The invention relates to the fracturing technology, in particular to a chemical and physical combined explosion fracturing device and a manufacturing method of the chemical and physical combined explosion fracturing device. The chemical and physical combined explosion fracturing device and the manufacturing method of the chemical and physical combined explosion fracturing device resolve the problems at the existing fracturing technology is limited in fracturing effect, narrow in application range and poor in use safety. The chemical and physical combined explosion fracturing device comprises a fracturing device outer shell, wherein the front portion of an inner cavity of the fracturing device outer shell is in interference fit with a powder chamber outer barrel, an inner cavity of the powder chamber outer barrel is provided with a powder screening pipe in a sleeved mode, a first explosion film is arranged on an opening in the rear end of the powder screening pipe in a sealing mode, an inner cavity of the powder screening pipe is filled with a powder pillar which is connected with an ignition line, a pressing nut is arranged on an opening in the rear end of the fracturing device outer shell in a sealing mode, a through hole penetrating through the front portion and the rear portion is formed between the front end surface and the rear end surface of the pressing nut, a second fracturing film is arranged on the through hole in a sealing mode, and the rear portion of the inner cavity of the fracturing device outer shell is filled with high-pressure CO2 in a sealing mode. The chemical and physical combined explosion fracturing device and the manufacturing method of the chemical and physical combined explosion fracturing device are suitable for the development of petroleum, natural gas, coal bed gas, shale gas and the like, and suitable for a pre-fracturing and permeability-increasing process of extraction of coal bed gas under a coal mine shaft.