32results about "Miniaturised spectrometers" patented technology

The invention relates to the technical field of liquid phase mass spectrometers, in particular to a small liquid phase mass spectrometer based on high-precision voltage measurement, which comprises a box body, a box shell is mounted at the top end of the box body through bolts, a first-stage cavity, a second-stage cavity and a placement area are arranged in the box shell, and the first-stage cavity, the second-stage cavity and the placement area are distributed in an up-and-down structure; an ion funnel is arranged in the first-stage cavity, and a taper hole plate is mounted at the top of the inner wall of the second-stage cavity through a bolt; the linear ion trap is a double-potential-well plane, collection of entering ions and controllable cooling and throwing of confined ions can be achieved respectively, and compared with a single-potential-well plane ion trap, the linear ion trap is more sufficient in ion collection and focusing and higher in ion concentration efficiency. Meanwhile, the work cycle, the ion flux and the thrown ions of the double-potential-well plane ion trap all meet the work requirements of the multi-reflection time-of-flight mass analyzer, the double-potential-well plane ion trap can be coupled with the multi-reflection time-of-flight mass analyzer, introduced ions with high flux and concentrated states are provided for the multi-reflection time-of-flight mass analyzer, and the detection accuracy and precision of the liquid phase mass spectrometer are greatly improved.

An ion trap chip and a system are disclosed, and are applicable to the field of quantum computing. The ion trap chip includes: a plurality of first ion traps (10), each configured to store an operation ion, where two adjacent first ion traps (10) form one ion trap group (30); and a plurality of second ion traps (20), where the second ion trap (20) corresponds to one ion trap group (30), and the second ion trap (20) is configured to perform quantum operations of operation ions (101) stored in the corresponding ion trap group (30). The second ion trap (20) is located between two first ion traps (10) in the corresponding ion trap group (30). The operation ions (101) stored in the first ion traps (10) in the ion trap group (30) are transported to the corresponding second ion trap (20) along a straight line. In the ion trap chip, an ion storage area and a quantum operation area are separated, and the ion storage area and the corresponding quantum operation area are located in a same straight line, so that ion transport does not require a turning. This greatly improves quantum computing efficiency.

The polyatomic object crystal is transported from a first leg to a second leg of an atomic object confinement device through a corresponding junction. A voltage source in electrical communication with electrodes of the device is controlled to confine the crystal within the first leg. The voltage source is controlled to cause transport of the crystal along the first leg approaching the junction and then cause a time-dependent potential to be generated at the junction that is configured to cause the crystal to traverse a transport path through the junction from the first leg to the second leg via a dynamic potential well that defines a particular variable axial frequency. The transport path is determined by combining a constant full confinement path for a representative atomic object of the crystal with a path of a high frequency minimum for a representative atomic object using a particular variable path ratio.

A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and / or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

Provided is a mass spectrometer capable of ensuring a work space for maintenance or the like of a turbomolecular pump as compared with one in the related art. A mass spectrometer 10, 10A, 10B includes: an ion source 30; a vacuum chamber 40 into which a sample ion ionized by the ion source 30 is introduced; and a turbomolecular pump 50, 50A, 50B configured to maintain the vacuum chamber 40 in a vacuum. The turbomolecular pump 50, 50A, 50B is provided above the vacuum chamber 40 in a vertical direction.

A mass spectrometer 100 comprises: an ion source 101 that ionizes a sample; a detection unit 105 that has a photomultiplier tube 105a and that analyzes the mass of the sample ionized by the ion source 101; a vacuum chamber 102 that achieves communication between the ion source 101 and the detection unit 105; a vacuum gauge 106 that measures the degree of vacuum inside the vacuum chamber 102; and a data analysis unit 112 and analysis control unit 113 that use electrons emitted from the vacuum gauge 106 to calibrate a setting of the photomultiplier tube 105a.

A mass spectrometer 100 comprises: an ion source 101 that ionizes a sample; a detection unit 105 that has a photomultiplier tube 105a and that analyzes the mass of the sample ionized by the ion source 101; a vacuum chamber 102 that achieves communication between the ion source 101 and the detection unit 105; a vacuum gauge 106 that measures the degree of vacuum inside the vacuum chamber 102; and a data analysis unit 112 and analysis control unit 113 that use electrons emitted from the vacuum gauge 106 to calibrate a setting of the photomultiplier tube 105a.

A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and / or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

The invention provides a cycloidal mass spectrometer and a method for adjusting resolution thereof. The spectrometer comprises a set of magnets, providing a magnetic field; two sets of electrode arrays, opposing to each other parallelly, each set of the electrode array including a plurality of strip electrodes arranged parallelly; at least one DC power supply, providing DC voltages to each set of the electrode array to form a DC electric field, the direction of the electric field being perpendicular to the direction of the magnetic field, and the electric field and the magnetic field superimposed on each other to form an electric-magnetic cross-field; an ion injection unit, configured to inject ions into the electric-magnetic cross-field. Said ions travel along a cycloidal trajectory in the electric-magnetic cross-field, in which the magnetic field intensity and the electric field intensity decrease simultaneously within at least part of the region in said cycloidal trajectory.

An ion trap is provided that comprises a first current source, a first pair of parallel wires that form a plane and have a space between them, each of the wires connected to the first current source such that current flows in opposite directions along each of the parallel wires, a second current source, and a second pair of parallel wires that are disposed in the plane of the first pair of parallel wires and in the space between the first pair of parallel wires, approximately perpendicular to the first pair of wires, and connected to the second current source such that each of the second pair of parallel wires flows in opposite directions along each of the second pair of parallel wires, At a center point of the first pair of parallel wires and the second pair of parallel wires, a magnetic field generated by a current from the first current source passing through the first pair of parallel wires is in an opposite direction to a magnetic field generated by a current from the second current source passing through the second pair of parallel wires.

The present invention discloses a method for rapid on-site detection of fentanyl analogs using a miniature mass spectrometer, comprising the following steps: (1) selecting a spotting plate; (2) loading a sample: depositing the sample and 3-nitrobenzonitrile solution in acetonitrile on the spotting plate to form a crystalline mixture; (3) carrying out analysis and detection: setting the parameters of the miniature mass spectrometer, placing the crystalline mixture on the spotting plate in close proximity to the inlet of the miniature mass spectrometer, and facilitating the ionization of the crystalline mixture for the analysis and detection of fentanyl analogs. The method for rapid on-site detection of fentanyl analogs using a miniature mass spectrometer provided by the present invention requires no extraction solvent, no voltage, no laser, no gas, and the method is simple, rapid, and suitable for rapid on-site detection of fentanyl analogs.

The invention generally relates to systems and methods for analyzing operational status of an electronic instrument. In certain embodiments, the invention provides systems that include a sampling module that operable couples to an electronic instrument in a manner that the sampling module receives a vapor emitted from the electronic instrument, the sampling module comprising an ionization source and one or more mass analyzers to thereby produce a chemical signature of one or more analytes in the vapor; and an analysis module operable coupled to the sampling module to receive the chemical signature of the one or more analytes in the vapor and compare the received chemical signature to a database of known chemical signatures to thereby determine operational status of the electronic instrument.

A mass spectrometry system that includes an ion source that produces ions, an ion transfer device, and a mass analyzer. The ion transfer device includes a first ion transfer device that receives ions from an inlet and transfers ions to an outlet, and includes a plurality of first plate electrodes that are stacked, each plate electrode having a hole with a same diameter, and separated by a first inter-electrode spacing such that the hole diameter is between 1 to 100 times the first inter-electrode spacing; a second ion transfer device receives and transfers the ions, and includes a plurality of second plate electrodes with holes having a same diameter, separated by a second inter-electrode spacing such that the hole diameter is between 3 to 100 times the second inter-electrode spacing; and a third ion transfer device includes a plurality of third plate electrodes with holes having a plurality of diameters.

What is disclosed herein are quadrupole mass filters (QMF) and related methods. The QMFs may have a relatively high surface roughness and / or be additively manufactured, wherein the QMF may be configured for ion filtering in a mass spectrometer. The methods may comprise: a. applying transverse sections to produce a dielectric part; b. masking one or more surfaces of the dielectric part to produce a partially masked dielectric part; c. positioning a metal on the partially masked dielectric part with a metal conductor to produce one or more electrically conductive surfaces on the printed part; and d. removing the mask from the printed part to produce a finished QMF; wherein the QMF is configured for ion filtering in a mass spectrometer.

A system and method for spectrometry of a sample in a plasma is described. The system includes a split ring resonator, an electrode, and a delivery system. The split ring resonator has a discharge gap, and the electrode is arranged in proximity to, but spaced apart from, the discharge gap such that. When a sufficient power is supplied to a plasma generated in the discharge gap, the plasma extends towards and couples with the electrode, so that the plasma is established in a region between the discharge gap and the electrode. The delivery system is for introduction of a sample into the plasma established in the region between the discharge gap and the electrode. The system is configured to direct an output from the plasma to a spectrometer for analysis.

A mass spectrometer (10), (10A), (10B) is provided with: an ion source (30); a vacuum chamber (40) into which the sample ionized by the ion source (30) is introduced; and turbo molecular pumps (50), (50A), (50B) that hold the vacuum chamber (40) in a vacuum state, the turbo molecular pumps (50), (50A), (50B) being provided above the vacuum chamber (40) in the vertical direction.

The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.

An ion optical element 10, which may form an ion acceleration region for a Time of Flight mass spectrometer, comprises a set of stacked electrodes 110 having apertures 111 therethrough (e.g. a ring st

An ion transfer device of a mass spectrometry system that includes a first ion guide such that the first ion guide traps the ions in a first potential well formed by a first potential gradient and a first potential barrier within the first ion guide, and a second ion guide that receives the ions from the first ion guide if the first potential barrier is reduced such that during a time period when the ions travel toward one end of the second ion guide, a second potential barrier is gradually formed by increasing a third voltage applied to a third electrode at the one end of the second ion guide, the second potential barrier preventing the ions from exiting the second ion guide or from colliding with the third electrode.

The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.

There is provided an ion trap comprising a first current source, a first pair of parallel wires (1, 2) forming a plane and having a space therebetween, each of the wires being connected to the first current source such that current flows in opposite directions along each of the parallel wires, a second current source; and a second pair of parallel wires (3, 4) arranged in the plane of the first pair of parallel wires and in the space between the first pair of parallel wires and being substantially perpendicular to the first pair of wires, each of the second pair of wires being connected to the second current source such that each of the second pair current flows in opposite directions along each of the second pair of parallel wires. The magnetic field generated by the current from the first current source through the first pair of parallel wires, at a centre point of the first pair of parallel wires and the second pair of parallel wires, is opposite in direction from the magnetic field generated by the current from the second current source through the second pair of parallel wires.

This invention relates to the field of liquid chromatography-mass spectrometry (LC-MS), specifically a small LC-MS based on high-precision voltage measurement. It includes a housing with a shell bolted to the top. Inside the shell are a primary chamber, a secondary chamber, and a mounting area, arranged vertically. An ion funnel is located inside the primary chamber, and a conical plate is bolted to the top of the inner wall of the secondary chamber. The linear ion trap of this invention is a dual-potential-well plane, capable of separately collecting incoming ions and controlling the cooling and ejection of confined ions. Compared to a single-potential-well plane ion trap, it provides more thorough ion collection and focusing. Furthermore, the working cycle, ion flux, and ejected ions of the dual-potential-well plane ion trap meet the requirements of a multiple reflection time-of-flight mass spectrometer (MRFMS), and it can be coupled to provide high-flux, state-concentrated introduced ions, significantly improving the detection accuracy and precision of the LC-MS.

The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

The present invention relates to the technical field of mass spectrometers, and provides a mass spectrometer, comprising: a first vacuum chamber, having an atmospheric pressure interface connected to an external atmospheric pressure environment, and connected to a first vacuum pump, wherein the working pressure P1 of the first vacuum chamber is in the range of P1>30 mbar; a second vacuum chamber, connected to the first vacuum chamber by a vacuum interface to receive an analyte from the first vacuum chamber, the second vacuum chamber is connected to a second vacuum pump, and the working pressure P2 of the second vacuum chamber is in the range of 0.5 mbar≤P2≤30 mbar; and a third vacuum chamber, connected to the second vacuum chamber by a vacuum interface to receive an analyte from the second vacuum chamber, the third vacuum chamber is connected to a third vacuum pump, the first vacuum pump or the second vacuum pump is used as a pre-pump of the third vacuum pump, and through a multi-stage vacuum chamber design combined with the working pressure design of each stage of the vacuum chamber, the sensitivity of the mass spectrometer is ensured while the miniaturization design of the mass spectrometer is realized.

A mass spectrometry system including an ion transfer device that receives the ions and produces a plurality of ion packets, such that the ion transfer device receives the ions from an inlet of the ion transfer device, forms a first ion packet, and delivers the first ion packet to an outlet, such that during the time when the ion transfer device delivers the first ion packet via the outlet of the ion transfer device, the ion transfer device simultaneously receives the ions from the inlet to form a second ion packet inside the ion transfer device from the received ions, the second ion packet is separate from the first ion packet, and such that the ion transfer device delivers each of the plurality of ion packets to the outlet of the ion transfer device at a frequency in a range from 1 Hz to 1000 Hz.

A mass spectrometer (100) is provided with: an ion source (101) that ionizes a sample; a detection unit (105) that has a photomultiplier tube (105a) and analyzes the mass of the sample ionized by the ion source (101); a vacuum chamber (102) that connects the ion source (101) and the detection unit (105); a vacuum gauge (106) that measures the degree of vacuum inside the vacuum chamber (102); and a data analysis unit (112) and an analysis control unit (113) that corrects the setting of the photomultiplier tube (105a) using the electrons radiated from the vacuum gauge (106).

Example ion trap chips and quantum computing methods are described. One example ion trap chip includes a plurality of first ion traps and a plurality of second ion traps. Each first ion trap is configured to store an operation ion, where two adjacent first ion traps form one ion trap group. Each second ion trap corresponds to one ion trap group. Each second ion trap is configured to perform quantum operations of operation ions stored in a corresponding ion trap group, and each second ion trap is located between two first ion traps in a corresponding ion trap group. Operation ions stored in first ion traps in an ion trap group are transported to a corresponding second ion trap along a straight line.

There is provided an ion trap comprising a first current source, a first pair of parallel wires forming a plane and having a space therebetween, each of the wires being connected to the first current source such that current flows in opposite directions along each of the parallel wires, a second current source; and a second pair of parallel wires arranged in the plane of the first pair of parallel wires and in the space between the first pair of parallel wires and being substantially perpendicular to the first pair of wires, each of the second pair of wires being connected to the second current source such that each of the second pair current flows in opposite directions along each of the second pair of parallel wires.

A collision / reaction cell (CRC) 53 for a mass spectrometer, the CRC 53 comprising a first multipole RF ion guide 531, a second multipole RF ion guide 532 and a third multipole RF ion guide 533 dispo