Composite hydrogel and preparation method and application thereof

Abstract

The invention discloses composite hydrogel and a preparation method and application thereof. The composite hydrogel comprises a first network and a second network, wherein the second network semi-interpenetrates the first network; the first network comprises hydrogel formed by an isopropylacrylamide monomer and nanoparticles; the second network comprises a high-molecular polymer. The composite hydrogel can be applied to the field of biology and/or medicine. The composite hydrogel has a double-network structure, and has temperature responsiveness and ultrahigh mechanical properties. The preparation of the high-elasticity hydrogel adopts cheap and readily available raw materials and a mild preparation process, so that the preparation of the hydrogel is easy for large-scale production, and the application range of the hydrogel is expanded.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a composite hydrogel and its preparation method and application. Background technique [0002] Hydrogel contains a lot of water and has a three-dimensional network structure, so its application value in the biomedical field is becoming more and more obvious. It can be used as a biosensor, tissue engineering scaffold, bioseparation, drug release carrier, etc. These application areas have certain requirements on the biocompatibility and mechanical properties of the hydrogel, especially the tensile strength, while the traditional chemically cross-linked hydrogel has irregular cross-linking points, and the length of the polymer molecular chain The distribution is also uneven, which leads to poor mechanical properties and cannot meet the application requirements for higher mechanical properties. Traditional chemically cross-linked hydrogels often require the addition of small molec...

AI Technical Summary

Problems solved by technology

These application areas have certain requirements on the biocompatibility and mechanical properties of the hydrogel, especially the tensile strength, while the traditional chemically cross-linked hydrogel has irregular cross-linking points, and the length of the polymer molecular chain The distribution is also uneven, which leads to poor mechanical properties and cannot meet the application requirements for higher mechanical properties.

Traditional chemically cross-linked hydrogels often require the addition of small molecule chemical cross-linking agents, which have a great negative impact on the biocompatibility of hydrogels

[0003] Patent document CN107840926A discloses a fast-response high-strength hydrogel. The gel preparation method disclosed in the invention first prepares double-bond functionalized N-isopropylacrylamide microgel as a crosslinking agent to prepare the hydrogel. The technical scheme has many reaction steps, and the preparation method is cumbersome, which increases the operational difficulty of the preparation process and the control difficulty of the preparation results.

[0004] The preparation methods of hydrogels in the prior art are cumbersome, there are many intermediate reaction steps, and the reaction results are not easy to control. There are few reports on ultra-high-strength hydrogels with temperature responsiveness, and there are generally technical problems of poor mechanical strength. needs further improvement