use as diagnostic or imaging agents or therapeutic agent.

The invention discloses an atomic potential well functional device, and relates to the field of micro-nano particle control. The device adopts a two-dimensional film including but not limited to crystal ceramic, amorphous glass or a rigid structure, a natural potential well is formed by valence band gaps, functional atoms or ions are embedded and stably restrained, and control over the atoms or ions is achieved in combination with an electric field, a magnetic field or a light field. And the method can be applied to scenes such as data operation, energy storage, data storage, precision sensing, micro-nano driving, energy capture, imaging display and the like. The device is simple in structure and stable in work, solves the problem that an existing scheme is insufficient in precision and sensitivity, and is wide in application prospect.

A galvanic lead-free oxygen sensor comprises a barrier to the passage of anode metal ions between the anode and the sensing cathode. This reduces the deposition of anode metal compounds on the sensing cathode, extending sensor lifetime. The barrier may comprise an ion-exchange membrane. The barrier may comprise an anode metal ion binding agent, for example a cellulosic material. The anode may comprise copper.

The invention discloses a calcium ion binding protein marker combination for evaluating individual radiosensitivity and application of the calcium ion binding protein marker combination, and belongs to the technical field of biotechnology and nuclear radiation protection. Aiming at the technical problems that a genomics detection method and a functional experiment method for evaluating individual radiosensitivity have obvious limitation and the like at present, the invention is based on a C57BL / 6J mouse half lethal dose radiation experiment for the first time; a radiosensitivity prediction model based on the serum calcium ion binding protein combination (Ihh, NUCB1 and PROS1) is screened and established through a high-throughput mass spectrometry technology, and the clinical application value of the serum calcium ion binding protein combination (Ihh, NUCB1 and PROS1) as the radiosensitivity prediction marker is proved for the first time. A novel molecular marker is provided for professional radiation protection monitoring and formulation of a precise tumor radiotherapy scheme.

The invention discloses an anti-static spinning yarn and a preparation method thereof, and relates to the technical field of textile materials. When the anti-static spinning yarn is prepared, firstly, itaconic anhydride and tetrahydrofuran are subjected to ring opening alternate polymerization, then bromination and N, N-dimethylthiophene-2-methylamine quaternization modification are sequentially carried out, and quaternized polyester is prepared; carrying out melt spinning on quaternized polyester to form fibers, and carrying out wet stretching to obtain matrix fibers; then 3, 4-ethylenedioxythiophene is polymerized on the surface of the fiber to generate a polymer conducting layer, the polymer conducting layer is twisted into yarn, ion binding is conducted through anion phytic acid solution treatment, and finally the anti-static spinning yarn is obtained through sodium bicarbonate solution neutralization and water washing. The anti-static spinning yarn prepared by the method has excellent anti-static property, antibacterial property and flame retardant property.

The invention relates to the technical field of energy storage materials, in particular to an aqueous battery electrode material based on a naphthalimide and perylene diimide hydrogen bond organic framework material as well as a preparation method and application of the aqueous battery electrode material. The material has excellent stability and remarkable current-carrying ion transmission performance, and the unique carbonyl structure of the material realizes reversible current-carrying ion combination and release processes through an enol conversion mechanism, so that efficient charge storage capacity is realized. Under the conditions of 0.5 M (NH4) 2SO4 electrolyte and the current density of 0.5 A / g, the water-based battery shows the reversible specific capacity as high as 205mAh / g. The battery still keeps the specific capacity of 78.6 mAh / g after 26000 times of charge-discharge cycles in 0.5 M (NH4) 2SO4 electrolyte and under the high current density of 10A / g, and shows excellent cycle stability. The preparation process is simple, shows good application prospects, and provides an innovative solution for the field of energy storage.

The present invention relates to an ionic compound, a pharmaceutical composition for treating cancer comprising the ionic compound, and method for preparing the ionic compound and the pharmaceutical composition. More specifically, it relates to a pharmaceutical composition for treating cancer: which comprises an ionic compound in which two different compounds, each different from the other, selected from ascorbic acid, dichloroacetic acid and lactate are combined with one metal ion; has better therapeutic effect by overlapping and complex disturbances of cancer cell metabolism because different compounds are simultaneously uptake into cancer cells and each acts through different mechanisms on cancer cells, compared to the conventional anticancer drugs focusing on one specific mutation or cancer cell growth signal; and can more effectively inhibit the proliferation, invasion and metastasis of cancer cells because it is less susceptible to drug.

A medical device may include a medical device body and / or a coating on the medical device body. The medical device body and / or the coating may be formed from a polyurethane-based resin, which may be a reaction product of ingredients including: a diisocyanate; a chain extender; a polyglycol; and a biomimetic functional modifier. The ingredients of the reaction product may further include an additional ionically-charged modifier and / or a low-surface energy modifier. The biomimetic functional modifier may aid in prevention of thrombus formation, resistance to biofilm colonization, and inhibition of adverse tissue inflammatory response to medical implants. In addition, an ionic active agent may be ionically bound to the biomimetic functional modifier and the additional ionically-charged modifier for active and controlled release. The biomimetic functional modifier may include a phosphorylcholine functional group. The biomimetic functional modifier may be glycerophosphorylcholine. The medical device body may include a catheter tube body.

The invention relates to a method for separating F1-Cu ion neutral active peptide from sheep brain total white protein zymolyte and application of the F1-Cu ion neutral active peptide. The method comprises the following steps: removing surface impurities and fresh blood from fresh sheep brain, performing low-temperature vacuum freeze drying, crushing and sieving to obtain sheep brain powder; degreasing with petroleum ether to obtain sheep brain degreased powder; sequentially carrying out distilled water extraction, centrifugation and freeze drying to obtain a sheep brain albumin crude extract, carrying out enzymolysis with trypsin, and carrying out freeze drying to obtain a sheep brain total albumin trypsin hydrolysate; cM-65OM and DEAE-650M cation and anion exchange resins are used for separation to obtain a neutral part, and then an HW-40F gel column is used for separation to prepare a neutral peptide F1 part combined with Cu ions, wherein the molecular weight of the neutral peptide F1 part is 4KDa. The method is simple in production process, environment-friendly, safe, low in cost, wide in raw material source, easy to obtain, low in price and safe. The obtained polypeptide component not only retains the biological activity of original substances in the sheep brain, but also turns waste into wealth and resources, makes full use of Xinjiang animal husbandry characteristic resources, and realizes high value-added utilization of animal husbandry resources.

The present invention relates to a method for manufacturing lithium hydroxide. Particularly, according to an embodiment of the present invention, a method for manufacturing lithium hydroxide may be provided, the method comprising: a solution preparation step in which a lithium hydroxide solution containing impurities and lithium ions is prepared; a bonding acidic solution passage step in which a bonding acidic solution is passed through a chelating resin so that hydrogen ions are bonded to the chelating resin; a distilled water passage step in which, to remove the acidic solution remaining in the chelating resin, distilled water is passed through the chelating resin; a lithium hydroxide passage step in which the lithium hydroxide solution is passed through the chelating resin so that ions included in the impurities are bonded to the chelating resin; and a separating acidic solution passage step in which a separating acidic solution is passed through the chelating resin to which the impurities are bonded, so that the impurities bonded to the chelating resin are separated from the chelating resin.

The invention relates to a method for stabilising limescale precipitation from drinking or service water in a drinking or service water installation, wherein the drinking or service water comprises dissolved Ca2+ ions and HCO3 - ions, wherein the method comprises the targeted catalytic deprotonation of HCO3 - ions and the continuous formation of CaCO 3 0 - ion pairs in the drinking or service water by contacting the drinking or service water with a polymeric granulate having functional groups, wherein the functional groups of the polymeric granulate comprise carboxylate groups which form cation-binding sites, wherein between 0.01% and 10%, preferably 0.5% to 5%, of the cation-binding sites formed by the carboxylate groups are occupied by at least one di- or trivalent metal cation different from Ca2+, less than 1.5% of the cation-binding sites are occupied by H+ ions, and wherein the remaining cation-binding sites are occupied by Ca2+ ions, with the proviso that the at least one di- or trivalent metal cation different from Ca2+ binds more strongly to the cation-binding sites than Ca2+.

A galvanic lead-free oxygen sensor comprises a metal ion binding agent in contact with the electrolyte to bind ions of the one or more anode metals and thereby restrict the deposition of anode metal compounds on the sensing cathode, extending sensor lifetime. The anode comprises at least copper and the metal ion binding agent may comprise a cellulosic material.

The present disclosure generally relates to devices and methods for extracting ions, including lithium ions. For example, certain aspects generally relate to electrochemical ion exchange techniques in which the ion exchange is electrically driven. In some embodiments, a fluid rich in target ions (e.g., a feed solution) may be present in a compartment housing a target ion selective electrode, and target ions from the fluid may be incorporated into the electrode, for example by applying a suitable current to drive ion exchange. At a second time, the target ions may be removed from the electrode, e.g., into a target ion lean fluid (e.g., recovery solution), e.g., by applying a suitable current to drive ion exchange. In addition, certain embodiments generally relate to stacks of such compartments.

This invention discloses a charge-reversible covalent organic framework (COF) ion separation membrane, its preparation method, and its applications. The membrane uses an AAO rigid membrane as a substrate and is prepared by in-situ growth of a COF active layer via interfacial polymerization using imidazolium salt-functionalized amine monomers and 2,4-dihydroxy-1,3,5-pyromellitic methyl aldehyde monomers. By controlling the alkyl chain length of the monomers, the microenvironment and ion binding state of the membrane pores are altered, achieving directional control of surface positive and negative charges, thus enabling the preparation of anion- or cation-selective membrane materials. This invention relies on molecular side-chain engineering to endow the membrane material with a dual separation mechanism of pore size sieving and electrostatic interaction. The resulting membrane exhibits high flux, excellent selectivity, and strong stability, showing broad application prospects in water treatment, resource recovery, and other fields, and providing a new path for the development of high-performance ion separation membranes.

The present invention relates to a medical device resistant to Candida albicans and antimicrobial activity comprising a medical device surface having a copolymer coating of an antifungal moiety and an ion binding moiety. The copolymer coating is prepared by reacting an antifungal monomer selected from the group consisting of tricyclodecane dimethanol diacrylate, 4-tert-butylcyclohexyl acrylate, neopentyl glycol diacrylate, trimethylcyclohexyl methacrylate, isobornyl acrylate, and mixtures thereof, and an antifungal monomer selected from the group consisting of acrylic acid, acrylic acid, acrylic acid, and mixtures thereof. Ionic binding monomers of methyl acrylate and mixtures thereof are copolymerized. The coating may be loaded with an elutable antimicrobial substance bound to an ion binding moiety. The antimicrobial substance may be a cationic type, such as a cationic dye, such as ethyl violet chloride, a cationic drug, such as chlorhexidine diacetate, a cationic peptide, such as a cecropin, a clawed toad antibacterial peptide, a porcine antibacterial peptide, and a bovine antibacterial peptide, or ionic silver. The medical device may be a catheter having a luminal inner surface and a luminal outer surface, and a copolymer coating disposed on the luminal inner surface and the luminal outer surface.

The invention discloses a protein binding metal ion quantitative analysis method based on prokaryotic expression, relates to a protein and metal ion binding analysis method, and aims to solve the problems that the current protein binding metal ion analysis cost is high, the process is tedious, and metal ions cannot be quantitatively analyzed by most analysis methods. The method comprises the steps of target protein prokaryotic expression, purification and metal ion binding quantitative analysis. The method utilizes a label purification system, indirectly quantifies protein binding metal ions by detecting the content of metal ions in supernatant, and has the advantages of simplicity and convenience in operation, low cost, high sensitivity, strong universality and the like. The method is suitable for quantitative analysis of various metal ions and protein types, and provides an effective tool for protein function research and application. The method is applied to the field of biology.

This application belongs to the field of photodetector technology, and relates to a method for preparing a metal-doped A2BX5 crystal, a thin film thereof, and a photodetector. The method for preparing the metal-doped A2BX5 crystal includes providing a first mixed solution comprising AX, BX2, CX2, and a first solvent; subjecting the first mixed solution to a first heat treatment to obtain a second mixed solution; adding a metal chelating agent to the second mixed solution to obtain a third mixed solution; adding a second solvent to the third mixed solution and performing a second heat treatment to obtain a metal-doped A2BX5 crystal, wherein C is doped in the A2BX5 crystal. The metal chelating agent can bind with B ions in the third mixed solution to form a dynamic supramolecular coordination structure, thereby limiting the nucleation rate of B ions and improving the stability of the metal-doped A2BX5 crystal.