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Discontinuous atmospheric pressure interface

An atmospheric pressure, interface technology, used in the separation of different isotopic elements, electrical components, parts of particle separator tubes, etc., can solve problems such as high noise, arc generation, short life of electron multipliers and power supplies

Active Publication Date: 2010-09-01
PURDUE RES FOUND INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the efficiency of the API itself is not improved, the final ion flux to the mass analyzer is significantly increased
However, at high voltages, the possibility of arcing in vacuum increases, which results in high noise and short lifetimes of electron multipliers and power supplies

Method used

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Embodiment Construction

[0053] For ion trap type mass spectrometers, the pumping capacity cannot be efficiently utilized with conventional normally open APIs. Ions are typically allowed to enter the ion trap for only a portion of each scan cycle, however neutrals are constantly leaking into the vacuum manifold and need to be pumped away to maintain the low pressures typically required for mass analysis. Although mass analysis using ion traps typically requires an ideal pressure of a few millitorr or less, ions can be trapped at pressures much higher than this ideal pressure. (Shaffer, S.A.; Tang, K.Q.; Anderson, G.A.; Prior, D.C.; Udseth, H.R.; Smith, R.D. Rapid Communications in Mass Spectrometry1997, 11, 1813-1817) Using this property of ion traps, an alternative Atmospheric pressure interface, the Discontinuous Atmospheric Pressure Interface (DAPI), to achieve maximum ion transmission at the specified pumping capacity of a mass spectrometer with ion trapping components. The concept of a discrete ...

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Abstract

A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

Description

[0001] related application [0002] This application requires filing with the United States on June 1, 2007 and August 3, 2007, respectively [0003] Priority to U.S. Provisional Patent Application Nos. 60 / 941,310 and 60 / 953,822 filed in the Patent and Trademark Office, both of which are hereby incorporated by reference in their entirety. [0004] governmental support [0005] At least a portion of the invention described herein was supported by the US Department of Homeland Security (grant number: HSHQPA-05-9-0033). The government has certain rights in this invention. technical field [0006] The present invention generally relates to improvements in the introduction of ions into mass spectrometers. Background technique [0007] The atmospheric pressure interface (API) of the mass spectrometer is used to transfer ions from the atmospheric (atmospheric) region to [0008] Move to other low pressure areas. It allowed the development and use of a variety of ionization sou...

Claims

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Application Information

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IPC IPC(8): B01D59/44H01J49/00
CPCH01J49/0031H01J49/0495H01J49/10H01J49/0013H01J49/0027H01J49/0422H01J49/0404H01J49/00H01J49/04H01J49/24H01J49/004H01J49/165H01J49/26
Inventor Z·欧阳L·高罗伯特·格雷厄姆·库克斯
Owner PURDUE RES FOUND INC
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