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Polydopamine particles-doped star-shaped polymer of multi-responsive self-healing hydrogel, and self-healing hydrogel and preparation method thereof

A technology of polydopamine particles and star-shaped polymers, which is applied in the field of intelligent bionic materials, can solve problems such as destruction, hydrogen bond formation, and DMAEMA solubility reduction, and achieve the effects of wide sources, good bioadhesion, and high healing efficiency

Active Publication Date: 2018-11-30
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the temperature of the system changes, it can cause the formation and destruction of hydrogen bonds, so that the solubility of DMAEMA in water decreases with the increase of temperature

Method used

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  • Polydopamine particles-doped star-shaped polymer of multi-responsive self-healing hydrogel, and self-healing hydrogel and preparation method thereof
  • Polydopamine particles-doped star-shaped polymer of multi-responsive self-healing hydrogel, and self-healing hydrogel and preparation method thereof
  • Polydopamine particles-doped star-shaped polymer of multi-responsive self-healing hydrogel, and self-healing hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 1.36g (0.01mol) of dry pentaerythritol, 50.00mL of dry tetrahydrofuran, and 8.22mL of dry triethylamine into the dry reaction flask, and dissolve 7.42mL (0.06mol) of 2-bromoisobutyryl bromide in 10.00 mL of tetrahydrofuran was slowly added dropwise to the flask; after sealing, it was protected from light and stirred vigorously for 24 hours; the product was mixed with a large amount of ether, and the product was washed with saturated sodium bicarbonate solution 4 times, and stood still; after obtaining the upper ether organic layer, add anhydrous Magnesium sulfate, remove water overnight; filter with suction, then transfer the obtained liquid into a flask, spin dry the solvent with a rotary evaporator, dissolve the product of the previous step with petroleum ether, freeze the product in the refrigerator for 1 hour for recrystallization, filter while cold, and then Wash the product several times with ethanol, put the product in a vacuum oven and dry it for 24 hours to ...

Embodiment 2

[0039] Add 1.36g (0.01mol) of dry pentaerythritol, 50.00mL of dry tetrahydrofuran, and 8.22mL of dry triethylamine into the dry reaction flask, and dissolve 7.42mL (0.06mol) of 2-bromoisobutyryl bromide in 10.00 mL of tetrahydrofuran was slowly added dropwise to the flask; after sealing, it was protected from light and stirred vigorously for 24 hours; the product was mixed with a large amount of ether, and the product was washed with saturated sodium bicarbonate solution 4 times, and stood still; after obtaining the upper ether organic layer, add anhydrous Magnesium sulfate, remove water overnight; filter with suction, then transfer the obtained liquid into a flask, spin dry the solvent with a rotary evaporator, dissolve the product of the previous step with petroleum ether, freeze the product in the refrigerator for 1 hour for recrystallization, filter while cold, and then Wash the product several times with ethanol, put the product in a vacuum oven and dry it for 24 hours to ...

Embodiment 3

[0044] Add 1.36g (0.01mol) of dry pentaerythritol, 50.00mL of dry tetrahydrofuran, and 8.22mL of dry triethylamine into the dry reaction flask, and dissolve 7.42mL (0.06mol) of 2-bromoisobutyryl bromide in 10.00 mL of tetrahydrofuran was slowly added dropwise to the flask; after sealing, it was protected from light and stirred vigorously for 24 hours; the product was mixed with a large amount of ether, and the product was washed with saturated sodium bicarbonate solution 4 times, and stood still; after obtaining the upper ether organic layer, add anhydrous Magnesium sulfate, remove water overnight; filter with suction, then transfer the obtained liquid into a flask, spin dry the solvent with a rotary evaporator, dissolve the product of the previous step with petroleum ether, freeze the product in the refrigerator for 1 hour for recrystallization, filter while cold, and then Wash the product several times with ethanol, put the product in a vacuum oven and dry it for 24 hours to ...

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Abstract

The invention belongs to the fields of intelligent bionic materials, high-molecular materials and biomedical engineering, and concretely relates to a polydopamine particles-doped star-shaped polymer of a multi-responsive self-healing hydrogel, and the self-healing hydrogel and a preparation method thereof. In the present invention, the polydopamine nanoparticles and the star-shaped polymer SPDMAEMA-AA are prepared first; and the polydopamine nanoparticles, SPDMAEMA-AA and branched polyethyleneimine are mixed in proportion to form a crosslinked network by forming a dynamic reversible enamine bond through the acetoacetate on SPDMAEMA-AA and an amino group in the PEI molecules to obtain the hydrogel. The self-healing hydrogel material prepared by the invention has good near-infrared responsiveness, biocompatibility and high self-healing efficiency, and has potential applications in the fields of solid-state band-aids, drug slow release, cell culture, and a double-layer drive.

Description

technical field [0001] The invention belongs to the fields of intelligent bionic materials, polymer materials and biomedical engineering, and in particular relates to a star polymer and a self-healing hydrogel for synthesizing polydopamine particle-doped multi-responsive self-healing hydrogels and preparation method. technical background [0002] Self-healing polymer hydrogel has the ability to recover to its original strength and function when cracks appear inside and on the surface of the material, similar to the proliferation and differentiation of cells in biological tissues to achieve self-healing of biological organs Self-healing hydrogels achieve self-healing of materials through the breaking and reconnection of reversible covalent bonds and reversible non-covalent bonds. Self-healing endows hydrogel with multiple "lives", making it shine in applications such as biosensors, wound dressings, shape memory materials, and biomedical carriers. (Nasim A.; Su R.S. et al. A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/34C08F220/20C08F8/00C08G73/06C08J3/075C08L33/14C08L79/04C08L79/02
CPCC08F8/00C08F220/34C08F2438/01C08G73/0672C08J3/075C08J2333/14C08J2479/02C08J2479/04C08F220/20
Inventor 袁伟忠王春堯谢晓云李舒玥卫珺堃
Owner TONGJI UNIV
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