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Method for preparing calcium alginate microspheres with temperature response performance

A technology of calcium alginate and composite microspheres, applied in the field of materials, can solve the problems of lack of controlled release ability in response to physiological events, less research and application, and achieve good biocompatibility and biodegradability, wide application prospects, Simple and safe operation

Active Publication Date: 2011-02-02
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But at present, there are obvious deficiencies in alginate DDS: most alginate DDS only have a certain sustained release effect on drugs, and lack the ability to control release in response to physiological events (especially temperature changes)
Compared with PNIPAm, PVCL has better biocompatibility and lower toxicity, but there are less researches and applications on it

Method used

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  • Method for preparing calcium alginate microspheres with temperature response performance
  • Method for preparing calcium alginate microspheres with temperature response performance
  • Method for preparing calcium alginate microspheres with temperature response performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 0.4g sodium alginate, 0.8g N-ethylene caprolactam, 58.8g water in a 250mL three-necked flask, 0.02g azobisisobutyronitrile, that is, azobisisobutyronitrile is about 2.14% of the molar number of N-ethylenecaprolactam, Stir, fully mix and dissolve, remove oxygen such as filling with nitrogen for half an hour, then heat up to 60°C, and react for 5 hours. The reaction process can be accompanied by continuous stirring or intermittent stirring. The reaction mixture was cooled to room temperature, slowly added to 40 mL of n-hexane dissolved with 2 g of Span-85, stirred for 15 min, 2 g of Tween-85 (diluted with 2 mL of water) was added dropwise, and the emulsification was continued for 10 min. Finally, 25 mL of calcium chloride aqueous solution with a mass fraction of 8% was added dropwise, and stirred and solidified for 15 min. Precipitate with absolute ethanol, centrifuge, then wash with absolute ethanol and distilled water respectively, and freeze-dry to obtain the follo...

Embodiment 2

[0024] Roughly the same as the method of Example 1, the difference is that the consumption of sodium alginate, N-ethylene caprolactam, and azobisisobutyronitrile are respectively 0.6g, 0.6g, and 0.015g, and the above-mentioned azobisisobutyronitrile is about N - 2.12% by mole of ethylene caprolactam. The resulting finished product is as figure 2 shown.

Embodiment 3

[0026] Roughly the same as the method of Example 1, the difference is that 0.8g sodium alginate, 0.4g N-ethylene caprolactam, 0.01g azobisisobutyronitrile are added, and the above-mentioned azobisisobutyronitrile is about 1% of the moles of N-ethylene caprolactam 2.13%.

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Abstract

The invention discloses a method for preparing calcium alginate microspheres with temperature response performance, which comprises the following steps of: fully dissolving selected amount of N-vinylcaprolactam and the like and sodium alginate in water, preparing into aqueous solution, adding an initiator, uniformly mixing for deoxidation, and performing stirring reaction at constant temperature for 3 to 6 hours; cooling the reaction liquid obtained in the last step to room temperature, slowly adding into an oil phase in which an emulsifier 1 is dissolved for emulsification, adding into aqueous solution with an emulsifier 2 for emulsification, dripping a cross-linker with high-speed stirring, stirring, and curing; and precipitating the emulsion obtained in the last step by using absolute ethyl alcohol, performing centrifugal separation, washing with absolute ethyl alcohol and distilled water respectively, and performing freeze drying to obtain the finished product. The calcium alginate microspheres have certain temperature response performance, and the response temperature is near the physiological temperature; and the calcium alginate microspheres have good biocompatibility and biodegradability, and have wide application prospect in the field of biomedicines, particularly in the aspect of control release of medicines.

Description

technical field [0001] The invention belongs to the technical field of materials, and relates to a preparation method of microspheres with temperature response performance, in particular to a preparation method of calcium alginate composite microspheres with temperature response performance. Background technique [0002] The study of new and efficient drug controlled release materials and controlled release systems has always been the main way for humans to explore ways to improve drug release patterns, reduce toxic side effects, enhance absorption and therapeutic effects, and has attracted great attention from researchers in the fields of chemistry, materials science and pharmacy. interest. [0003] Alginic acid is a natural polysaccharide polymer extracted from seaweed, which is composed of (1→4) α-L-guluronic acid and (1→4) β-D-mannuronic acid relying on 1,4- The copolymerized polymer composed of glycosidic bonds is non-toxic, has good biocompatibility and degradability,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36C08F226/06C08F126/06C08L5/04C08L39/04C08F220/06B01J13/02A61K47/32
Inventor 马晓梅夏延致李银银纪全
Owner QINGDAO UNIV
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