Poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and preparation method thereof

A technology of hydroxyethyl methacrylate and hydroxypropyl cellulose, which can be used in medical preparations, medical science, prostheses and other directions of non-active ingredients, and can solve the problems of non-biodegradation of hydrogels.

Inactive Publication Date: 2010-11-10
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aforementioned hydrogels are not biodegradable
[0006] So far, there is no report on the synthesis of poly(L-glutamic acid-g-hydroxyethyl methacrylate) and hydroxypropyl cellulose-g-acrylic acid copolymer hydrogel

Method used

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  • Poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and preparation method thereof
  • Poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of poly(L-glutamic acid-g-hydroxyethyl methacrylate)

[0024] Mix 1.3g poly(L-glutamic acid) (viscosity average molecular weight: 88000) with 0.013g hydroxyethyl methacrylate monomer, dissolve it in 30mL dimethyl sulfoxide, dissolve all the solids, and define it as a solution a.

[0025]Then, 0.02 g of N, N'-cyclohexylcarbodiimide and 0.012 g of 4-dimethylaminopyridine were dissolved in 0.16 mL of dimethyl sulfoxide, which was defined as solution b. The above solution b was poured into the solution a, reacted at room temperature for 72 hours, and filtered off the generated precipitate. The filtrate was settled with 300 mL ether, filtered, washed three times with ether, and dried under vacuum at room temperature for 24 hours to obtain poly(L-glutamic acid-g-hydroxyethyl methacrylate).

Embodiment 2

[0026] Embodiment 2: the preparation of poly(L-glutamic acid-g-hydroxyethyl methacrylate)

[0027] Mix 1.3g poly(L-glutamic acid) (viscosity average molecular weight: 88000) with 0.656g hydroxyethyl methacrylate monomer, dissolve it in 30mL dimethyl sulfoxide, dissolve all the solids, and define it as a solution a. Then, 1.04 g of N, N'-cyclohexylcarbodiimide and 0.615 g of 4-dimethylaminopyridine were dissolved in 8.25 mL of dimethyl sulfoxide, which was defined as solution b. The above solution b was poured into the solution a, reacted at room temperature for 72 hours, and filtered off the generated precipitate. The filtrate was settled with 300 mL ether, filtered, washed three times with ether, and dried under vacuum at room temperature for 24 hours to obtain poly(L-glutamic acid-g-hydroxyethyl methacrylate).

Embodiment 3

[0028] Embodiment 3: the preparation of poly(L-glutamic acid-g-hydroxyethyl methacrylate)

[0029] Mix 1.3g poly(L-glutamic acid) (viscosity-average molecular weight: 88000) with 0.13g hydroxyethyl methacrylate monomer, dissolve it in 30mL dimethyl sulfoxide, dissolve all the solids, and define it as a solution a. Then, 0.2 g of N, N'-cyclohexylcarbodiimide and 0.12 g of 4-dimethylaminopyridine were dissolved in 1.6 mL of dimethyl sulfoxide, which was defined as solution b. The above solution b was poured into the solution a, reacted at room temperature for 72 hours, and filtered off the generated precipitate. The filtrate was settled with 300 mL ether, filtered, washed three times with ether, and dried under vacuum at room temperature for 24 hours to obtain poly(L-glutamic acid-g-hydroxyethyl methacrylate).

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Abstract

The invention provides a poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the step of carrying out copolymerization synthesis on poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the free radical of hydroxy propyl cellulose-g-acrylic acid, wherein the mass percent between the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and the hydroxy propyl cellulose-g-acrylic acid is 10-90%: 90-10%. The obtained hydrogel has the characteristics ofthe two homopolymers and is sensitive for the temperature and the pH; and furthermore, the poly (L-glutamic acid) part in the hydrogel can be biodegradable, so that the material can not be accumulated in the body, and the poly (L-glutamic acid-g-hydroxy-ethyl methacrylate) and hydroxy propyl cellulose-g-acrylic acid copolymer hydrogel can be taken as a novel intelligent drug release carrier.

Description

technical field [0001] The invention relates to a poly(L-glutamic acid-g-hydroxyethyl methacrylate) and hydroxypropyl cellulose-g-acrylic acid copolymerized hydrogel and a preparation method. Background technique [0002] Intelligent polymer hydrogel is a type of polymer that can make physical or chemical responses when the external environment (temperature, pH value, solution ionic strength or electric field strength) changes, and its shape, volume and water absorption performance change dramatically. , due to the unique responsiveness of smart gels under environmental stimuli, it has broad application prospects in the field of biomedical materials. Among them, pH- and temperature-sensitive hydrogels have attracted attention because they are closely related to human physiological conditions, and are widely used in the fields of biomedicine and pharmacy, such as temperature-sensitive tissue engineering hydrogels, pH-sensitive targeted drug release carriers, etc. [0003] Hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08F283/04C08F251/02C08J3/075A61K47/38A61L27/20A61L27/52
Inventor 陈莉张喆白云艳单红玲陈学思庄秀丽
Owner NORTHEAST NORMAL UNIVERSITY
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