Method for preparing medicine sustained-releasing bracket

Abstract

A preparation method of a drug sustained-release stent includes a preparation stent, a drug sustained-release stent constituted by drug coating on the stent, and the drug coating of the stent is composed of the following steps sequentially: (1) the preparation of a sustained-release drug coating layer; (2) the coating of the sustained-release drug coating layer; (3) drying. The dosages of the drug components on the sustained-release drug stent of the invention are in line with the designed dosages, and the drug can be released according to the stipulated dosages in the stipulated time of the design requirements completely in vitro tests. The invention has good biocompatibility, low cost of spraying process, high yield, controllable thickness of the coating layer, and slow and stable drug release rate.

Description

technical field

[0001] The invention belongs to the field of drugs and medical devices (interventional medical devices), and relates to a drug-eluting stent capable of reducing neointima proliferation and treating vascular restenosis, in particular to an anti-oxidative drug slow-release stent and a preparation method thereof . Background technique

[0002] With the improvement of living standards, the number of patients with coronary heart disease is increasing. At present, Percutaneous Coronary Intervention (PCI) has become one of the conventional treatment methods for coronary heart disease, and the success rate can reach more than 95%. However, 25-50% of patients will develop restenosis 3-6 months after surgery, which limits the long-term efficacy of PCI.

[0003] The mechanism of restenosis after stenting is: the expansion of human blood vessels by stents or other implanted devices causes damage to endothelial cells and smooth muscle cells in the blood vessel wall, whic...