Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
58results about How to "Temperature responsive" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Method for preparing chemically crosslinked photonic crystal hydrogel with adjustable color
The invention relates to a method for preparing chemically crosslinked photonic crystal hydrogel with an adjustable color. The method comprises the following steps: (1) dissolving N-isopropylacrylamide, N-hydroxyethyl acrylamide, a cross-linking agent and an emulsifier into deionized water, stirring, warming and keeping warm under the condition at 20-25 DEG C in a nitrogen condition, and then adding an initiator to continue to react for 1-4 hours, and dialyzing, so as to obtain a colloidal crystal hydrogel solution; (2) concentrating the obtained colloidal crystal hydrogel solution, standing at room temperature, adjusting the pH by adopting an NaOH solution, adding a crosslinking agent, evenly mixing, centrifuging, and standing at room temperature after taking, so as to obtain the chemically crosslinked photonic crystal hydrogel. The method is simple in process and low in cost, and the prepared photonic crystal hydrogel has thermosensibility. In addition, the obtained photonic crystal hydrogel is good in stability, and free of hydrolysis, the problem that nano hydrogel is easily decomposed because of ester hydrolysis in 2-hydroxy ethyl acrylate is solved, and the defects of the photonic crystal hydrogel in application are compensated.
Owner:DONGHUA UNIV
Polydopamine particles-doped star-shaped polymer of multi-responsive self-healing hydrogel, and self-healing hydrogel and preparation method thereof
The invention belongs to the fields of intelligent bionic materials, high-molecular materials and biomedical engineering, and concretely relates to a polydopamine particles-doped star-shaped polymer of a multi-responsive self-healing hydrogel, and the self-healing hydrogel and a preparation method thereof. In the present invention, the polydopamine nanoparticles and the star-shaped polymer SPDMAEMA-AA are prepared first; and the polydopamine nanoparticles, SPDMAEMA-AA and branched polyethyleneimine are mixed in proportion to form a crosslinked network by forming a dynamic reversible enamine bond through the acetoacetate on SPDMAEMA-AA and an amino group in the PEI molecules to obtain the hydrogel. The self-healing hydrogel material prepared by the invention has good near-infrared responsiveness, biocompatibility and high self-healing efficiency, and has potential applications in the fields of solid-state band-aids, drug slow release, cell culture, and a double-layer drive.
Owner:TONGJI UNIV
Preparation method of glucose and temperature-responsive insulin controlled release carrier
InactiveCN103865013AWide variety of sourcesGlucose responsivePharmaceutical non-active ingredientsBiocompatibility TestingTrithiocarbonic acid
The invention relates to a preparation method of a glucose and temperature-responsive insulin controlled release carrier. 1,2-diaminoethane is used as an initial raw material, is protected through di-tert-butyl dicarbonate and then is reacted with acryloyl chloride to prepare 2-aminoethyl acrylamide, and then the 2-aminoethyl acrylamide is reacted with the reaction product 4-chloroformylphenylboronic acid pinacol ester of the 4-carboxybenzeneboronic acid to prepare the monomer N-acrylamide ethyl-4-(tetramethyl-dioxaborolan)-benzamide with glucose responsiveness. The Raft polymerization of the monomer is initiated through trithiocarbonate DDMAT, and then the obtained polymer is used as a macromolecular chain transfer agent to initiate the copolymerization of the MEO2MA and the OEGMA to obtain a block copolymer material PAEB-b-P. The block copolymer has glucose and temperature responsiveness, can control the release of the carried insulin according to the concentration of the glucose in the external environment, has biodegradability, biocompatibility and bioactivity and is widely applied in the fields of medicine controlled release carriers and biological intelligent switches. The preparation method is simple and easy, the raw material can be industrially produced, and the method has great popularization and application value.
Owner:TONGJI UNIV
Hydrophobic polymer material surface hydrophilicity improving method
The invention relates to a hydrophobic polymer material surface hydrophilicity improving method. In order to solve the problem that material surface hydrophilicity is unendurable in the current blended technology, amphipathic microgel containing thermosensitive core and non thermosensitive core is taken as hydrophile modification ingredient in the invention, and surface hydrophilization modification is carried out on hydrophobic polymer material by casting method and melt blending extrusion method respectively. (1) The casting method includes: dispersion liquid of the microgel and hydrophobic polymer solution are blended, the blended even dispersion liquid is casted into a film in a mold, and solvent is removed, thus obtaining a polymer film. (2) The melt blending extrusion method includes: dry microgel and hydrophilic polymer particles are blended and then put into a rotor internal mixer to be mixed for a short time at certain temperature; the material is crushed into particles after discharging, is extruded into sheet or wire by an extruder and forms film by a hot press. The invention has the advantages of easy technique and reliable treatment effect without a complex device and can effectively improve the surface hydrophilicity of the hydrophobic polymer.
Owner:BEIJING UNIV OF CHEM TECH
Thermo-sensitive solid amine fiber material as well as preparation method and application thereof
ActiveCN104358106AWater absorption changeTemperature responsivePhysical treatmentOther chemical processesFiberMaterials science
The invention discloses a thermo-sensitive solid amine fiber material as well as a preparation method and application thereof. The thermo-sensitive solid amine fiber material is prepared by introducing amine and thermo-sensitive functional groups to the surface of base fiber through synthesis. By adopting the fiber material, the water absorption rate of the material can be changed and controlled by adjusting the change of ambient temperature, and the fiber material can be also controlled to have different water absorption rates by regulating and controlling different mole ratios of thermo-sensitive groups to amino. The fiber material can be applied to the field of intelligent special fiber products or the field of CO2 adsorption, the highest adsorption capacity of the fiber material to CO2 at 35 DEG C and 40 DEG C can be up to 3.8mmol / g, and moreover, CO2 can be completely desorbed at 70 DEG C within 30 minutes after being adsorbed by using the fiber material, so that the thermo-sensitive solid amine fiber material has the advantages of low desorption energy consumption and rapid desorption velocity.
Owner:SUN YAT SEN UNIV
Thermo-sensitive polyurethane sponge with controllable hydrophilcity-hydrophobicity conversion, and preparation method and application of thermo-sensitive polyurethane sponge
ActiveCN108341989APro-hydrophobic conversion achievedTemperature responsiveLiquid separationDouble bondOil water
The invention discloses thermo-sensitive polyurethane sponge with controllable hydrophilcity-hydrophobicity conversion, and a preparation method and application of the thermo-sensitive polyurethane sponge. The preparation method comprises the following steps: during preparation, impregnating polyurethane sponge in a chromic acid solution for coarsening to enable the surface of the polyurethane sponge to be rich in hydroxyl, then modifying the polyurethane sponge with a silane coupling agent containing double bonds, and finally grafting N-isopropylacrylamide monomers onto the polyurethane sponge through thermal-initiation polymerization so as to obtain the thermo-sensitive polyurethane sponge with controllable hydrophilcity-hydrophobicity conversion. The polyurethane sponge has temperatureresponse; the contact angle of the surface with water varies in a range of 0-150 degrees through the regulation of external temperature, so that the hydrophilcity-hydrophobicity conversion of the polyurethane sponge is realized; the oil adsorbed by the polyurethane sponge can be automatically discharged at a lower temperature without the press of external force, the oil precipitation rate is 95%,and the polyurethane sponge after the oil-water separation can be recycled after being cleaned and dried. The polyurethane sponge provided by the invention has the advantages of simple operation method, low cost, environmental friendliness and suitability for industrial production.
Owner:SOUTH CHINA UNIV OF TECH
Temperature sensitive type polyion liquid gel and preparation method thereof
The invention discloses temperature sensitive type polyion liquid gel and a preparation method thereof, relates to the field of high polymer materials, and particularly relates to temperature responsive polyion liquid gel and a preparation method thereof. The gel can be prepared by the following method: forming ion liquid by glycine of good biocompatibility and choline, and forming vinyl choline-glycine ion liquid monomer by modifying the ion liquid through acrylic acid, and then preparing the temperature sensitive type polyion liquid gel by free radical polymerization with a temperature sensitive material N-isopropyl acrylamide (NIPAAm), taking N,N-methylenebisacrylamide (MBAA) as a cross-linking agent, and potassium persulfate as an initiator. The gel is applied to damage-free desorption of cells.
Owner:TIANJIN POLYTECHNIC UNIV
Preparation method of ethyl cellulose nano micelle with UCST (upper critical solution temperature)
InactiveCN104877081AWide variety of sourcesTemperature responsiveUpper critical solution temperatureAtom-transfer radical-polymerization
Owner:TONGJI UNIV
Preparation method of thermo-sensitive chitosan polymer connected with sugar molecules
InactiveCN104387537AWide variety of sourcesThe synthesis method is simpleClick chemistryGlycol synthesis
The invention belongs to the field of biological materials and nano-materials and particularly relates to a preparation method of a thermo-sensitive chitosan polymer connected with sugar molecules. The method comprises the specific steps of initiating atom transfer radical polymerization (ATRP) of 2-(2-methoxyethoxy) ethylmethacrylate (MEO2MA) and oligo(ethylene glycol) methacrylate (OEGMA) by taking a chitosan bromide (CS-Br) as a macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-Br; initiating the ATRP of hydroxyethyl methacrylate (HEMA) by taking the CS-g-P(MEO2MA-co-OEGMA)-Br as the macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-poly(2-hydroxyethyl methacrylate (PHEMA); performing esterification reaction and click chemistry to obtain a thermo-sensitive copolymer of which chitosan serves as a main chain and galactose is grafted. The polymer has biocompatibility, biodegradability, thermo-sensibility and liver targeting, and the polymer in a water solution can be self-assembled to form micelle, and has a wide application prospect in the fields of medicine controlled release, targeted therapy, biosensors and the like. The preparation method is simple and easy to operate, and has a great popularization and application value. Raw materials can be industrially produced.
Owner:TONGJI UNIV
Method for preparing hydrogel having magnetism and temperature synergistic stimulus-responding
ActiveCN109295716ASimple processIncrease productionFibre typesMonocomponent synthetic polymer artificial filamentNanofiberPorosity
The invention relates to a preparation method for preparing hydrogel having magnetism and temperature synergistic stimulus-responding. The method comprises the following steps: firstly preparing Fe3O4magnetic nanoparticles by a coprecipitation method, and adding Fe3O4 magnetic nanoparticles into a PU solution, preparing the PU / Fe3O4 magnetic composite nanofibers by a thermally induced phase separation method, and finally, grafting N-isopropylacrylamide to the PU fiber membrane by ultraviolet radiation grafted polymerization. The large specific surface area and high porosity of the PU nanofibers are used, the hydrogel is beneficial to the diffusion of water molecules during swelling and shrinkage, and the response rate of the hydrogel is greatly improved. The prepared PU-g-PNIPAm / Fe3O4 composite nanofiber hydrogel has dual magnetism and temperature responsiveness by using the temperature sensitivity of N-isopropylacrylamide and the magnetic properties of Fe3O4.
Owner:晋江瑞碧科技有限公司 +1
Poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and preparation method thereof
InactiveCN101880398APH responsiveIncreased equilibrium swelling ratePharmaceutical non-active ingredientsProsthesis(Hydroxyethyl)methacrylateEthylene Homopolymers
The invention provides a poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the step of carrying out copolymerization synthesis on poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the free radical of hydroxy propyl cellulose-g-acrylic acid, wherein the mass percent between the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the hydroxy propyl cellulose-g-acrylic acid is 10-90%: 90-10%. The obtained hydrogel has the characteristics ofthe two homopolymers and is sensitive for the temperature and the pH; and furthermore, the poly (L-glutamic acid) part in the hydrogel can be biodegradable, so that the material can not be accumulated in the body, and the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel can be taken as a novel intelligent drug release carrier.
Owner:NORTHEAST NORMAL UNIVERSITY
Thermo-responsive polypeptoid containing oligomeric polyethylene glycol in side chain and preparation method of polypeptoid
The invention discloses a thermo-responsive polypeptoid containing oligomeric polyethylene glycol (OEG) in a side chain and a preparation method of the polypeptoid. A click chemical reaction under ultraviolet light is carried out on a polypeptoid containing acetylenic bonds in a side chain with methoxy oligomeric ethylene glycol mercaptan (OEGX-SH), so that the target thermo-responsive polypeptoidis obtained. The thermo-responsive polypeptoid disclosed by the invention is simple in synthetic route, low in cost, high in purity, high in product yield, stable in property, simple in structure andeasy in regulate and control; the temperature responsiveness is easy to regulate and control; and the thermo-responsive polypeptoid is an excellent thermo-responsive polypeptoid material, and has a wide potential application value and research value.
Owner:QINGDAO UNIV OF SCI & TECH
Polyamino acid, preparation method thereof and drug-loaded gel
InactiveCN108276573ATemperature responsiveGood biocompatibilityOrganic active ingredientsAerosol deliverySide chainTert-leucine
The invention provides polyamino acid, which has a structure shown in a formula (I). Aminated methoxypolyethylene glycol is used as an initiator for initiating glycine-N-carboxyl anhydride, alanine-N-carboxyl anhydride, leucine-N-carboxyl anhydride or valine-N-carboxyl anhydride for polymerization, so that four polyamino acid-polyethylene glycol-polyamino acid triblock copolymers containing different side chain alkyl groups (H, CH3<->, (CH3)2CHCH2<->and (CH3)2CH<->) can be prepared. The application also provides drug-loaded gel which is prepared from the polyamino acid and an antitumor drug loaded on the polyamino acid. The drug-loaded gel provided by the application is prepared from the polyamino acid, thus having low toxicity and good temperature sensibility.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Method for preparing calcium alginate microspheres with temperature response performance
ActiveCN101962464ASimple and safe operationTemperature responsivePharmaceutical non-active ingredientsMicroballoon preparationTemperature responseMicrosphere
The invention discloses a method for preparing calcium alginate microspheres with temperature response performance, which comprises the following steps of: fully dissolving selected amount of N-vinylcaprolactam and the like and sodium alginate in water, preparing into aqueous solution, adding an initiator, uniformly mixing for deoxidation, and performing stirring reaction at constant temperature for 3 to 6 hours; cooling the reaction liquid obtained in the last step to room temperature, slowly adding into an oil phase in which an emulsifier 1 is dissolved for emulsification, adding into aqueous solution with an emulsifier 2 for emulsification, dripping a cross-linker with high-speed stirring, stirring, and curing; and precipitating the emulsion obtained in the last step by using absolute ethyl alcohol, performing centrifugal separation, washing with absolute ethyl alcohol and distilled water respectively, and performing freeze drying to obtain the finished product. The calcium alginate microspheres have certain temperature response performance, and the response temperature is near the physiological temperature; and the calcium alginate microspheres have good biocompatibility and biodegradability, and have wide application prospect in the field of biomedicines, particularly in the aspect of control release of medicines.
Owner:QINGDAO UNIV
Nano medicine delivery system for photo-thermal chemotherapy combined therapy and preparation method
InactiveCN108478529AWide variety of sourcesThe synthesis method is simpleOrganic active ingredientsEnergy modified materialsMethacrylamideDoxorubicin
The invention provides a nano medicine delivery system for photo-thermal chemotherapy combined therapy and a preparation method. The nano medicine delivery system is medicine carrying micelle, whereinthe medicine carrying micelle is prepared by enabling poly-propylene sulfide-b-poly(N-isopropyl acrylamide-co-N,N-dimethacrylamide) of formula (I) as shown in the specification to polymerize by self,and by coating doxorubicin (DOX) and indocyanine green (IGG) in micelle. The nano medicine delivery system is characterized in that under radiation of near-infrared light of 808nm, because of photo-thermal effects of the indocyanine green, a temperature can be increased, a hydrophilic layer on the surface of the micelle can be turned into a hydrophobic layer, and the uptake of tumor cells upon the medicine carrying micelle can be improved; meanwhile, the medicine carrying micelle can be oxidized by singlet oxygen generated from the indocyanine green in lighting, and thus medicine release canbe promoted. The nano medicine delivery system has the characteristics of dual responsiveness, combined therapy under near-infrared lighting, and good anti-tumor activity.
Owner:CHONGQING UNIV
Polyamino acid, a preparation method, and drug loading gel
InactiveCN108003342AGood biocompatibilityTemperature responsiveOrganic active ingredientsAerosol deliverySide chainChemistry
The invention provides polyamino acid which has a structure shown as a formula (I). Four polyamino acid-polyethylene glycol-polyamino acid triblock copolymers containing different side chain alkyl (H,CH3-, (CH3)2CHCH2-and (CH3)2CH-) are prepared by taking aminated polyethylene glycol as an initiating agent to initiate glycine-N-carboxylic anhydride, alanine-N-carboxylic anhydride, leucine-N-carboxylic anhydride or proline-N-carboxyl anhydride to polymerize. The invention further provides drug loading gel which comprises the polyamino acid and an anti-tumor drug loaded on the polyamino acid; as the drug loading gel provided by the invention comprises the polyamino acid, the drug loading gel has low toxicity and good temperature sensitivity.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel
InactiveCN108003358ATemperature responsiveSmooth releaseAerosol deliveryOintment deliveryMethacrylateTemperature response
The invention relates to a preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel, and belongs to the technical field of biological materials. The preparation method is characterized in that natural cellulose which has a unique nano-fiber three-dimensional mesh structure, a good medicine carrying property, high water content, high crystallinity, high purity andgood biocompatibility and is synthesized by microorganism fermentation is taken as a main network, and the monomer of a temperature-sensitive material, namely monor of 2-(dimethylamino)ethyl methacrylate is introduced into a nano-fiber network to be polymerized into a second network structure to form semi-interpenetrating composite gel with shorter gelation time, so that the bacterial cellulose material has temperature response and can quickly respond to water loss stimulated by external temperature, and medicines inside the hydrogel can be smoothly released from the inside of the gel to achieve a long-term slow-release effect by virtue of the network structure inside the hydrogel and the self-degradation action of the hydrogel.
Owner:吴刚
Process for preparing original position of nanometer laminated composite material
InactiveCN101081302AHigh drug loadingIncrease loading capacityCatalyst carriersInorganic non-active ingredientsSilicic acidMesoporous material
The present invention is in-situ process of preparing nanometer composite material, and belongs to the field of composite material preparing technology. The in-situ preparation process of nanometer composite material includes the following steps: 1. dissolving block copolymer in 2M hydrochloric acid solution, adding precursor Fe(CO)5 slowly via stirring, adding ethyl silicate, filtering, drying the precipitant, calcining in a muffle furnace and heat treating the obtained brown powder in a vacuum furnace; and 2. treating polyisopropyl acrylamide through a cyclic 'freezing-degasing-defrosting' process , heating to react, flushing obtained dark brown powder with alcohol, filtering, drying, etc. By means of the self-assembling process of mesoporous material, nanometer composite material possessing magnetic performance and temperature stimulation responding performance and capable of being used as medicine carrier is prepared.
Owner:SHANGHAI JIAO TONG UNIV
Preparation method for environment-responsive functional plastic masterbatch
The invention belongs to the technical field of novel functional materials and particularly relates to a preparation method for an environment-responsive functional plastic masterbatch and an application of the environment-responsive functional plastic masterbatch. The environment-responsive functional plastic masterbatch is characterized by containing the ingredients in percentage by mass: 50% to 85% of carrier polymer, 0.1% to 15% of responsive functional component, 10% to 25% of filler and 5% to 10% of auxiliaries. The preparation method comprises the steps of mixing the carrier polymer, the responsive functional component and the auxiliaries in a high-speed mixer, then, adding the auxiliaries and the filler into the mixture, carrying out mixing in a high-speed mixer, and carrying out granulating by using a twin-screw extruder, thereby preparing the environment-responsive functional plastic masterbatch. The masterbatch is ecologically friendly and environmentally responsive and can be applied to the fields of environment-responsive functional plastic masterbatch products, multifunctional film products, plastic products for daily use, household electrical plastic products, plastic pipes, medical care, automobile interior, household fitment, and the like, and the problems, i.e., low technological content and single function of plastic masterbatch at present can be solved, so that the range of application of functional masterbatch is enlarged.
Owner:无锡麦克罗新材料科技有限公司
Preparation method of temperature-responsive Janus nanofiber dressing
ActiveCN112853739ATemperature responsiveReversible thickness adjustmentFibre typesAbsorbent padsFiberPolymer science
The invention relates to the field of medical materials, and discloses a preparation method of a temperature-responsive Janus nanofiber dressing. The method comprises the following steps of (1) preparing a temperature-sensitive polymer; (2) preparing the temperature-responsive Janus nanofiber dressing: sequentially electrospinning a spinning solution containing the temperature-sensitive polymer and a polyurethane spinning solution on a cotton fabric through an electrostatic spinning technology to prepare the Janus nanofiber dressing with a three-layer structure, wherein the bottom layer is hydrophilic layer cotton, the middle layer is temperature-sensitive nanofiber, and the upper layer is hydrophobic layer polyurethane nanofiber; and (3) performing cross-linking treatment: carrying out hot-pressing cross-linking on the Janus nanofiber dressing to obtain the finished dressing. The prepared Janus nanofiber dressing has temperature responsiveness, and the thickness of the hydrophobic part of the Janus nanofiber can be reversibly switched through wettability transformation of the temperature-sensitive layer, so that the liquid transportation direction is controlled, and intelligent body fluid management is realized.
Owner:ZHEJIANG SCI-TECH UNIV
Preparation method for zinc oxide nanoflower/nanogold composite based temperature sensitive imprinted polymer
InactiveCN110092867AIncreased electron transport capacitySimple preparation processOther chemical processesElectrolytic organic material coatingPolymer modifiedTemperature sensitive
The invention discloses a preparation method for a zinc oxide nanoflower / nanogold composite based temperature sensitive imprinted polymer. The method includes the following steps: preparing a zinc oxide nanoflower, and preparing a zinc oxide nanoflower modified electrode; taking the zinc oxide nanoflower modified electrode as a working electrode, taking a saturated calomel electrode as a referenceelectrode, and taking a platinum filament as a counter electrode so that a zinc oxide nanoflower / nanogold composite modified electrode can be obtained; and self-assembling a bromine-containing compound on a sulfydryl sealing end on the surface of the zinc oxide nanoflower / nanogold composite modified electrode, forming a bromine-containing compound modified zinc oxide / nanogold composite modified electrode, preparing a polymer modified zinc oxide nanoflower / nanogold composite modified electrode to take out, removing template molecules in the polymer, and performing natural air drying after thewashing of ultrapure water so that a zinc oxide nanoflower / nanogold composite based temperature sensitive imprinted polymer can be obtained.
Owner:LIAONING NORMAL UNIVERSITY
Porphyrin-based temperature-responsive self-healing hydrogel, preparation method, use method and application thereof
The invention relates to a porphyrin-based temperature-responsive self-healing hydrogel, a preparation method, a use method and application thereof. The preparation method comprises the following steps of: forming a Schiff base bond with a dynamic covalent bond characteristic between an aldehyde group contained in a star copolymer THPP (-MEO2MA-co-OEGMA-co-HEMA-CHO)4 and an amino group contained in branched polyethyleneimine (PEI), thereby obtaining the self-healing hydrogel. The porphyrin-based temperature-responsive self-healing hydrogel prepared by the preparation method disclosed by the invention has the advantages of injectability, photodynamic therapy, fluorescence imaging functionality, temperature responsiveness, specific recognition and enrichment of tumors and the like, and can be used as a wound dressing, a tumor drug carrier material, a stem cell carrier material, a gene vector material, fluorescence imaging, a photodynamic therapy product and the like. The structural formula of the self-healing hydrogel is shown as formula (i), wherein m is 90, n is 5-15, x is 5-10, and y is 24.
Owner:SHANGHAI TENTH PEOPLES HOSPITAL
Composite hydrogel and preparation method and application thereof
PendingCN112646089ATemperature responsiveImprove mechanical propertiesAerosol deliveryOintment deliveryPolymer scienceDouble network
The invention discloses composite hydrogel and a preparation method and application thereof. The composite hydrogel comprises a first network and a second network, wherein the second network semi-interpenetrates the first network; the first network comprises hydrogel formed by an isopropylacrylamide monomer and nanoparticles; the second network comprises a high-molecular polymer. The composite hydrogel can be applied to the field of biology and / or medicine. The composite hydrogel has a double-network structure, and has temperature responsiveness and ultrahigh mechanical properties. The preparation of the high-elasticity hydrogel adopts cheap and readily available raw materials and a mild preparation process, so that the preparation of the hydrogel is easy for large-scale production, and the application range of the hydrogel is expanded.
Owner:GUANGDONG PROV MEDICAL INSTR INST
Temperature sensitive type chelate adsorption resin and preparation method thereof and method for treating wastewater by using temperature sensitive type chelate adsorption resin
ActiveCN110314670AEnhanced π-π interactionsImprove processing efficiencyOther chemical processesWater contaminantsDouble bondDyeing wastewater
The invention discloses a temperature sensitive type chelate adsorption resin and a preparation method thereof and a method for treating wastewater by using the temperature sensitive type chelate adsorption resin. The preparation method comprises the following steps that (1), porous white balls containing hanging double bonds are mixed with a swelling agent, a temperature sensitive type monomer, adopamine monomer and an initiator, and swelling is conducted; (2), the mixed system is heated in an inert gas environment, polymerization of the temperature sensitive type monomer, the dopamine monomer and double bonds in the porous white balls containing the hanging double bonds is initiated, under the action of the initiator, the dopamine monomer is subjected to self-crosslinking to form polydopamine, and the temperature sensitive type chelate adsorption resin is obtained. The resin is specially suitable for treating printing and dyeing wastewater which contains heavy metal ions and high-toxicity and nonbiodegradable naphthalene matter. The resin adsorbs and recycles the heavy metal ions and the naphthalene matter in the wastewater, the treated wastewater is discharged to reach the standards, and a feasible solution is provided for zero emission of the industrial wastewater containing the heavy metal ions and the naphthalene matter.
Owner:WANHUA CHEM GRP CO LTD +1
Copolymer drug-loaded micelle system with temperature and oxidation double responsive properties and preparation method of micelle system
InactiveCN107189024AWide variety of sourcesTemperature responsivePharmaceutical non-active ingredientsEmulsion deliveryPolymer scienceIsopropyl
The invention provides a preparation method of a polymer micelle with temperature and oxidation double responsive properties. The polymer micelle with the temperature and oxidation double responsive properties is prepared through self aggregation of polycyclic thiopropylene-b-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) shown in the formula (1) and characterized by having the temperature responsive property and the oxidation responsive property at the same time. The micelle has the advantages of being sensitive to low-concentration reactive oxygen, adjustable in the lowest critical temperature and stable. The formula can be seen from the description.
Owner:CHONGQING UNIV
A water-soluble polymer with multiple stimuli responsiveness and its preparation method
Owner:NANKAI UNIV
Fluorescent and phosphorescent double luminescent material with switching effect and preparation method thereof
ActiveCN110041905AHigh strengthProtectLuminescent compositionsOxidation-Reduction AgentRoom temperature
The invention belongs to the field of supramolecular luminescent materials, and more specifically relates to a fluorescent and phosphorescent double luminescent material with switching effect and a preparation method thereof. The double luminescent material is prepared from a supramolecular gel formed by a gel factor and a luminescent molecule fixed in the supramolecular gel. The gel factor is a micromolecular gel factor containing a disulfide bond, and the luminescent molecule is a fluorescent and room temperature phosphorescent double luminescent molecule. The supramolecular material has redox responsiveness. When the double luminescent material is used, and the disulfide bond of the gel factor is reduced to sulfydryl, the supramolecular gel is destroyed, and fluorescence and phosphorescence are turned off at the same time. When the sulfydryl in the gel factor in the double luminescent material is oxidized to disulfide bond, the supramolecular gel is re-formed, and fluorescence and phosphorescence are turned on to realize redox responsiveness of the double luminescent material.
Owner:HUAZHONG UNIV OF SCI & TECH
Environmentally responsive comb type polycondensate and preparation thereof
The invention relates to an environmental response comb-type polycondensate and a preparation method thereof. By adopting simple condensation polymerization method, copolycondensation is carried out to the polyoxyethylene with double oxygen-containing functional group or polyoxypropylene and piperazine and primary amine with long line to prepare comb-type polycondensate. The preparation method is simple and the raw materials are easy to obtain. Only solvents with low toxicity can be used as reaction medium in the reaction process, at the same time, no small molecular side product is generated during the reaction process, thus the post treatment of the product is very easy with high purity. The product obtained not only responses to temperature but also sensitively responses to pH values. At the same time, the phase inversion temperature of the polymer can be controlled by adjusting the composition of the polycondensate. As the extension to polyoxyethylene polyoxypropylene copolymer, the polycondensate not only can be applied to original applicable range of the polyoxyethylene polyoxypropylene copolymer, but also to a wider research and pracitical applying field since the polymer has richer environmental response conditions.
Owner:SHANGHAI JIAO TONG UNIV
Temperature-responsive drug-loaded liposome gel and preparation method thereof
ActiveCN113081966AImprove stabilityTemperature responsiveAerosol deliveryOintment deliveryGellan gumLiquid state
The invention belongs to the technical field of biomedicine, and particularly relates to temperature responsive drug-loading liposome gel and a preparation method thereof. The drug-loading liposome internally encapsulated with drugs is wrapped with glutathione modified low-acyl gellan gum, and then the glutathione modified low-acyl gellan gum modified drug-loading liposome is formed; compared with an unmodified drug-loaded liposome, the stability of the drug encapsulation efficiency is improved, and the liposome gel has certain temperature responsiveness, is in a gel state when being stored at a low temperature (4 DEG C), and is converted into a liquid state when being used at a body temperature.
Owner:CHANGZHOU UNIV
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com