Oral disintegration tablet of bergenin and compound bergenin and preparation method

A technology of orally disintegrating tablets and petogenin, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc., and can solve problems such as difficulty in taking

Inactive Publication Date: 2005-08-31
王红喜 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets require a lot of water to be taken down, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing, inconvenient water intake, and cough and asthma patients to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Direct taste correction method——Phenicin Orally Disintegrating Tablets

[0040] 1. Prescription

[0041] 1. Raw material - 125.0g of petogenin;

[0042] 2. Adhesive - hydroxypropyl methylcellulose 2.0g;

[0043] 3. Filling agent - mannitol 168.0g;

[0044] Microcrystalline cellulose 20.0g;

[0045]4. Flavoring agent - aspartame 3.5g;

[0046] Mint essence 3.5g;

[0047] 5. Disintegrant—cross-linked polyvinylpyrrolidone 10.5g;

[0048] Croscarmellose Sodium 10.5g;

[0049] 6. Glidant—micronized silica gel 3.5g;

[0050] 7. Lubricant—magnesium stearate 3.5g.

[0051] A total of 350g, a total of 1000 pieces were made.

[0052] 2. Preparation method

[0053] 1) Mix the petracenin raw material and part of the mannitol powder, pulverize it, and set aside;

[0054] 2) Dissolving hydroxypropyl methylcellulose (preferably 3 to 50 centipoise) with an appropriate amount of ethanol solution for later use;

[0055] 3) Use the...

Embodiment 2

[0059] Example 2 Coating Taste-Masking Method——Compound Petronassin Orally Disintegrating Tablets

[0060] 1. Prescription

[0061] 1. Raw material - 125.0g of petogenin;

[0062] Chlorpheniramine maleate 2.0g;

[0063] 2. Coating material - ethyl cellulose 18.7g;

[0064] Methylcellulose 6.3g;

[0065] 3. Filling agent - mannitol 147.0g;

[0066] Microcrystalline cellulose 17.5g;

[0067] 4. Flavoring agent - aspartame 2.0g;

[0068] Mint essence 3.5g;

[0069] 5. Disintegrant—cross-linked polyvinylpyrrolidone 9.0g;

[0070] Croscarmellose Sodium 9.0g;

[0071] 6. Glidant—micronized silica gel 6.5g;

[0072] 7. Lubricant—magnesium stearate 3.5g.

[0073] A total of 350g, a total of 1000 pieces were made.

[0074] 2. Preparation method

[0075] 1) Take chlorpheniramine maleate, mix it with petracenin by incremental dilution method, and set aside;

[0076] 2) Dissolve ethyl cellulose and methyl c...

Embodiment 3

[0081] Example 3 Effervescent Flavor Correction——Compound Petronassin Orally Disintegrating Tablets

[0082] 1. Prescription

[0083] 1. Raw material - 125.0g of petogenin;

[0084] Chlorpheniramine maleate 2.0g;

[0085] 2. Adhesive - hydroxypropyl methylcellulose 5.0g;

[0086] 3. Effervescent agent—anhydrous citric acid 33.0g;

[0087] Sodium bicarbonate 30.0g;

[0088] 4. Filling agent - mannitol 148.0g;

[0089] PROSOLV  SMCC 16.5g;

[0090] 5. Flavoring agent - aspartame 2.0g;

[0091] Orange essence 3.5g;

[0092] 6. Disintegrant—croscarmellose sodium 15.0g;

[0093] Low-substituted hydroxypropyl cellulose 12.0g;

[0094] 7. Glidant—micronized silica gel 4.0g;

[0095] 8. Lubricant—magnesium stearate 4.0g.

[0096] A total of 400g, a total of 1000 pieces were made.

[0097] 2. Preparation method

[0098] 1) Take chlorpheniramine maleate, mix it with petracenin by incremental dilution method, and ...

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PUM

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Abstract

An orally-disintegrating tablet of bergenin for treating cough, chronic trachetitis and other inflammations is prepared from bergenin, filler, disintegrant, flavouring, flow aid, lubricant, and optional adhesive or coating and effervescent agent.

Description

technical field [0001] The invention relates to a kind of orally disintegrating tablet of petracenin and compound petracenin which has the effects of antitussive, expectorant, anti-inflammatory, antipyretic and antiviral, and can comprehensively treat chronic bronchitis and its preparation process. Background technique [0002] Bicengenin is an isocoumarin compound extracted and refined from Xinjiang saxifrage plant Rock Cabbage. Studies have shown that Bicengenin has the following effects: [0003] ①Potent antitussive: The antitussive strength is about one-fourth that of codeine, and it relieves cough quickly. And it has a selective inhibitory effect on the cough center, but has no obvious inhibitory effect on other centers, and avoids the side effects of central inhibition of morphine antitussives. [0004] ② Strong expectorant: Its action strength is equivalent to that of Platycodon grandiflorum in the same dose, and it can expel bronchial pathological secretions and kee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/366A61K31/4402A61P11/10A61P11/14A61P29/00A61P31/12
Inventor 王红喜易薇
Owner 王红喜
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