160 results about "Ion binding" patented technology

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and / or the use of hyperkalemia causing drugs.

Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.

A structure and method for chemical sensing utilizing microassays. Microcavities or micropores are combined with assay techniques to provide a very fast and very sensitive means of detecting chemical compounds. Assay techniques are modified to include a metal ion binding carrier species especially suitable for use in conjunction with the electrochemical detection. This allows assays to be combined with electrochemical analysis, thus allowing the high speed ease and hypersensitivity available in the invention disclosed herein.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and / or the use of hyperkalemia causing drugs.

Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.

The invention discloses an annular tubular electrode ion trap used for ion storing and analyzing device, correlating to technology of ion storage and ion mass analysis, especially relates to ion storage and an analysis instrument for analyzing and detecting based on mass-to-charge ratio characteristics of the ion. The annular tubular electrode ion trap has an ion lead-in hole and an ion lead-out hole, two or more annular tubular electrodes of different diameters are assembled together coaxially to compose a set of coaxial annular tubular electrodes, an annular space is formed between two adjacent rings, two plane electrodes are vertical to an axis and are respectively provided on two ends of the annular tubular electrode, boundary electrodes of the ion trap are composed of outer annular tubular electrodes and plane electrodes on two ends, an ion binding area is formed between the adjacent annular tubular electrodes, ions leaded in the area are to be captured, stored or discharged selectively.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.

Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and / or the use of hyperkalemia causing drugs.

The invention relates to a modified chitosan metal composition wood preservative and a preparation method, which is characterized in that,16 to 30 portions of bactericidal metal salt, 15 to 25 portions of chitosan, 6 to 18 portions of perboric acid and salts thereof and 250 to 300 portions of deionized water are mixed at 30 DEG C to 60 DEG C for reaction for 2 to 4 hours, wherein, the dried solid matter is white or green or grey powdery modified chitosan metal composition; then wood preservative aqueous solution is prepared by 0.5 to 5 portions of the metal composition, 0.5 to 2 portions of acid and 100 portions of water. The modified chitosan metal composition wood preservative prepared by the method has the advantages of high metal ion binding rate, broad-spectrum and high-efficient antiseptic effect and low viscosity; by using the preservative, the internal part of wood can be entered, and antisepsis, rot resistance and insect control treatment can be carried out to wood, bamboo and other plant fiber materials by soaking, brushing, spraying, pressure impregnating, etc.

The invention discloses a method for detecting heavy metal and a DNAzyme monomolecular connection device based on a graphene electrode special for same. A manufacturing method for the DNAzyme monomolecular connection device comprises the following steps of: 1) constructing a graphene transistor device array; 2) cutting a nanometer gap of 1-10nm in a graphene molecular device; and 3) connecting a designed DNAzyme sequence into the nanometer gap to obtain the DNAzyme monomolecular connection device. An electrical signal detection with heavy metal ion binding and identification is carried out byutilizing the manufactured DNAzyme monomolecular connection device, meanwhile, the interference factors are excluded; the heavy metal ions are tested in sensitivity and the like on the connection device; and the measurement conditions are determined according to the test results in the above steps, and the heavy metal ions are detected on the connection device. According to the invention, the high-sensitivity detection of the heavy metal can be realized through the electricity signal by utilizing the functionalized graphene electrode molecular device. The method is of great significance in detecting a trace amount of the heavy metal in the environment.

Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.

The invention relates to a browning conditioning fluid containing sulfydryl compound. The browning conditioning fluid is the solution which is used for improving the bonding force between an inner-layer copper surface and a prepreg sheet and also can improve the copper loading amount of the browning conditioning fluid in the production and manufacture technology of the multilayer board of a printed circuit board (PCB). The browning conditioning fluid comprises 90-120g / L of sulfuric acid, 10-20g / L of hydrogen peroxide, 10-20g / L of corrosion inhibitor, 20-50mg / L of halide ion, 1.0-4.0g / L of bonding force accelerator and the balance of water which is added until the solution is 1L, wherein the bonding force accelerator is selected from a sulfydryl-substituted nitrogen-containing heterocycle compound. The copper carrying amount of the browning liquid can reach 50g / L and can be guaranteed to be 1-50g / L. The copper surface is browned to obtain an even and rough brown surface, and the copper surface is kept to have stable and favorable bonding force with the prepreg sheet and excellent heat resistance.

The invention discloses an oxygen sensitive variable ink. The oxygen sensitive variable ink comprises the following components: an oxygen sensitive reactive dye, a reducing agent, a binder, a hydrophobic agent and an organic solvent. By adopting the binder of the variable ink, the film formation viscosity of the ink is increased; an ion binding is generated by the hydrophobic agent and the oxygen sensitive reactive dye, so that the oxygen sensitive reactive dye has a hydrophobic function; besides, the reducing agent of the variable ink can be substituted by a photocatalyst material and an electron donor material, and the variable ink is an UV activated variable ink; after being radiated by the UV light with proper wavelength, the oxygen sensitive reactive dye is re-activated by a photo electron generated by the photocatalyst material so that the oxygen sensitive reactive dye returns to a reducing state, and therefore, whether an oxidizing reaction is generated can be judged through the color change of the oxygen sensitive reactive dye in reducing state.

A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

The invention discloses a detecting method for divalent mercury ions. The principle for detecting mercury ions by using the method is as follows: a single-chain DNA (Deoxyribose Nucleic Acid) molecule B modified by fluorescein contains a sequence which is complementary with a sequence of a DNA catching needle (a single-chain DNA molecule A) fixed on the surface of a probe, and also contains a T-T base pair mismatch structure which can be combined with the divalent mercury ions. During detection, the single-chain DNA molecule B modified by the fluorescein and the mercury ions are simultaneously input to the surface of an optical fiber sensor probe for evanescent waves, and the divalent mercury ions are combined with the single-chain DNA molecule B modified by the fluorescein by the DNA catching needle in a competition way. The more the concentration of the divalent mercury ions is, the fewer the single-chain DNA molecule B modified by the fluorescein and combined with the DNA catching needle on the optical fiber sensor probe for evanescent waves is, so that a fluorescence intensity signal detected by an optical detecting platform for evanescent waves is weaker. An effective means is provided for the rapid on-site and real-time detection of heavy metal mercury ions in the fields of foods, medicines and environments.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and / or the use of hyperkalemia causing drugs.

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and / or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.

A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween.In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

The invention provides a synergistic composition useful as a nitrification inhibiting additive for ammonium producing fertilizers which comprises:(a) benzotriazole in the range of 2.5 to 50% (by wt % of the ammonium fertilizer),(b) metal chelating agent (cooper / nickel in the range from about 1 to 50% (by wt % of the ammonium) and ion binding compound and precursors and fertilizer.

Ion binding compounds and compositions may include compounds, polymers and compositions that include amine moieties. Ion binding polymers may be crosslinked amine polymers and may be used to remove ions, such as phosphate ions, from the gastrointestinal tract of animals, such as humans. Such compounds, polymers and compositions may be used therapeutically to treat a variety of medical conditions, such as hyperphosphatemia.