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Pleura/meninges patch and preparation method thereof

A technology of meninges and pleura, applied in the field of pleura/meninges and its preparation, can solve the problems of incompatibility of biocompatibility and mechanical properties, complicated preparation process, etc.

Inactive Publication Date: 2015-11-25
SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose a pleura / meninges and its preparation method to solve the technical problems in the above-mentioned prior art that the preparation process is complex and the biocompatibility and mechanical properties cannot be achieved at the same time

Method used

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  • Pleura/meninges patch and preparation method thereof
  • Pleura/meninges patch and preparation method thereof
  • Pleura/meninges patch and preparation method thereof

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preparation example Construction

[0031] A kind of preparation method of pleura / meninges that the present invention proposes, comprises the following steps:

[0032] S1. According to the solid-liquid ratio of 1:100~5:100g / ml, the degree of deacetylation is greater than 60%, and the molecular weight is greater than 0.5×10 6 The squid cartilage chitosan or squid cartilage chitosan powder is dissolved into glue;

[0033] S2. After filtering the glue solution and degassing, spin coating to obtain pleura / meninges.

[0034] Wherein, the preparation of squid cartilage chitosan in step S1 comprises:

[0035] S11. Dissolve squid cartilage β-chitin or squid cartilage chitosan in a NaOH solution with a mass percent concentration of 30% to 40% according to a solid-liquid ratio of 5.0:100 to 25:100 g / ml, at 50 to 80 After stirring at ℃ for 1-6 hours, filter to obtain the filter residue;

[0036] S12, washing the filter residue obtained in step S11 until neutral and then drying to obtain squid cartilage chitosan used in ...

Embodiment 1

[0059] The present embodiment proposes a preparation method of pleura / meninges, comprising the following steps:

[0060] S1, 1.3g squid cartilage chitosan (DD=75%, MW=1.52×10 6 ) powder is dissolved in 100mL of acetic acid solution with a mass percentage concentration of 2%, and is configured into a glue;

[0061] S2, spin-coating (r=2000rad / min, t=9s) through filtering, defoaming glue solution, obtains chitosan film;

[0062] S3. After drying the chitosan film in a blast drying oven at 60°C, wash it with dilute alkali solution and deionized water, and dry it again in a blast drying oven at 60°C to obtain a pleural / meningeal patch.

[0063] Wherein, the preparation of squid cartilage chitosan powder in step S1 comprises:

[0064] S11. According to the solid-liquid ratio of 10:100 (g / ml), the squid cartilage β-chitin was dissolved in a NaOH solution with a concentration of 35% by mass, stirred at 80° C. for 2 hours, and then filtered to obtain a filter residue;

[0065] S12....

Embodiment 2

[0073] The present embodiment proposes a preparation method of pleura / meninges, comprising the following steps:

[0074] S1, 1.5g squid cartilage chitosan (DD=95%, MW=1.15×10 6 ) powder is dissolved in 100mL of acetic acid solution with a mass percentage concentration of 2%, and is configured into a glue;

[0075] S2, spin-coating (r=2500rad / min, t=10s) through filtering, defoaming glue solution, obtains chitosan film;

[0076] S3. After drying the chitosan film in a blast drying oven at 60°C, wash it with dilute alkali solution and deionized water, and dry it again in a blast drying oven at 60°C to obtain a pleural / meningeal patch.

[0077] Wherein, the preparation of squid cartilage chitosan powder in step S1 comprises:

[0078] S11. The squid cartilage chitosan prepared in Example 1 (DD=75%, MW=1.52×10 6 ) powder was dissolved in NaOH solution with a concentration of 30% by mass, stirred at 50°C for 4 hours, and then filtered to obtain a filter residue;

[0079] S12. Wa...

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Abstract

The invention discloses a pleura / meninges patch and a preparation method thereof. The preparation method comprises the following steps: S1, dissolving squid cartilage chitosan to form a glue solution, wherein the deacetylation degree of the squid cartilage chitosan is greater than 60% and the molecular weight of the squid cartilage chitosan is greater than 0.5*10<6>; and S2, coating the glue solution to obtain the pleura / meninges patch. The pleura / meninges patch prepared by the method is capable of effectively promoting regeneration and rehabilitation of pleura and endocranium of a human body, is finally degraded and absorbed in vivo, and has relatively high clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a pleura / meninges and a preparation method thereof. Background technique [0002] The dura mater and the pleura are important functional membrane tissues between the brain and the skull, the inner surface of the chest wall and the upper surface of the diaphragm, and the surface of the lung, respectively, and have similar biological characteristics and functions. Dural and pleural defects are mainly caused by tumor resection, trauma, inflammation, viral infection and radiation damage. Improper repair of the dura mater often causes cerebrospinal fluid leakage, meningeal tissue adhesion, and formation of brain tissue scarring, which can lead to epilepsy in severe cases; and chest wall defects will not only affect the appearance, but also be accompanied by varying degrees of thoracic internal organ damage, and the area is relatively large Chest wall defects often cause abnormal...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/54A61L27/58C08B37/08
CPCA61L27/20A61L27/58C08J5/18
Inventor 吴奕光冯奕清黎剑辉江长兵吴灿光
Owner SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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