Anti-adhesion endocranium prepared by physical sedimentation method

A dura mater and physical method technology, applied in the field of medical biomaterials, can solve the problems of hard and difficult to adhere materials, easy to cause adhesion, etc.

Inactive Publication Date: 2013-04-03
TIANJIN SANNIE BIOENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. Fully adhered to the surface of brain tissue and prone to adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1.0 g of commercially available type I collagen and 0.5 g of commercially available chitosan, and dissolve them in 100 ml of 0.2 mol / L acetic acid solution. After completely dissolving, the mixture was poured into a mold tray, placed on an automatic shaker, and shaken automatically for 60 minutes, and finally the obtained biofilm was dehydrated to make its water content 40.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 2:1.

Embodiment 2

[0011] 10.0 g of commercially available type I collagen and 3.0 g of commercially available chitosan were dissolved in 100 ml of 0.05 mol / L acetic acid solution. After completely dissolving, pour the mixed liquid into the mold tray, put it on an automatic shaker, shake it automatically for 120 minutes, and finally dehydrate the obtained biofilm to make its water content 10.0%. Sterilized by irradiation after sealing the package. The mass ratio of type I collagen: chitosan is 10:3.

Embodiment 3

[0013] Take 2.0 g of commercially available type I collagen and 0.5 g of commercially available chitosan, and dissolve them in 100 ml of 0.01 mol / L acetic acid solution. After completely dissolving, pour the mixed liquid into the mold tray, put it on an automatic shaker, and shake it automatically for 30 minutes, and finally dehydrate the obtained biofilm to make its water content 1.0%. Sterilized by irradiation after sealing the packaging. The mass ratio of type I collagen: chitosan is 4:1.

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PUM

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Abstract

The invention describes stent materials for clinical endocranium reconstitution and a preparation method thereof, belonging to the field of medical biomaterials and mainly solving the problems that clinically suture is needed for endocranium repair and endocranium is prone to adhesion at present. The aim of endocranium repair is achieved by providing a bioactive matrix which has a certain pore diameter and viscosity and adding anti-adhesion chitosan to one layer of the product for the endocranium receptor. The materials prepared by the method are I type collagens of different concentrations and intrinsic three-dimensional structures of the I type collagens and chitosan in different space, are uniform, have certain viscosity, reduce the surgical suture operation, adopts the chitosan anti-adhesion layer on the basis of maintaining the original activities of the I type collagens, reduce the probability of adhesion with cranium after surgery, have good biocompatibility and are beneficial to endocranium repair and reconstitution.

Description

technical field [0001] The invention relates to a chitosan and type I collagen mixed in a certain ratio to form a structural reconstruction of chitosan and type I collagen, and then physically separate the type I collagen not combined with chitosan to form multi-chitosan Sugar with type I collagen layer and type I collagen layer method to prepare biofilm material. It is a light yellow, soft, porous, viscous product with good biocompatibility. Dural substitute materials for dural repair in brain surgery. It belongs to the field of medical biomaterials. Background technique [0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. It is completely attached to the surface of br...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/24A61L27/20
Inventor 万力张春红
Owner TIANJIN SANNIE BIOENG TECH
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