The invention discloses a processing method of an interleaving paper product. The processing method comprises the steps of: mixing polyacrylate with a fluorocarbon chain to generate a waterproof agent, and after leaching an auxiliary assistant, drying to generate a waterproof membrane; after reacting various paper pulp or virgin pulp with a papermaking assistant, baking and pressing to generate a paper surface layer; and pasting or fixedly bonding an isolating layer with the paper surface layer to effectively prevent water seepage and the like. The production process is simple, and the isolating layer is of a thin film structure, so that the thickness of the paper product cannot be affected, the production cost cannot be increased, and a wide range of promotion and use is convenient; According to the interleaving paper towel provided by the invention, the problem of preventing water seepage of various facial paper towels, wet paper towels, toilet paper and pharmaceutical paper can be effectively solved, the normal use of the paper towels cannot be affected due to the damage to the paper surface layer in the using process, meanwhile, the single-sided use of double-sided paper towels (comprising the wet paper towels) is satisfied, the negative effects such as permeation cannot be produced on the unused other side, and the purpose of the use of the double-sided paper is truly achieved, so that resources are effectively saved, and the interleaving paper towel has a wide marketization prospect.