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Medicine composite containing dextromethorphan hydrobromide

A technology of dextromethorphan hydrobromide and its composition, which is applied in the field of medicine, can solve problems such as poor stability, bad taste, and decreased content, and achieve the effects of drug stability, good absorption, and rapid cough relief

Active Publication Date: 2012-09-19
HUNAN DINUO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation has poor stability, after three months of storage, the content decreased by nearly 2%, and after six months of storage, the content decreased by more than 3%
In addition, the preparation tastes bad, sweet and bitter

Method used

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  • Medicine composite containing dextromethorphan hydrobromide
  • Medicine composite containing dextromethorphan hydrobromide
  • Medicine composite containing dextromethorphan hydrobromide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Ingredients Dosage

[0053] Dextromethorphan Hydrobromide 1.5g

[0054] β-cyclodextrin 8g

[0055] Sucrose 200g

[0056] Sodium Benzoate 2g

[0057] Dissolve β-cyclodextrin and sucrose in 800ml of water, heat to 50°C to completely dissolve, then add dextromethorphan hydrobromide at 50°C and keep stirring for 1 hour, let cool, add sodium benzoate, and use 5% citric acid solution Adjust PH4-6. Make up water to 1000ml, filter, pack into cans, seal, and sterilize.

Embodiment 2

[0059] Ingredients Dosage

[0060] Dextromethorphan Hydrobromide 1.5g

[0061] HP·β-cyclodextrin 15g

[0062] Mannitol 250g

[0063] Sodium Benzoate 2g

[0064] Dissolve HP-β-cyclodextrin and mannitol in 800ml of water, heat to 50°C to completely dissolve, then add dextromethorphan hydrobromide at 50°C and keep stirring for 1 hour, let it cool, add sodium benzoate, and use 5% citrate The citric acid solution is adjusted to pH 4-6. Make up water to 1000ml, filter, pack into cans, seal, and sterilize.

Embodiment 3

[0066] Ingredients Dosage

[0067] Dextromethorphan Hydrobromide 1.5g

[0068] MD·β-cyclodextrin 10g

[0069] Stevia 0.15g

[0070] Sodium Benzoate 2g

[0071] Dissolve MD·β-cyclodextrin and stevioside in 800ml of water, heat to 50°C to completely dissolve, then add dextromethorphan hydrobromide at 50°C and keep stirring for 1 hour, let it cool, add sodium benzoate, and use 5% citrate The citric acid solution is adjusted to pH 4-6. Make up water to 1000ml, filter, pack into cans, seal, and sterilize.

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Abstract

The invention provides a medicine composite containing dextromethorphan hydrobromide, which contains cyclodextrin, the weight of which is 5-20 times that of the dextromethorphan hydrobromide, wherein the cyclodextrin is beta-cyclodextrin. The oral dextromethorphan hydrobromide composite can quickly relieve a cough with quick effect, good absorption, high absorptivity of above 98%, no bitter tasteand good mouthfeel.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an oral pharmaceutical composition based on dextromethorphan hydrobromide. Background technique [0002] Dextromethorphan hydrobromide is a synthetic morphine-like central antitussive drug. This product has the same efficacy as codeine, and like codeine, it also acts on the central nervous system to increase cough threshold, but it is not addictive. Dextromethorphan is the safest cough suppressant available. Most of the antitussive preparations (Western medicines) available on the market without a prescription contain this ingredient. The drug is an essential drug (category B) included in the national essential drug list of our country. At present, there are many antitussive drugs, such as Chinese Pharmacopoeia 2010, United States Pharmacopoeia USP32, British Pharmacopoeia BP2010 and Japanese Pharmacopoeia Prescription JB 15 Corrected Edition, etc., have detailed reports, but the stabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K47/40A61P11/14
Inventor 黄云李学林张林春林泉
Owner HUNAN DINUO PHARMA
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