Method for preparing 20(R)-25-hydroxy-dammarane type-3beta,12beta,20-triols

Abstract

The invention provides a method for preparing protopanoxadiol derivatives of a formula below, namely 20(R)-25-hydroxy-dammarane type-3beta,12beta,20-triols[abbreviated as 20(R)-25-OH-PPD]. The protopanoxadiol derivatives are obtained by hydrolyzing total ginsenoside, wherein the method for hydrolyzing the total ginsenoside comprises a basic hydrolysis process, an acid hydrolysis process I and an acid hydrolysis process II. The structure of the 20(R)-25-hydroxy-dammarane type-3beta,12beta,20-triols is determined by nuclear magnetic resonance spectrum. The method is high in yield and purity, ensures stable product quality and can realize industrial production and can meet the needs for development of new antitumor medicines.

Description

Preparation method of 20(R)-25-hydroxy-dammarane type-3β,12β,20-triol This application is the application number of Liaoning Xinzhong Modern Medicine Co., Ltd. on August 7, 2006. Preparation method" divisional application. technical field The present invention relates to a preparation method of protopanaxadiol derivative 20(R)-25-hydroxyl-dammarane type-3β,12β,20-triol [20(R)-25-OH-PPD for short] . Its preparation method includes A: silica gel chromatography; B: alkali hydrolysis method, after acid neutralization, organic solvent extraction and silica gel column chromatography separation, 20(R)-25-OH-PPD white crystals are obtained; C, acid hydrolysis Method I, 20(R)-25-OH-PPD is obtained after alkali neutralization, organic solvent extraction and silica gel column chromatography separation; D, acid hydrolysis method II, add water to precipitate, wash with water until the neutral precipitate passes through the silica gel column layer After analysis and separation, white c...

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Problems solved by technology

However, due to the difficulty in obtaining a large amount of C-K and protopanaxadiol,

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