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Rumen bypass chlortetracycline micro-pills and preparation method thereof

The technology of chlortetracycline and chlortetracycline is applied in the field of rumen-passing chlortetracycline pellets and the preparation thereof, which can solve the problems of inconvenient operation, animal stress reaction, and high cost of injection preparations, and achieves easy acquisition and preparation technology. Simple, easy-to-control product quality

Inactive Publication Date: 2016-10-12
ZHUMADIAN HUAZHONG CHIA TAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To achieve the effect of disease resistance and growth promotion, the only way is to inject chlortetracycline, but currently chlortetracycline injection products are rare, and injection preparations are costly, inconvenient to operate, and easily cause stress reactions in animals

Method used

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  • Rumen bypass chlortetracycline micro-pills and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A rumen-passed aureomycin pellet, comprising the following components:

[0021] Pill core containing medicine: chlortetracycline 1kg, corn starch 1kg, calcium carbonate 3kg, hypromellose 0.08kg, microcrystalline cellulose (binder) 0.5kg,

[0022] Coating material: 0.5kg of acrylic resin IV (manufacturer: Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.), 0.2kg of ethyl cellulose.

[0023] Acrylic resins include many different models, such as acrylic resin IV and Eudragit E used in the present invention, all of which can be purchased commercially.

[0024] The preparation method is as follows:

[0025] (1) Preparation of ball core:

[0026] Dissolve hypromellose in water to prepare an aqueous solution with a concentration of 1.0 wt%, and use a three-dimensional mixer to mix chlortetracycline, cornstarch, calcium carbonate, and microcrystalline cellulose, and the material loading does not exceed 1% of the volume of the mixer. 2 / 3, speed 60r / min, mix for 10 minutes, ...

Embodiment 2

[0030] A rumen-passed aureomycin pellet, comprising the following components:

[0031] Pill core containing medicine: chlortetracycline 1.6kg, corn starch 2.0kg, calcium carbonate 3.5kg, hypromellose 0.2kg, microcrystalline cellulose (binder) 0.7kg,

[0032] Coating materials: Acrylic resin IV 1kg (manufacturer: Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.), ethyl cellulose 0.4kg, talcum powder 0.15kg.

[0033] The preparation method is as follows:

[0034] (1) Preparation of ball core:

[0035] Dissolving hypromellose in water and preparing an aqueous solution with a concentration of 1.3wt%, using a three-dimensional mixer to mix chlortetracycline, cornstarch, calcium carbonate, and microcrystalline cellulose, and the material loading does not exceed 1% of the volume of the mixer. 2 / 3, speed 60r / min, mix for 10 minutes, mix the mixed material with the prepared hypromellose aqueous solution again, use centrifugal shot blasting machine to granulate in one step, fan fre...

Embodiment 3

[0039] A rumen-passed aureomycin pellet, comprising the following components:

[0040] Pill core with medicine: chlortetracycline 2.5kg, corn starch 3kg, calcium carbonate 4kg, hypromellose 0.32kg, maltodextrin (binder) 1kg,

[0041] Coating materials: EudragitE 1.5kg (manufacturer: Evonik Specialty Chemicals (Shanghai) Co., Ltd.), ethyl cellulose 0.7kg, talcum powder 0.3kg.

[0042] The preparation method is as follows:

[0043] (1) Preparation of ball core:

[0044] Dissolve hypromellose in water to prepare an aqueous solution with a concentration of 1.6wt%, and use a three-dimensional mixer to mix chlortetracycline, cornstarch, calcium carbonate, and maltodextrin evenly, and the material loading does not exceed 2% of the volume of the mixer. / 3, speed 60r / min, mix for 10 minutes, mix the mixed material with the prepared hypromellose aqueous solution again, use centrifugal shot blasting machine to granulate in one step, fan frequency 20Hz, speed 150r / min , then dried at 9...

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Abstract

The invention aims at providing rumen bypass chlortetracycline micro-pills and a preparation method thereof. The rumen bypass chlortetracycline micro-pills sequentially comprise drug-containing pill cores and coating layers from inside to outside, wherein the drug-containing pill cores are prepared from, by weight, 10-25 parts of chlortetracycline, 10-30 parts of corn starch, 30-40 parts of calcium carbonate, 0.8-3.2 parts of hydroxypropyl methylcellulose, 5-10 parts of adhesive and 7-25 parts of coating layer. The coating layers of the rumen bypass chlortetracycline micro-pills prepared by means of the preparation method are complete in rumen, and no chlortetracycline is released; then the micro-pills reach the stomach, the coating layers are damaged in a gastric acid environment, the chlortetracycline is released, and accordingly antibacterial and growth-promoting effects are achieved; meanwhile, the physiological habits of ruminants are not affected, and the micro-pills are convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medicines for livestock and poultry, and in particular relates to rumen-passed aureomycin pellets and a preparation method thereof. Background technique [0002] Aureomycin is a kind of tetracycline antibiotics, which is a broad-spectrum antibiotic. Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria, and spirochetes are sensitive to aureomycin, and enterococci are sensitive to aureomycin. drug resistance. Chlortetracyclines can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of the peptide chain, and then affect the synthesis of bacterial proteins, thereby exerting their effects. [0003] Chlortetracycline is usually added to livestock and poultry feed in the form of a premix to promote growth. For ruminants, before the rumen is formed, a certain proportion of aureomycin can be added to the feed to promote growth, improve immunity, and treat res...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/38A61K31/65A61P11/00A61P1/12A61P31/04
CPCA61K9/5026A61K9/5042A61K31/65A61K47/38
Inventor 白雪原樊春光陈浩然卜令军
Owner ZHUMADIAN HUAZHONG CHIA TAI
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