Temperature-responsive drug-loaded liposome gel and preparation method thereof

A liposome gel, temperature-responsive technology, applied in the field of biomedicine, can solve problems such as poor stability and inability to withstand mechanical stress, and achieve the effect of improving stability

Active Publication Date: 2021-07-09
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Membranes such as liposomes cannot withstand mechanical stress and are less stable

Method used

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  • Temperature-responsive drug-loaded liposome gel and preparation method thereof
  • Temperature-responsive drug-loaded liposome gel and preparation method thereof
  • Temperature-responsive drug-loaded liposome gel and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0028] A temperature-responsive drug-loaded liposome gel and a preparation method thereof, comprising the following steps:

[0029] (1) Dissolve the medicine of prescribed quantity in 5% glucose solution, and control drug concentration to be 1-5mg / mL; Then add lipid film, and shake in shaker more than 30min, make lipid film redissolve; Sonicate in a water bath for more than 10 minutes to make the solution transparent; use an ultrasonic cell pulverizer to sonicate the obtained transparent solution for 30 s, intermittently for 30 s, and repeat 6 ± 3 times to form a liposome dispersion loaded with galantamine hydrobromide;

[0030] (2) The prepared glutathione-modified low-acyl gellan gum solution (mass concentration 0.05%) and the drug-loaded liposome (DOTAP phospholipid: cholesterol: galantamine hydrobromide) prepared in step (1) After the solution with a mass ratio of 3.8:2.1:4) was evenly mixed, it was incubated at 37°C for about 40 minutes, and then the temperature-responsiv...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to temperature responsive drug-loading liposome gel and a preparation method thereof. The drug-loading liposome internally encapsulated with drugs is wrapped with glutathione modified low-acyl gellan gum, and then the glutathione modified low-acyl gellan gum modified drug-loading liposome is formed; compared with an unmodified drug-loaded liposome, the stability of the drug encapsulation efficiency is improved, and the liposome gel has certain temperature responsiveness, is in a gel state when being stored at a low temperature (4 DEG C), and is converted into a liquid state when being used at a body temperature.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a temperature-responsive drug-loaded liposome gel and a preparation method thereof. Background technique [0002] In the field of nanomedicine, phospholipid-based systems (i.e., liposomes) are undoubtedly promising due to a series of recognized advantages such as good biocompatibility and biodegradability, low antigenicity, and unique delivery capabilities of hydrophilic and hydrophobic compounds. Currently the most studied drug delivery platform. Due to these characteristics, liposomes were proposed in the 1970s as attractive drug delivery vehicles. Despite these advantages, studies conducted over the years have highlighted some disadvantages of liposomes as drug delivery systems, mainly related to physical and chemical stability issues. Membranes such as liposomes cannot withstand mechanical stress and are less stable. . Contents of the invention [0003] In order to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/06A61K47/42A61K47/36A61K31/55
CPCA61K9/1271A61K9/1277A61K9/06A61K47/42A61K47/36A61K31/55Y02A50/30
Inventor 周舒文郑鑫萌陶思曼徐以洋陈珺王建浩邱琳崔朋飞王程
Owner CHANGZHOU UNIV
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