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A compound chlortetracycline and oil-in-water technology, applied in the field of medicine, can solve the problems of increased administration frequency and administration dosage, poor water solubility of chlortetracycline, poor bioavailability, etc. The effect of reducing kidney damage and improving antibacterial ability
Inactive Publication Date: 2015-02-18
HENAN SOAR VETERINARY PHARMA
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However, chlortetracycline has poor water solubility, is often difficult to be absorbed and transported by the body, and has extremely poor bioavailability. When used a
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Embodiment 1
[0032] An oil-in-water type compound aureomycin nanoemulsion, which consists of 6 parts of Magnolia bark water extract, 32 parts of surfactant (EL40), 4 parts of cosurfactant (ethanol), and 7 parts of aureomycin , oil (fatty acid glycerides) 11 parts, distilled water 40 parts.
[0033] Its preparation method is as follows:
[0034] 1) Weigh Magnolia officinalis water extract, surfactant, co-surfactant, chlortetracycline, oil and distilled water according to the above;
[0035] 2) Stir the surfactant, co-surfactant, chlortetracycline and oil evenly at room temperature to obtain an oil phase solution;
[0036] 3) Dissolving the Magnolia officinalis water extract in distilled water to obtain a distilled water phase solution;
[0037] 4) Add the distilled water phase solution into the oil phase solution and stir evenly to obtain the nanoemulsion.
Embodiment 2
[0039] An oil-in-water type compound aureomycin nanoemulsion, which consists of 5 parts of Magnolia bark water extract, 35 parts of surfactant (EL40), 5 parts of co-surfactant (1,2-propylene glycol), gold 5.5 parts of mycin, 14 parts of oil (ethyl butyrate), 35.5 parts of distilled water.
[0040] Its preparation method is with embodiment 1.
Embodiment 3
[0042] A kind of oil-in-water compound aureomycin nanoemulsion, its weight composition is: 4.5 parts of Magnolia bark water extract, 40 parts of surfactant (RH40), 5 parts of co-surfactant (glycerol), chlortetracycline 5.5 parts, 9 parts of oil (ethyl acetate), 36 parts of distilled water.
[0043] Its preparation method is with embodiment 1.
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Abstract
The invention discloses oil-in-water compound chlortetracycline nanoemulsion, and belongs to the technical field of medicines. The oil-in-water compound chlortetracycline nanoemulsion comprises the following components in parts by weight: 1-18 parts of aqueous magnolia officinalis extract, 25-45 parts of a surfactant, 0-20 parts of a co-surfactant, 1-20 parts of chlortetracycline, 1-20 parts of oil and 20-70 parts of water. The oil-in-water compound chlortetracycline nanoemulsion has relatively narrow emulsion particle size distribution, is transparent, has high stability, relatively low surface tension and good mobility, and is convenient to take; a nanoemulsion preparation improves solubility and permeability of the chlortetracycline, so that the bioavailability of a medicine is improved; after the aqueous magnolia officinalis extract and the chlortetracycline are compounded, antibacterial abilities of the aqueous magnolia officinalis extract and the chlortetracycline are mutually promoted and enhanced, so that the antibacterial effect of the oil-in-water compound chlortetracycline nanoemulsion is more stable.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oil-in-water nanoemulsion-a compound antibacterial nanoemulsion with magnolia bark water extract and aureomycin as active ingredients. Background technique [0002] Aureomycin, English / Latin names: Chlortetracycline, Chlortetracycline, Aureomycin. CAS number: 57-62-5. EINECS No.: 200-341-7. Molecular formula: C 22 h 23 ClN 2 o 8 . Molecular weight: 478.8796. [0003] Chlortetracycline is a tetracycline antibiotic. Many rickettsia, mycoplasma, chlamydia, atypical mycobacteria, and spirochetes are sensitive to this product. Enterococci are resistant to it. Due to the widespread use of tetracyclines over the years, common clinical pathogens are seriously resistant to aureomycin, and Gram-positive bacteria such as Staphylococcus and most Enterobacteriaceae are drug-resistant. There is cross-resistance between this product and different varieties of tetracycl...
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