A water-soluble polymer with multiple stimuli responsiveness and its preparation method

A water-soluble polymer, multi-stimulation technology, applied in the field of water-soluble polymers and their preparation, can solve the uncontrollability of the synthesis process, the inability of the polymer to meet the multiple properties of biological macromolecules, the molecular weight and molecular weight of end-group functional macromolecules Problems such as wide distribution to achieve the effect of wide applicability

Active Publication Date: 2017-03-29
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the synthesis of protein-reactive polymers is based on free radical synthesis. Due to the uncontrollability of the synthesis process, the molecular weight and molecular weight distribution of the synthesized terminal functional polymers are relatively wide.
[0003] Due to its neutrality, non-toxicity, and good biocompatibility, PGE with end group functionalization is the most widely used for modifying the surface of biomacromolecules such as proteins and their assemblies, nanoparticles, and various macroscopic materials. , but with the development of the times, single-functional polymers are far from meeting the demand for multiple properties of biomacromolecules

Method used

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  • A water-soluble polymer with multiple stimuli responsiveness and its preparation method
  • A water-soluble polymer with multiple stimuli responsiveness and its preparation method
  • A water-soluble polymer with multiple stimuli responsiveness and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A water-soluble polymer with multiple stimuli responsiveness is a NIPAM homopolymer whose end group is N-hydroxysuccinimide (NHS), and its structural formula is:

[0033]

[0034] In the formula: the polymerization degree n of the monomer is 48.

[0035] Described end group is the preparation method of the NIPAM homopolymer of N-hydroxysuccinimide (NHS), and step is as follows

[0036] 1) Synthesis of NIPAM homopolymer whose end group is dodecyl trithiocarbonate

[0037] Dissolve 1.2796 g of polymer monomer N-isopropylacrylamide (NIPAM) in 4.5 mL of distilled dioxane, chain transfer agent dodecyl trithiocarbonate-2-methyl- Propionic acid (DMP) 66.59mg dissolved in 0.5mL redistilled dioxane and initiator azobisisobutyronitrile (AIBN) 10mg dissolved in 0.2mL redistilled dioxane, under nitrogen protection Mix and add to a 25mL eggplant-shaped bottle, freeze-vacuum-thaw three times, put it in a 70°C oil bath for 17 hours, the product is precipitated with ether, and aft...

Embodiment 2

[0045]A water-soluble polymer with multiple stimuli responsiveness, the molar content of 4VP is 9.69% 4VP with NHS end group, NIPAM copolymer, its structural formula is:

[0046]

[0047] In the formula: the polymerization degree n of the monomer is 42.

[0048] The molar content of described 4VP is that the end group of 9.69% is 4VP of NHS, the preparation method of NIPAM copolymer, the steps are as follows:

[0049] 1) Synthesis of 4VP, NIPAM copolymer whose end group is dodecyl trithiocarbonate

[0050] Dissolve polymer monomer NIPAM 1.1689g, 4VP 0.1198g in 5mL distilled dioxane, chain transfer agent DMP 66.59mg in 0.5mL distilled dioxane and neutralize initiator azo Dissolve 10 mg of diisobutyronitrile (AIBN) in 0.2 mL of redistilled dioxane, mix and add it into a 25 mL eggplant-shaped bottle under nitrogen protection, freeze-vacuum-thaw three times, and place at 70 The reaction was carried out in an oil bath at ℃ for 17 hours, and the product was precipitated with di...

Embodiment 3

[0056] A water-soluble polymer with multiple stimuli responsiveness, the molar content of 4VP is 20.33% 4VP with NHS end group, NIPAM copolymer, its structural formula is:

[0057]

[0058] In the formula: the polymerization degree n of the monomer is 37.

[0059] Described 4VP molar content is 20.33% end group is 4VP of NHS, the preparation method of NIPAM copolymer, the steps are as follows:

[0060] 1) Synthesis of 4VP, NIPAM copolymer whose end group is dodecyl trithiocarbonate

[0061] Dissolve polymer monomer NIPAM 1.0381g, 4VP 0.24147g in 5mL distilled dioxane, chain transfer agent DMP 66.59mg in 0.5mL distilled dioxane and neutralize initiator azo Dissolve 10 mg of diisobutyronitrile (AIBN) in 0.2 mL of re-distilled dioxane, mix and add it into a 25 mL eggplant-shaped bottle under nitrogen protection, freeze-vacuum-thaw three times, and place in 70°C oil Reaction in the bath for 17 hours, the product was precipitated with ether, and after vacuum drying, the termin...

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Abstract

Disclosed is a water-soluble polymer with multi-stimulative-responsibility. The general molecular formula of the water-soluble polymer is as follows, wherein R and Q are polymer monomers, n which refers to the degree of polymerization of the monomers is 10 to 150, and each polymer monomer is one or an any proportion of mixture of two of N-Isopropylacrylamide, 4-Vinylpyridine and 4-(1, 6-dioxide-2, 5-diaza-7-oxamoyl) phenylboronic acid pinacol ester. According to the water-soluble polymer with the multi-stimulative-responsibility and a preparation method thereof, the regulation on the molecular structure of the polymer can be implemented and the accurate control on the molecular weight and the distribution of the polymer can be implemented due to the water-soluble polymer; the applicability range of the monomers is wide and the polymer with the biological responsibility or the multi-stimulative-responsibility can be composed by the preparation method, wherein the multi-stimulative-responsibility comprises the temperature responsibility, the pH (Potential Of Hydrogen) responsibility, the sugar responsibility and the like; the modification on biomacromolecules such as protein can be implemented and functional materials such as biological drugs can be built through the composed end group functional polymer.

Description

technical field [0001] The invention belongs to polymer synthesis technology, in particular to a water-soluble polymer with multiple stimuli responsiveness and a preparation method thereof. Background technique [0002] The multi-responsive nano-drug carrier can respond to two or more stimuli. This response may occur simultaneously at the lesion site, or occur in an orderly manner during the delivery of drugs by the nano-carrier, so it has multiple responses. Sexual nano-drug carriers may have better controllable effects during drug delivery and release. Temperature-responsive, pH-responsive, sugar-responsive, redox-responsive and other stimuli-responsive protein-responsive polymers, due to their potential in the loading of protein drugs and the modification of biological macromolecules such as proteins Therefore, it has aroused great attention in current biotechnology. It has been proven that macromolecules attached to proteins through covalent bonds can significantly red...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/54C08F2/38C08F8/00C08F8/30C08F220/54C08F226/06C08F130/06
Inventor 张珍坤张川刘帅宇郑春雄史林启
Owner NANKAI UNIV
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