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Preparation method of temperature-responsive Janus nanofiber dressing

A nanofiber, temperature-responsive technology, applied in the direction of fiber type, fiber treatment, conjugated synthetic polymer artificial filament, etc., can solve the problems of destroying the humidity balance of the wound healing microenvironment, unfavorable wound healing, etc., and achieve the effect of improving control

Active Publication Date: 2021-05-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, wound dressings with Janus structure will continuously pump out wound exudate, which will disrupt the humidity balance of the wound healing microenvironment, which is extremely detrimental to wound healing

Method used

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  • Preparation method of temperature-responsive Janus nanofiber dressing
  • Preparation method of temperature-responsive Janus nanofiber dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Add 60% of monomer acrylamide, 20% of acrylonitrile, and 20% of N-methylolacrylamide (total concentration: 1mM) into a round-bottomed flask by molar ratio, and add 1% of monomer molar ratio Add azobisisobutyronitrile into dimethyl sulfoxide solution, deoxygenate with nitrogen, and react at 55°C. After the reaction was completed, the solution was cooled to room temperature, then dialyzed in deionized water for 40 h, and freeze-dried to obtain the target product for future use.

[0029] (2) Use N,N-dimethylformamide as a solvent to prepare 15wt% thermosensitive polymer solution and 15wt% polyurethane solution respectively, and then mix the above two solutions into a uniform spinning solution, wherein the polyurethane solution The mass ratio to the temperature-sensitive solution is 1:2. The temperature-sensitive layer was obtained by electrospinning the temperature-sensitive / polyurethane blend solution on cotton fabric by electrospinning. The spinning parameters were:...

Embodiment 2

[0032] (1) Add monomer acrylamide 60%, acrylonitrile 20%, N-methylol acrylamide 20% (total concentration 0.5mM) into the round bottom flask by molar ratio, and add 1% of monomer molar ratio Add azobisisobutyronitrile into dimethyl sulfoxide solution, deoxygenate with nitrogen, and react at 55°C. After the reaction was completed, the solution was cooled to room temperature, then dialyzed in deionized water for 40 h, and freeze-dried to obtain the target product for future use.

[0033](2) Use N,N-dimethylformamide as a solvent to prepare 18wt% thermosensitive polymer solution and 16wt% polyurethane solution respectively, and then mix the above two solutions into a uniform spinning solution, wherein the polyurethane solution The mass ratio to the temperature-sensitive solution is 1:3. The temperature-sensitive layer was obtained by electrospinning the temperature-sensitive / polyurethane blend solution on cotton fabric by electrospinning. The spinning parameters were: spinning sp...

Embodiment 3

[0036] (1) Add 60% of monomer acrylamide, 20% of acrylonitrile, and 20% of N-methylolacrylamide (total concentration is 2mM) into a round bottom flask by molar ratio, and add 1% of monomer molar ratio Add azobisisobutyronitrile into dimethyl sulfoxide solution, deoxygenate with nitrogen, and react at 55°C. After the reaction was completed, the solution was cooled to room temperature, then dialyzed in deionized water for 40 h, and freeze-dried to obtain the target product for future use.

[0037] (2) Use N,N-dimethylformamide as a solvent to prepare 18wt% thermosensitive polymer solution and 15wt% polyurethane solution respectively, and then mix the above two solutions into a uniform spinning solution, wherein the polyurethane solution The mass ratio to the temperature-sensitive solution is 1:2. The temperature-sensitive layer was obtained by electrospinning the temperature-sensitive / polyurethane blend solution on cotton fabrics by electrospinning. The spinning parameters were...

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Abstract

The invention relates to the field of medical materials, and discloses a preparation method of a temperature-responsive Janus nanofiber dressing. The method comprises the following steps of (1) preparing a temperature-sensitive polymer; (2) preparing the temperature-responsive Janus nanofiber dressing: sequentially electrospinning a spinning solution containing the temperature-sensitive polymer and a polyurethane spinning solution on a cotton fabric through an electrostatic spinning technology to prepare the Janus nanofiber dressing with a three-layer structure, wherein the bottom layer is hydrophilic layer cotton, the middle layer is temperature-sensitive nanofiber, and the upper layer is hydrophobic layer polyurethane nanofiber; and (3) performing cross-linking treatment: carrying out hot-pressing cross-linking on the Janus nanofiber dressing to obtain the finished dressing. The prepared Janus nanofiber dressing has temperature responsiveness, and the thickness of the hydrophobic part of the Janus nanofiber can be reversibly switched through wettability transformation of the temperature-sensitive layer, so that the liquid transportation direction is controlled, and intelligent body fluid management is realized.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a temperature-responsive Janus nanofiber dressing. Background technique [0002] In recent years, Janus membrane materials have attracted more and more attention. In a broad sense, the two sides of Janus membrane materials have different properties, such as composition, morphology, wettability, surface charge, etc., which can have unique transport behaviors through the synergistic effect of opposite properties on both sides, such as one-way oil / water separation, switchable ion transport and mist collection, etc. The Janus structure has a unique one-way transport performance. The introduction of the Janus structure into the wound dressing can lead to the one-way export of wound exudate, thereby accelerating wound healing, which provides a new research strategy for the design of wound dressings. However, the wound dressing with Janus structure will contin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M11/38D06M11/79D01F8/10D01F8/16A61L15/24A61L15/26A61L15/42D06M101/38
CPCD06M11/38D06M11/79D01F8/10D01F8/16A61L15/42A61L15/24A61L15/26A61L2300/412D06M2101/38C08L33/26C08L75/04
Inventor 邱智晔刘磊吴金丹
Owner ZHEJIANG SCI-TECH UNIV
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