58results about How to "Temperature responsive" patented technology

The invention relates to a method for preparing chemically crosslinked photonic crystal hydrogel with an adjustable color. The method comprises the following steps: (1) dissolving N-isopropylacrylamide, N-hydroxyethyl acrylamide, a cross-linking agent and an emulsifier into deionized water, stirring, warming and keeping warm under the condition at 20-25 DEG C in a nitrogen condition, and then adding an initiator to continue to react for 1-4 hours, and dialyzing, so as to obtain a colloidal crystal hydrogel solution; (2) concentrating the obtained colloidal crystal hydrogel solution, standing at room temperature, adjusting the pH by adopting an NaOH solution, adding a crosslinking agent, evenly mixing, centrifuging, and standing at room temperature after taking, so as to obtain the chemically crosslinked photonic crystal hydrogel. The method is simple in process and low in cost, and the prepared photonic crystal hydrogel has thermosensibility. In addition, the obtained photonic crystal hydrogel is good in stability, and free of hydrolysis, the problem that nano hydrogel is easily decomposed because of ester hydrolysis in 2-hydroxy ethyl acrylate is solved, and the defects of the photonic crystal hydrogel in application are compensated.

The invention relates to a hydrophobic polymer material surface hydrophilicity improving method. In order to solve the problem that material surface hydrophilicity is unendurable in the current blended technology, amphipathic microgel containing thermosensitive core and non thermosensitive core is taken as hydrophile modification ingredient in the invention, and surface hydrophilization modification is carried out on hydrophobic polymer material by casting method and melt blending extrusion method respectively. (1) The casting method includes: dispersion liquid of the microgel and hydrophobic polymer solution are blended, the blended even dispersion liquid is casted into a film in a mold, and solvent is removed, thus obtaining a polymer film. (2) The melt blending extrusion method includes: dry microgel and hydrophilic polymer particles are blended and then put into a rotor internal mixer to be mixed for a short time at certain temperature; the material is crushed into particles after discharging, is extruded into sheet or wire by an extruder and forms film by a hot press. The invention has the advantages of easy technique and reliable treatment effect without a complex device and can effectively improve the surface hydrophilicity of the hydrophobic polymer.

The invention discloses a thermo-sensitive solid amine fiber material as well as a preparation method and application thereof. The thermo-sensitive solid amine fiber material is prepared by introducing amine and thermo-sensitive functional groups to the surface of base fiber through synthesis. By adopting the fiber material, the water absorption rate of the material can be changed and controlled by adjusting the change of ambient temperature, and the fiber material can be also controlled to have different water absorption rates by regulating and controlling different mole ratios of thermo-sensitive groups to amino. The fiber material can be applied to the field of intelligent special fiber products or the field of CO2 adsorption, the highest adsorption capacity of the fiber material to CO2 at 35 DEG C and 40 DEG C can be up to 3.8mmol/g, and moreover, CO2 can be completely desorbed at 70 DEG C within 30 minutes after being adsorbed by using the fiber material, so that the thermo-sensitive solid amine fiber material has the advantages of low desorption energy consumption and rapid desorption velocity.

The invention discloses temperature sensitive type polyion liquid gel and a preparation method thereof, relates to the field of high polymer materials, and particularly relates to temperature responsive polyion liquid gel and a preparation method thereof. The gel can be prepared by the following method: forming ion liquid by glycine of good biocompatibility and choline, and forming vinyl choline-glycine ion liquid monomer by modifying the ion liquid through acrylic acid, and then preparing the temperature sensitive type polyion liquid gel by free radical polymerization with a temperature sensitive material N-isopropyl acrylamide (NIPAAm), taking N,N-methylenebisacrylamide (MBAA) as a cross-linking agent, and potassium persulfate as an initiator. The gel is applied to damage-free desorption of cells.

The invention relates to a preparation method of an ethyl cellulose nano micelle with UCST (upper critical solution temperature). The preparation method comprises the following steps: in an inert gas protective atmosphere, carrying out ring-opening polymerization on the hydroxy group in the ethyl cellulose main chain and caprolactone to obtain a high-molecular graft copolymer, carrying out bromination reaction on the high-molecular polymer to obtain an atom transfer free-radical polymerization high-molecular initiator, carrying out atom transfer free-radical polymerization on N,N-dimethylaminoethyl methacrylate under the initiation action of cuprous bromide, carrying out complete quaterization reaction on the obtained polymer to obtain a graft-block copolymer with UCST temperature responsiveness by using ethyl cellulose as the main chain, and dissolving the graft-block copolymer in water to form the stable nano micelle with UCST temperature responsiveness. The ethyl cellulose nano micelle is biocompatible, bioactive and temperature-responsive, and can be widely used in the fields of drug controlled release carriers, biological intelligent switches, biosensors and the like. The preparation method is simple and easy to implement, can implement industrial production on the raw materials, and has favorable popularization and application value.

The invention belongs to the field of biological materials and nano-materials and particularly relates to a preparation method of a thermo-sensitive chitosan polymer connected with sugar molecules. The method comprises the specific steps of initiating atom transfer radical polymerization (ATRP) of 2-(2-methoxyethoxy) ethylmethacrylate (MEO2MA) and oligo(ethylene glycol) methacrylate (OEGMA) by taking a chitosan bromide (CS-Br) as a macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-Br; initiating the ATRP of hydroxyethyl methacrylate (HEMA) by taking the CS-g-P(MEO2MA-co-OEGMA)-Br as the macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-poly(2-hydroxyethyl methacrylate (PHEMA); performing esterification reaction and click chemistry to obtain a thermo-sensitive copolymer of which chitosan serves as a main chain and galactose is grafted. The polymer has biocompatibility, biodegradability, thermo-sensibility and liver targeting, and the polymer in a water solution can be self-assembled to form micelle, and has a wide application prospect in the fields of medicine controlled release, targeted therapy, biosensors and the like. The preparation method is simple and easy to operate, and has a great popularization and application value. Raw materials can be industrially produced.

The invention relates to a preparation method for preparing hydrogel having magnetism and temperature synergistic stimulus-responding. The method comprises the following steps: firstly preparing Fe3O4magnetic nanoparticles by a coprecipitation method, and adding Fe3O4 magnetic nanoparticles into a PU solution, preparing the PU/Fe3O4 magnetic composite nanofibers by a thermally induced phase separation method, and finally, grafting N-isopropylacrylamide to the PU fiber membrane by ultraviolet radiation grafted polymerization. The large specific surface area and high porosity of the PU nanofibers are used, the hydrogel is beneficial to the diffusion of water molecules during swelling and shrinkage, and the response rate of the hydrogel is greatly improved. The prepared PU-g-PNIPAm/Fe3O4 composite nanofiber hydrogel has dual magnetism and temperature responsiveness by using the temperature sensitivity of N-isopropylacrylamide and the magnetic properties of Fe3O4.

The invention provides a poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the step of carrying out copolymerization synthesis on poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the free radical of hydroxy propyl cellulose-g-acrylic acid, wherein the mass percent between the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the hydroxy propyl cellulose-g-acrylic acid is 10-90%: 90-10%. The obtained hydrogel has the characteristics ofthe two homopolymers and is sensitive for the temperature and the pH; and furthermore, the poly (L-glutamic acid) part in the hydrogel can be biodegradable, so that the material can not be accumulated in the body, and the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel can be taken as a novel intelligent drug release carrier.

The invention discloses a thermo-responsive polypeptoid containing oligomeric polyethylene glycol (OEG) in a side chain and a preparation method of the polypeptoid. A click chemical reaction under ultraviolet light is carried out on a polypeptoid containing acetylenic bonds in a side chain with methoxy oligomeric ethylene glycol mercaptan (OEGX-SH), so that the target thermo-responsive polypeptoidis obtained. The thermo-responsive polypeptoid disclosed by the invention is simple in synthetic route, low in cost, high in purity, high in product yield, stable in property, simple in structure andeasy in regulate and control; the temperature responsiveness is easy to regulate and control; and the thermo-responsive polypeptoid is an excellent thermo-responsive polypeptoid material, and has a wide potential application value and research value.

The invention provides polyamino acid, which has a structure shown in a formula (I). Aminated methoxypolyethylene glycol is used as an initiator for initiating glycine-N-carboxyl anhydride, alanine-N-carboxyl anhydride, leucine-N-carboxyl anhydride or valine-N-carboxyl anhydride for polymerization, so that four polyamino acid-polyethylene glycol-polyamino acid triblock copolymers containing different side chain alkyl groups (H, CH3<->, (CH3)2CHCH2<->and (CH3)2CH<->) can be prepared. The application also provides drug-loaded gel which is prepared from the polyamino acid and an antitumor drug loaded on the polyamino acid. The drug-loaded gel provided by the application is prepared from the polyamino acid, thus having low toxicity and good temperature sensibility.

The invention provides a nano medicine delivery system for photo-thermal chemotherapy combined therapy and a preparation method. The nano medicine delivery system is medicine carrying micelle, whereinthe medicine carrying micelle is prepared by enabling poly-propylene sulfide-b-poly(N-isopropyl acrylamide-co-N,N-dimethacrylamide) of formula (I) as shown in the specification to polymerize by self,and by coating doxorubicin (DOX) and indocyanine green (IGG) in micelle. The nano medicine delivery system is characterized in that under radiation of near-infrared light of 808nm, because of photo-thermal effects of the indocyanine green, a temperature can be increased, a hydrophilic layer on the surface of the micelle can be turned into a hydrophobic layer, and the uptake of tumor cells upon the medicine carrying micelle can be improved; meanwhile, the medicine carrying micelle can be oxidized by singlet oxygen generated from the indocyanine green in lighting, and thus medicine release canbe promoted. The nano medicine delivery system has the characteristics of dual responsiveness, combined therapy under near-infrared lighting, and good anti-tumor activity.

The invention provides polyamino acid which has a structure shown as a formula (I). Four polyamino acid-polyethylene glycol-polyamino acid triblock copolymers containing different side chain alkyl (H,CH3-, (CH3)2CHCH2-and (CH3)2CH-) are prepared by taking aminated polyethylene glycol as an initiating agent to initiate glycine-N-carboxylic anhydride, alanine-N-carboxylic anhydride, leucine-N-carboxylic anhydride or proline-N-carboxyl anhydride to polymerize. The invention further provides drug loading gel which comprises the polyamino acid and an anti-tumor drug loaded on the polyamino acid; as the drug loading gel provided by the invention comprises the polyamino acid, the drug loading gel has low toxicity and good temperature sensitivity.

The invention relates to a preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel, and belongs to the technical field of biological materials. The preparation method is characterized in that natural cellulose which has a unique nano-fiber three-dimensional mesh structure, a good medicine carrying property, high water content, high crystallinity, high purity andgood biocompatibility and is synthesized by microorganism fermentation is taken as a main network, and the monomer of a temperature-sensitive material, namely monor of 2-(dimethylamino)ethyl methacrylate is introduced into a nano-fiber network to be polymerized into a second network structure to form semi-interpenetrating composite gel with shorter gelation time, so that the bacterial cellulose material has temperature response and can quickly respond to water loss stimulated by external temperature, and medicines inside the hydrogel can be smoothly released from the inside of the gel to achieve a long-term slow-release effect by virtue of the network structure inside the hydrogel and the self-degradation action of the hydrogel.

The present invention is in-situ process of preparing nanometer composite material, and belongs to the field of composite material preparing technology. The in-situ preparation process of nanometer composite material includes the following steps: 1. dissolving block copolymer in 2M hydrochloric acid solution, adding precursor Fe(CO)5 slowly via stirring, adding ethyl silicate, filtering, drying the precipitant, calcining in a muffle furnace and heat treating the obtained brown powder in a vacuum furnace; and 2. treating polyisopropyl acrylamide through a cyclic 'freezing-degasing-defrosting' process , heating to react, flushing obtained dark brown powder with alcohol, filtering, drying, etc. By means of the self-assembling process of mesoporous material, nanometer composite material possessing magnetic performance and temperature stimulation responding performance and capable of being used as medicine carrier is prepared.

The invention belongs to the technical field of novel functional materials and particularly relates to a preparation method for an environment-responsive functional plastic masterbatch and an application of the environment-responsive functional plastic masterbatch. The environment-responsive functional plastic masterbatch is characterized by containing the ingredients in percentage by mass: 50% to 85% of carrier polymer, 0.1% to 15% of responsive functional component, 10% to 25% of filler and 5% to 10% of auxiliaries. The preparation method comprises the steps of mixing the carrier polymer, the responsive functional component and the auxiliaries in a high-speed mixer, then, adding the auxiliaries and the filler into the mixture, carrying out mixing in a high-speed mixer, and carrying out granulating by using a twin-screw extruder, thereby preparing the environment-responsive functional plastic masterbatch. The masterbatch is ecologically friendly and environmentally responsive and can be applied to the fields of environment-responsive functional plastic masterbatch products, multifunctional film products, plastic products for daily use, household electrical plastic products, plastic pipes, medical care, automobile interior, household fitment, and the like, and the problems, i.e., low technological content and single function of plastic masterbatch at present can be solved, so that the range of application of functional masterbatch is enlarged.

The invention relates to a porphyrin-based temperature-responsive self-healing hydrogel, a preparation method, a use method and application thereof. The preparation method comprises the following steps of: forming a Schiff base bond with a dynamic covalent bond characteristic between an aldehyde group contained in a star copolymer THPP (-MEO2MA-co-OEGMA-co-HEMA-CHO)4 and an amino group contained in branched polyethyleneimine (PEI), thereby obtaining the self-healing hydrogel. The porphyrin-based temperature-responsive self-healing hydrogel prepared by the preparation method disclosed by the invention has the advantages of injectability, photodynamic therapy, fluorescence imaging functionality, temperature responsiveness, specific recognition and enrichment of tumors and the like, and can be used as a wound dressing, a tumor drug carrier material, a stem cell carrier material, a gene vector material, fluorescence imaging, a photodynamic therapy product and the like. The structural formula of the self-healing hydrogel is shown as formula (i), wherein m is 90, n is 5-15, x is 5-10, and y is 24.

The invention discloses composite hydrogel and a preparation method and application thereof. The composite hydrogel comprises a first network and a second network, wherein the second network semi-interpenetrates the first network; the first network comprises hydrogel formed by an isopropylacrylamide monomer and nanoparticles; the second network comprises a high-molecular polymer. The composite hydrogel can be applied to the field of biology and/or medicine. The composite hydrogel has a double-network structure, and has temperature responsiveness and ultrahigh mechanical properties. The preparation of the high-elasticity hydrogel adopts cheap and readily available raw materials and a mild preparation process, so that the preparation of the hydrogel is easy for large-scale production, and the application range of the hydrogel is expanded.

The invention discloses a temperature sensitive type chelate adsorption resin and a preparation method thereof and a method for treating wastewater by using the temperature sensitive type chelate adsorption resin. The preparation method comprises the following steps that (1), porous white balls containing hanging double bonds are mixed with a swelling agent, a temperature sensitive type monomer, adopamine monomer and an initiator, and swelling is conducted; (2), the mixed system is heated in an inert gas environment, polymerization of the temperature sensitive type monomer, the dopamine monomer and double bonds in the porous white balls containing the hanging double bonds is initiated, under the action of the initiator, the dopamine monomer is subjected to self-crosslinking to form polydopamine, and the temperature sensitive type chelate adsorption resin is obtained. The resin is specially suitable for treating printing and dyeing wastewater which contains heavy metal ions and high-toxicity and nonbiodegradable naphthalene matter. The resin adsorbs and recycles the heavy metal ions and the naphthalene matter in the wastewater, the treated wastewater is discharged to reach the standards, and a feasible solution is provided for zero emission of the industrial wastewater containing the heavy metal ions and the naphthalene matter.

The invention relates to an environmental response comb-type polycondensate and a preparation method thereof. By adopting simple condensation polymerization method, copolycondensation is carried out to the polyoxyethylene with double oxygen-containing functional group or polyoxypropylene and piperazine and primary amine with long line to prepare comb-type polycondensate. The preparation method is simple and the raw materials are easy to obtain. Only solvents with low toxicity can be used as reaction medium in the reaction process, at the same time, no small molecular side product is generated during the reaction process, thus the post treatment of the product is very easy with high purity. The product obtained not only responses to temperature but also sensitively responses to pH values. At the same time, the phase inversion temperature of the polymer can be controlled by adjusting the composition of the polycondensate. As the extension to polyoxyethylene polyoxypropylene copolymer, the polycondensate not only can be applied to original applicable range of the polyoxyethylene polyoxypropylene copolymer, but also to a wider research and pracitical applying field since the polymer has richer environmental response conditions.

The invention belongs to the technical field of biomedicine, and particularly relates to temperature responsive drug-loading liposome gel and a preparation method thereof. The drug-loading liposome internally encapsulated with drugs is wrapped with glutathione modified low-acyl gellan gum, and then the glutathione modified low-acyl gellan gum modified drug-loading liposome is formed; compared with an unmodified drug-loaded liposome, the stability of the drug encapsulation efficiency is improved, and the liposome gel has certain temperature responsiveness, is in a gel state when being stored at a low temperature (4 DEG C), and is converted into a liquid state when being used at a body temperature.