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Preparation of bergenin in aruneus dioicus

A kind of technology of rock cabbage element and pseudocimicha root, which is applied in the research and development field of affiliated pharmaceutical products

Inactive Publication Date: 2010-09-01
SHANDONG UNIV AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few reports at home and abroad on the research on the phytochemical components of False Cohosh

Method used

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  • Preparation of bergenin in aruneus dioicus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Step (1): Take 2.3 kg of dried cohosh roots and crush them, soak them in 50% ethanol for 10 hours, and then sonicate them for 1 hour at a temperature of 30°C and a power of 80W. Repeat 3 times, then filter with gauze to obtain the filtrate;

[0017] Step (2): Combine the filtrates in step (1), concentrate, suspend the concentrate in water, and extract with petroleum ether, ethyl acetate, and n-butanol in sequence, and concentrate to recover the extraction solvent to obtain four parts;

[0018] Step (3): Dissolve 13.8 g of the ethyl acetate part in step (2) with methanol, mix the sample with 16 g silica gel, and load a 360 g, 100-200 mesh silica gel column, pack the column with chloroform, and elute with a chloroform-methanol gradient;

[0019] Step (4): Combine the similar fractions in step (3), concentrate to obtain a concentrated solution, and further use silica gel column chromatography;

[0020] Step (5): Combine the similar fractions in step (4), concentrate to obtain a con...

Embodiment 2

[0023] Step (1): Take 2.5 kg of dry roots of fake cohosh and crush them, soak in 50% ethanol for 12 hours, then ultrasonicate for 1.5 hours, temperature 30°C, power 80W, repeat 3 times, then filter with gauze to obtain filtrate;

[0024] Step (2): Combine the filtrates in step (1), concentrate, suspend the concentrate in water, and extract with petroleum ether, ethyl acetate, and n-butanol in sequence, and concentrate to recover the extraction solvent to obtain four parts;

[0025] Step (3): Dissolve 14 g of the ethyl acetate portion in step (2) with methanol, mix the sample with 16 g of silica gel, and apply a 360 g, 100-200 mesh silica gel column, pack the column with chloroform, and elution with a chloroform-methanol gradient;

[0026] Step (4): Combine the similar fractions in step (3), concentrate to obtain a concentrated solution, and further use silica gel column chromatography;

[0027] Step (5): Combine the similar fractions in step (4), concentrate to obtain a concentrated so...

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Abstract

The invention belongs to the technical field of the research and development of medical products, relating to preparation of bergenin in aruneus dioicus. A preparation method comprises the steps of: pulverizing dried aruneus dioicus, soaking for 10-12 hours in 50 percent of alcohol, carrying out ultrasound for 1-1.5 hours with the temperature of 30 DEG C and the power of 80W, repeating 3 times, filtering by using gauze, merging filtrate, concentrating, blending and suspending by using water, sequentially extracting by using petroleum ether, ethyl acetate and n-butyl alcohol, concentrating the recovered extracting solvent to obtain four parts, dissolving an ethyl acetate part by using methanol, blending a sample by using silicagel, loading on a silicagel column, assembling the column by using chloroform, carrying out gradient elution by using chloroform-methanol, merging similar fractions, concentrating, further carrying out chromatography by using the silicagel column, merging similar fractions, concentrating, separating out crystal and obtaining a bergenin monomer by using a recrystallization method. The bergenin has the main effect of relieving a cough and eliminating phlegm, also has the effects of anti-inflammation, liver protection, anti-ulcer, immune improvement and the like and can be further used for the research and development of corresponding preparation products used for clinical applications.

Description

Technical field [0001] The invention belongs to the technical field of research and development of medical products. The present invention relates to the preparation of Bergenin from the roots of pseudocohosh. The main function of the product of the invention is to relieve cough and expectorant, and also has the functions of anti-inflammatory, liver protection, anti-ulcer, and immunity improvement. The corresponding preparation products can be further researched and developed for clinical use. Background technique [0002] The invention relates to the preparation of bergenin by using pseudocimise root as a raw material. Aruncus sylvester Kostel.ex Maxim. is the dried root of Aruncus pseudocohosh in the Rosaceae family. Alias: Ditang Hui Ma, medicinal function: disperse wind and relieve the surface, invigorate blood and relax muscles. Distribution area: Produced in Heilongjiang, Jilin, Liaoning, Henan, Gansu, Shaanxi, Hunan, Jiangxi, Anhui, Zhejiang, Sichuan, Yunnan, Guangxi, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04
Inventor 张崇禧郑友兰雷兵
Owner SHANDONG UNIV AT WEIHAI
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