Process for preparing fatty polyester with variable degradative speed rate and preparation proces sof product thereof

A technology for the degradation rate of aliphatic polyesters, which is applied in the field of preparing aliphatic polyesters with different degradation rates or its products, which can solve the problems of adverse effects of application, lack of biodegradability, application restrictions, etc., and achieve a small amount of addition , Significant effect of degradation promotion

Active Publication Date: 2005-01-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, copolymers are different from homopolymers in terms of physical and chemical properties, and sometimes even have some adverse effects on applications.
For example, polyethylene glycol (PEG) has good biocompatibility, but it does not have biodegradability. Therefore, it is impossible to completely degrade the aliphatic polyester copolymer containing polyethylene glycol segments. Its application bound to be limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] First add 10mL of ε-caprolactone and stannous octoate with a molar ratio of 1:1000 to ε-caprolactone into the 4 polymerization tubes respectively, and then add trifluoroethylene trifluoride with a concentration of 46.8% and a density of 1.13g / mL respectively. boron ether ether (BF 3 ·OEt 2 ) solution 0, 5, 25, 50 μL, and then placed in an oil bath, under the protection of nitrogen or argon, polymerized at 110°C for 48h. After the polymerization is complete, the polymer is removed from the polymerization tube and placed in air.

[0021] BF 3 ·OEt 2 Amount added (μL)

Embodiment 2

[0023] Weigh 1.0 g of polyε-caprolactone with an initial intrinsic viscosity [η] of 1.02 in 4 conical flasks with stoppers, add 20 mL of benzene, and after it is completely dissolved, add the concentration of 0, 10, 20, and 50 μL of 46.8% boron trifluoride ether solution with a density of 1.13 g / mL, stirred and mixed for 24 hours, transferred the above solution to 4 petri dishes, vacuumed the solvent in a desiccator, and finally Dry in vacuum at 40°C until constant weight.

[0024] The obtained above-mentioned polyε-caprolactone, measured with the test conditions of Example 1, has an intrinsic viscosity [η] of 1.02, 0.85, 0.64, and 0.26, respectively.

Embodiment 3

[0026] Take by weighing tetrahydrofuran as solvent, polystyrene as standard, utilize gel permeation chromatography to measure its weight-average molecular weight Mw to be 42144, the number-average molecular weight Mn is the polyε-caprolactone 1.0g of 12715 in a conical flask with a stopper, Add 20 mL of benzene, and after it is completely dissolved, add 100 μL of boron trifluoride ether solution with a concentration of 46.8% and a density of 1.13 g / mL with a micro-syringe at room temperature, stir magnetically for 24 hours, transfer the solution into a Petri dish, Vacuumize the solvent in a desiccator, and finally vacuum-dry at 40°C until constant weight.

[0027] The obtained above-mentioned polyε-caprolactone was measured by gel permeation chromatography, and its weight-average molecular weight Mw decreased to 8252, and the number-average molecular weight Mn decreased to 2520.

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PUM

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Abstract

The invention relates to a method of preparing acyclic polyesters with different degrading speeds or their products, and the characteristic: in the polymerizing course and/or in processing course of them and their products, adding in lewis acid catalyst in weight percent of 0.1-6%. The method is simple and easy to apply, the addition of the lewis acid catalyst is low and the degrading and accelerating effects of the lewis catalyst are remarkable and the lewis acid catalyst has no effect on the biocompatibility and biodegradability of the acyclic polyester, and according to practical requirements, by adding different quantities of catalyst, it can regulate and control the degrading speed of the acyclic polyester, so as to meet different use requirements, especially able to enlarging the application range of acyclic polyesters with slower degrading speeds, such as poly-epsilon-caprolactone, poly L-lactide, etc.

Description

1. Technical field [0001] The invention belongs to the technical field of polymer degradation control, and in particular relates to a method for preparing aliphatic polyesters with different degradation rates or products thereof. 2. Background technology [0002] Aliphatic polyesters have good biocompatibility and biodegradability, especially biodegradability, so that they are widely used as biomedical materials and environmentally friendly materials. Representative biodegradable aliphatic polyesters mainly include: polyε-caprolactone (PCL), polydioxanone (PPDO), polyglycolide (PGA), polylactide (PLA), poly Butylene succinate (PBS), polyethylene succinate (PES), polybutylene adipate (PBA), and poly-3-hydroxybutyl [P(3-HB)] Wait. The compositional and structural differences of these aliphatic polyesters endow them with different biodegradable properties and uses. For example, polyglycolide degrades quickly in the body and is suitable for surgical sutures and slow-release d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C47/40C08G63/02
Inventor 王玉忠丁颂东杨科珂汪秀丽周茜
Owner SICHUAN UNIV
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