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Alternating magnetic field driven shape memory biological degradable polymer and preparation method thereof

A technology of degrading polymers and alternating magnetic fields, applied in the coating and other directions, can solve the problems of low deformation, inability to directly heat, long light response time or recovery time, etc., to achieve convenient use process, simplified use cost, high Effects of Restoration and Mechanical Properties

Inactive Publication Date: 2007-12-05
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, most of the biodegradable shape-memory polymers studied are temperature-sensitive shape-memory polymers, which use heat to achieve shape changes, but some specific parts of the human body cannot be directly heated, namely Using traditional methods to introduce hot liquids or gases, non-contact initiation conditions are required
Researchers have used light to generate heat to restore the shape of heat-sensitive shape-memory polymers or introduced photosensitive reactive groups into biodegradable polymer systems to achieve photo-induced shape-memory effects. There are many defects such as low deformation, long light response time or recovery time, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0025] (1) Mix L-lactide, glycolide and ε-caprolactone in a molar ratio of 6:2:2 or 6:1:3, and form random copolymers with different compositions through random copolymerization; Or react ε-caprolactone with a molar ratio of 400:1 and ethylene glycol or glycerol at 130°C for 24 hours to generate a hydroxyl-terminated prepolymer, L-lactide, glycolide and butylated Diacid reaction (molar ratio is 200:1, reaction condition is 110 ℃ for 24 hours) to generate carboxyl-terminated prepolymer, and then add diisocyanate coupling agent or chain extender to synthesize multi- block copolymers.

[0026] (2) Preparation of magnetic nano-Fe by chemical co-precipitation method 3 o 4 , with NH 3 ·H 2 O was used as a precipitant, and ferric salt (FeCl 2 4H 2 O) and ferric salt (FeCl 3 ·6H 2 O) the mixed solution is added into the container, and then 28% (mass fraction) of NH 3 ·H 2 O was added to the container, stirred vigorously, and the water bath was kept at constant temperature. ...

Embodiment approach 2

[0031] Fe 3 o 4 Shape memory effect of nanoparticle / poly-L-lactide-caprolactone-based composites.

[0032] L-lactide / ε-caprolactone with a molar percentage of 80:20 is subjected to ring-opening polymerization under the action of stannous octoate to generate poly-L-lactide / ε-caprolactone random copolymerization with a viscosity-average molecular weight of 280,000 thing. 20nm Fe 3 o 4 Nanoparticles use the method described in condition (2) to make its hair surface coated with a layer of poly L-lactide film, then adopt the method of mechanical blending, the Fe after the surface modification of 10% by weight percentage 3 o 4 Nanoparticles and poly-L-lactide / ε-caprolactone random copolymer with a viscosity average molecular weight of 280,000 were prepared into Fe 3 o 4 Nanoparticles / poly-L-lactide-caprolactone-based composites. The material is heated to 20°C above its melting point, then pressurized at 10MPa and molded, and measured on a self-made stretching device, which i...

Embodiment approach 3

[0034] Fe 3 o 4 Shape memory effect of nanoparticles / poly-L-lactide-glycolide-based composites.

[0035] L-lactide and glycolide are ring-opened and polymerized under the action of stannous octoate at a molar ratio of 80:20 to obtain poly-L-lactide / glycolide copolymer, and its viscosity-average molecular weight is 180,000. 30nm Fe 3 o 4 Nanoparticles use the method described in condition (2) to make its hair surface coated with a layer of poly L-lactide film, then adopt the method of mechanical blending, the Fe after the surface modification of 15% by weight percentage 3 o 4 Nanoparticles and poly-L-lactide-glycolide copolymer with a viscosity average molecular weight of 180,000 were prepared into Fe 3 o 4 Nanoparticles / poly-L-lactide-glycolide-based composites. The material is heated to 20°C above its melting point, then pressurized at 10MPa and molded, and measured on a self-made stretching device, which is placed under an alternating magnetic field and has a sensor f...

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Abstract

The present invention is preparation process of biodegradable alternating magnetic field driven shape memory composite polymer material. The composite polymer material is mixture of copolymer of L-lactide and glycolide and / or epsilon-caprolactone and nanometer Fe3O4 particle coated with poly-L-lactide, polyglycolide or poly-epsilon-caprolactone in the weight ratio of 70-90 to 10-30. Compared with available technology, the present invention has the features of non-contact initiated shape memory function, high restoring ability and mechanical performance suitable for use in medical product, capacity of being used in developing in nuclear magnetic resonance, and targeting function for no-duct conveyance.

Description

(1) Technical field [0001] The invention relates to a new material, specifically a biodegradable material with shape memory function. (2) Background technology [0002] A class of aliphatic polyester represented by polylactic acid and its copolymers has been widely used in the medical field due to its excellent biocompatibility, biodegradability and good mechanical properties. It has been involved in surgical sutures, Internal fixation of fractures, tissue engineering scaffolds, drug controlled release carriers and many other aspects have become the most valued materials in the field of biodegradable medical materials. However, with the emergence of various modern new medical technologies, higher requirements are placed on the performance of materials, and the demand for various functional materials with special properties is gradually increasing. Since Lendlein et al reported on the famous magazine "Science" that the degradable PCL and PDO multi-block copolymers have excel...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08G63/78C08G63/87C08G63/08C08G63/91C08J7/04C08K3/22
Inventor 鲁玺丽孙志洁郑玉峰
Owner HARBIN ENG UNIV
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