Method for detecting quality of An'erning granules

A quality inspection method, the technology of Anerning Granules, which is applied in the field of quality inspection of Anerning Granules, can solve the hidden dangers buried in clinical use, and the quality of Anerning Granules cannot be guaranteed.

Active Publication Date: 2012-07-18
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the current quality inspection standard of Anerning Granules includes the identification of bile acid and the determination of bilirubin content. This quality inspection method cannot guarantee the quality of Anerning Granules, which has laid hidden dangers for clinical use.

Method used

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  • Method for detecting quality of An'erning granules
  • Method for detecting quality of An'erning granules
  • Method for detecting quality of An'erning granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Embodiment 1: Preparation of Anning Granules

[0169] The raw materials of Anning Granules are composed of:

[0170] Safflower 53.3g White Sandalwood 66.7g

[0171] Licorice 53.3g Alpine horseradish 53.3g

[0172] Rock cabbage 53.3 grams Tianzhu yellow 66.7 grams

[0173] Short tube rabbit ear grass 66.7g Tangut aconitum 66.7g

[0174] 5.3 grams of artificial bezoar, 930 grams of sucrose.

[0175] Anning Granules are prepared by the following method:

[0176] Add 5 times the amount of safflower and white sandalwood to extract for 3 hours, collect the volatile oil, filter, combine the dregs with licorice, mountain horseradish, rock cabbage, geranium yellow, short-tube rabbit grass and aconitum tangut, add water and decoct 2 times, add 10 times the amount of water for the first time to decoct for 2 hours, add 8 times the amount of water for the second time to decoct for 2 hours, filter, combine the filtrates, and concentrate to a clear solution of ρ=1.02~1.04 (measur...

Embodiment 2

[0179] Embodiment 2: the quality detection method of An Er Ning granule described in embodiment 1

[0180] Identification:

[0181] A. Take 2g of Anerning granules, grind them finely, add 10ml of acetone, ultrasonically treat for 20 minutes, filter, and concentrate the filtrate to 1ml as the test solution; Make a mixed solution containing 0.2mg per 1ml, as the reference substance solution; test according to thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia 2000 edition), draw 10 μl of each of the above two solutions, and spot on the same silica gel G thin layer respectively. On the board, use ether-chloroform-glacial acetic acid (2:2:1) as the developing agent, develop, take out, dry in the air, spray with 10% sulfuric acid ethanol solution, heat at 105°C for several minutes, and place an ultraviolet lamp (365nm) Under the inspection; in the chromatogram of the test product, at the position corresponding to the chromatogram of the reference product, there are fl...

Embodiment 3

[0202] Embodiment 3: the quality detection method of An Er Ning granule described in embodiment 1

[0203] Identification:

[0204] A. Take 2g of Anerning granules, grind them finely, add 10ml of acetone, ultrasonically treat for 20 minutes, filter, and concentrate the filtrate to 1ml as the test solution; Make a mixed solution containing 0.2mg per 1ml, as the reference substance solution; test according to thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia 2000 edition), draw 10 μl of each of the above two solutions, and spot on the same silica gel G thin layer respectively. On the board, use ether-chloroform-glacial acetic acid (2:2:1) as the developing agent, develop, take out, dry in the air, spray with 10% sulfuric acid ethanol solution, heat at 105°C for several minutes, and place an ultraviolet lamp (365nm) Under the inspection; in the chromatogram of the test product, at the position corresponding to the chromatogram of the reference product, there are fl...

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Abstract

The invention discloses a method for detecting the quality of An'erning granules. The method comprises a method for identifying cholic acid and bergenin and a method for determining content of glycyrrhizic acid, the bergenin and bilirubin. Experimental study proves that spots with different colors are displayed at a position, which corresponds to a color spectrum of a reference substance, in the color spectrum of a sample by the identification method in the quality detection method; and negative control is not interfered. Results show that the content determination method is used for determining the content of the glycyrrhizic acid and the bergenin in the An'erning granules, has a good linear relation, and high repeatability and stability, and can control the quality of An' erning granules accurately and strictly; and moreover, the accuracy of recovery tests is high.

Description

technical field [0001] The invention relates to a quality detection method of a pharmaceutical composition, in particular to a quality detection method of Anerning Granules. Background technique [0002] Anerning Granules are recorded in the National Drug Standards, standard number: WS-10640(ZD-0640)-2002. It has the functions of clearing away heat and expelling wind, resolving phlegm and relieving cough. For children with wind-heat and cold, cough with phlegm, fever and sore throat, and upper respiratory tract infection with the above syndromes. [0003] Pediatric upper respiratory tract infection, cold, cough and asthma are common clinical diseases and frequently-occurring diseases. There are many treatment methods, but the effects are different. An Er Ning Granule is a traditional ancient prescription of Tibetan medicine. After long-term clinical application of Tibetan medicine, the medicine has the effect of clearing heat, detoxifying, dispelling wind and resolving phl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899G01N30/02G01N30/36G01N30/90A61P11/04A61P11/10A61P11/14A61P29/00A61K35/413
Inventor 张义智马振元李怀平李丽孙绪丁
Owner JINHE TIBETAN MEDICINE
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