Preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel

A composite hydrogel and semi-interpenetrating technology, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of short release time, poor degradation performance, and difficulty in drug entry. Achieve good biocompatibility, high water content, and high crystallinity

Inactive Publication Date: 2018-05-08
吴刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a porous semi Preparation method of interpenetrating thermosensitive composite hydrogel

Method used

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  • Preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel

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example 1

[0022] Take 20g of glucose, 3g of yeast extract, 15g of agar, and 5g of peptone, add them to 800mL of deionized water, stir at 300r / min for 20min, and adjust the pH to 5.0 with citric acid, then place them in an autoclave at 121°C, Sterilize for 20 minutes to obtain the fermentation medium, inoculate Acetobacter xylinum into 100 mL of fermentation medium according to the inoculum amount of 5% (V / V), cultivate it in a constant temperature incubator at 30°C for 8 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 100mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 70°C for 1 hour and then replace the hydrogen Repeat the soaking operation in sodium oxide solution 3 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. Take ...

example 2

[0024] Take 22g of glucose, 4g of yeast extract, 17g of agar, and 6g of peptone, add it to 900mL of deionized water, stir at 350r / min for 25min, and adjust the pH to 5.5 with citric acid, then place it in an autoclave at 123°C, Sterilize for 25 minutes to obtain the fermentation medium, inoculate Acetobacter xylinum into 110 mL of fermentation medium according to the inoculum amount of 6% (V / V), cultivate it in a constant temperature incubator at 31°C for 9 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 150 mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 75°C, soak for 1 hour, and then replace the hydrogen Repeat the soaking operation in sodium oxide solution 4 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. T...

example 3

[0026]Take 25g of glucose, 5g of yeast extract, 20g of agar, and 8g of peptone, add it to 1000mL of deionized water, stir at 400r / min for 30min, and adjust the pH to 6.0 with citric acid, then place it in an autoclave at 125°C, Sterilize for 30 minutes to obtain the fermentation medium, inoculate Acetobacter xylinum into 120 mL of fermentation medium according to the inoculum amount of 8% (V / V), culture it in a constant temperature incubator at 32°C for 10 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 200mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 80°C for 2 hours and then replace the hydrogen Repeat the soaking operation in sodium oxide solution 5 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. Take 14g ...

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Abstract

The invention relates to a preparation method of porous semi-interpenetrating temperature-sensitive composite hydrogel, and belongs to the technical field of biological materials. The preparation method is characterized in that natural cellulose which has a unique nano-fiber three-dimensional mesh structure, a good medicine carrying property, high water content, high crystallinity, high purity andgood biocompatibility and is synthesized by microorganism fermentation is taken as a main network, and the monomer of a temperature-sensitive material, namely monor of 2-(dimethylamino)ethyl methacrylate is introduced into a nano-fiber network to be polymerized into a second network structure to form semi-interpenetrating composite gel with shorter gelation time, so that the bacterial cellulose material has temperature response and can quickly respond to water loss stimulated by external temperature, and medicines inside the hydrogel can be smoothly released from the inside of the gel to achieve a long-term slow-release effect by virtue of the network structure inside the hydrogel and the self-degradation action of the hydrogel.

Description

technical field [0001] The invention relates to a preparation method of a porous semi-interpenetrating temperature-sensitive composite hydrogel, which belongs to the technical field of biomaterials. Background technique [0002] In the process of disease treatment, drugs enter the body through various ways in clinical practice to achieve therapeutic effects. However, due to the shortcomings of the drug itself, such as short half-life, high self-toxicity, lack of selectivity, and the decomposition of the drug by enzymes and self-metabolism in the body, some drugs such as granulocyte colony-stimulating factor, interferon, granulocyte-giant cell Protein drugs such as colony-stimulating factor and small-molecule drugs such as paclitaxel and doxorubicin have a short action time after entering the body, and the toxic effect is relatively large, and only a small part of the drugs can really play a role, and increasing drug concentration or frequent administration Drugs often cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/14C08L1/02C08F220/34C08F222/38A61K9/06A61K47/32A61K47/38
CPCA61K9/06A61K47/32A61K47/38C08F220/34C08J3/075C08J2333/14C08J2401/02C08F222/385
Inventor 姚星宇王文新史玉兰
Owner 吴刚
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