Clathrate compound of aureomycin zinc complex, and preparation method thereof

A technology of chlortetracycline zinc and complexes, which is applied in the field of drug preparation, can solve the problems of poor solubility and low dissolution rate of chlortetracycline zinc complexes, and achieve improved drug bioavailability, reduced dosage, and reduced drug side effects Effect

Active Publication Date: 2015-03-11
CHONGQING ACAD OF ANIMAL SCI +2
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in the present invention is that the chlor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Clathrate compound of aureomycin zinc complex, and preparation method thereof
  • Clathrate compound of aureomycin zinc complex, and preparation method thereof
  • Clathrate compound of aureomycin zinc complex, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of clathrate of the present invention

[0025] Weigh 10 grams of chlortetracycline zinc complex, add 48 ml of methanol, 48 ml of dimethyl sulfoxide, 2 ml of N,N-dimethylformamide, and 2 ml of tetrahydrofuran into a mixed organic solvent, and dissolve it completely , kept at 55°C, dripped a saturated aqueous solution containing 14 grams of hydroxypropyl-β-cyclodextrin, stirred at 55°C for 2 hours, stopped heating, and continued to stir to room temperature to obtain a yellow solution, which was filtered and spray-dried to obtain gold Inclusion complexes of mycin zinc complexes.

Embodiment 2

[0026] Embodiment 2 Preparation of clathrate of the present invention

[0027] Weigh 10 grams of chlortetracycline zinc complex, add 48 ml of methanol, 48 ml of dimethyl sulfoxide, 2 ml of N,N-dimethylformamide, and 2 ml of tetrahydrofuran into a mixed organic solvent, and dissolve it completely , kept at 60°C, dripped a saturated aqueous solution containing 28 grams of hydroxypropyl-β-cyclodextrin, continued to stir for 30 minutes, stopped heating, and continued to stir to room temperature to obtain a yellow solution, which was filtered and freeze-dried, which was Golden Mold Inclusion complexes of zinc complexes.

Embodiment 3

[0028] Embodiment 3 Preparation of clathrate of the present invention

[0029] Weigh 10 grams of chlortetracycline zinc complex, add 48 ml of methanol, 48 ml of dimethyl sulfoxide, 2 ml of N,N-dimethylformamide, and 2 ml of tetrahydrofuran into a mixed organic solvent, and dissolve it completely , kept at 60°C, dripped a saturated aqueous solution containing 28 grams of hydroxypropyl-β-cyclodextrin, ultrasonicated at 65°C for 30 minutes, filtered through a 0.45 μm membrane, and the resulting solution was spray-dried to obtain aureomycin Inclusion complexes of zinc complexes.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of drug preparation, particularly relates to a clathrate compound of an aureomycin zinc complex, and a preparation method thereof, and aims to solve the technical problem that the aureomycin zinc complex is poor in solubility and small in dissolution rate. Through the technical scheme, the clathrate compound of the aureomycin zinc complex comprises a clathrate material and the aureomycin zinc complex according to a weight ratio of (1-3): 1, and the clathrate material is cyclodextrin or a cyclodextrin derivative. The invention further provides an oral preparation prepared from the clathrate compound. The invention further provides a preparation method for the clathrate compound of the aureomycin zinc complex. The aureomycin zinc complex in the clathrate compound is good in solubility in water and high in dissolution rate, and has the advantages of good water solubility, high stability, good curative effect, little side effect and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an inclusion compound of a chlortetracycline zinc complex and a preparation method thereof. Background technique [0002] Tetracyclines (Tetracyclines) are named after the chemical structure of tetracene mother nucleus, and aureomycin (Chlortetracycline, structure see figure 1 ), also known as chlorotetracycline, is a kind of tetracycline derivative, which mainly inhibits the protein synthesis of sensitive microorganisms. Chlortetracycline has a broad antibacterial spectrum, and can inhibit Gram-positive bacteria, negative bacteria, spirochetes, rickettsia, mycoplasma, chlamydia, and some protozoa. Chlortetracycline mainly binds to the A site of the 30S small subunit of microorganisms, and then interferes with the combination of aminophthalein tRNA and the 30S small subunit, so that aminophthalein tRNA cannot enter the receptor on the mRNA, and inhibits ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/48A61K31/65A61P31/04
Inventor 伍涛杨旭李书至
Owner CHONGQING ACAD OF ANIMAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap