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This application relates to the field of wastewater treatment technology, specifically providing a method and system for the synergistic oxidation-reduction coupling treatment of ethylthionitrogen-C-N-S in mineral processing wastewater using a MABR oxygen stratification process. This method and system innovatively develops a time-sequential dissolved oxygen (DO) dynamic control strategy: by periodically / pulsally switching anaerobic-hypoxic-aerobic conditions, the oxidation and ammonification reactions of ethylthionitrogen are directionally enhanced, and the toxic inhibitory effects of intermediate products on functional bacteria are eliminated. Based on this strategy, the system can precisely utilize the spatial distribution of the biofilm oxygen gradient within a single MABR reactor to achieve a cascade reaction of ethylthionitrogen: "sulfur oxidation-ammonification → aerobic nitrification → anoxic denitrification"; or, for high-concentration ethylthionitrogen (>50 mg / L), it can couple a pre-anaerobic reactor to enhance ammonification detoxification and denitrification.