Traditional Chinese medicine composition for preparing antidiabetic nephropathy product and preparation method and application of traditional Chinese medicine composition
A technology for diabetic nephropathy and anti-diabetes, which is applied in the field of traditional Chinese medicine prescriptions for the preparation of anti-diabetic nephropathy products and its preparation and use, can solve the problems of progressive aggravation, abnormal metabolism, abnormal metabolism of vasoactive substances, etc., and achieve economic relief. Pressure, simple preparation process, and the effect of improving the quality of life
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[0414] In order to further set forth the preparation method of the present invention, further set forth below:
[0415] The preparation method of the traditional Chinese medicine prescription of the present invention is to take the raw materials of Chinese medicinal materials in parts by weight, and prepare by water extraction and alcohol precipitation to obtain the Chinese medicine extract, extract or dry powder. The preparation method is as follows:
[0416] (1) Weigh 3-6kg of astragalus, 3-6kg of Rehmannia glutinosa, 1.5-3kg of dogwood, 1-2kg of dodder, 1-2kg of Puhuang, 3-6kg of salvia miltiorrhiza, 1.5-3kg of ghost arrow feather, 3-6kg of berberine, corn Mustard 3-6kg, Achyranthes bidentata 1.5-3kg, combine all medicinal materials;
[0417] (2) Add water to decoct 2 to 3 times, each time adding water is 10 to 15 times the total weight of medicinal materials, decoct for 1 to 3 hours, and combine the decoction;
[0418] (3) Concentrate under reduced pressure under the cond...
Embodiment 1
[0423] Embodiment 1, the preparation of Chinese medicine extract
[0424] Weigh astragalus 3kg, rehmannia glutinosa 3kg, dogwood 1.5kg, dodder 1kg, puhuang 1kg, salvia miltiorrhiza 3kg, ghost arrow feather 1.5kg, coptis 3kg, corn silk 3kg, achyranthes bidentata 1.5kg. Combine all the medicinal materials, add water to decoct twice, add water for the first time to 12 times the total weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the total weight of the medicinal materials, decoct for 1.5 hours, combine the decoction, Under the condition of 0.08MPa and concentrated under reduced pressure to 65°C, the relative density is 1.15, add 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stir, stand overnight, filter, and the filtrate is in Concentrate under reduced pressure at 0.08MPa to recover ethanol, and continue to concentrate to a thick paste, dry, pulverize and pass through a 100-mesh sieve to obtain dry powder of the ...
Embodiment 2
[0425] Example 2, the curative effect evaluation experiment of Shenqi No. 1
[0426] Efficacy evaluation of "Shenqi Ⅰ" in the treatment of early and middle stage diabetic nephropathy (DNⅢ-Ⅳ stage)
[0427] 1. Source of cases: 80 DN cases met the inclusion criteria in outpatient or inpatient departments of Traditional Chinese Medicine and Nephrology in Punan Hospital from 2014 to 2015.
[0428] 2. Western medicine diagnostic criteria:
[0429] 2.1 According to the type 2 diabetes standard established by ADA (American Diabetes Association) in 2010: glycosylated hemoglobin Alc≥6.5% or fasting blood glucose FPG≥7.0mmol / l (fasting is defined as no calorie intake for at least 8 hours) or oral glucose tolerance test 2h blood glucose ≥ 11.1mmol / l, or in patients with typical symptoms of hyperglycemia, random blood glucose ≥ 11.1mmol / l.
[0430] 2.2 According to the Mogensen staging criteria, patients with early and mid-stage DN who meet stage II-IV:
[0431] Stage II: normal albumi...
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