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Method for extracting bergenin from traditional Chinese medicine rodgersia podophylla

A technology for leucanthemum and Chinese medicinal materials, which is applied in the field of traditional Chinese medicine chemistry research, can solve the problems of unsuitability for industrial production, time-consuming and the like, and achieves the effects of low cost, high extraction rate and simple process

Inactive Publication Date: 2011-02-16
罗定强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultrasonic extraction with methanol is not suitable for industrial production, and the extraction method of lime water is time-consuming

Method used

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  • Method for extracting bergenin from traditional Chinese medicine rodgersia podophylla
  • Method for extracting bergenin from traditional Chinese medicine rodgersia podophylla
  • Method for extracting bergenin from traditional Chinese medicine rodgersia podophylla

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) Take the Chinese medicinal material Guidenghua coarse powder as raw material,

[0031] 2) Use 90% methanol with 4 times the concentration of the raw material to reflux extract the raw material for 3 times, the first time is 1 hour, the second and third times are both 0.5 hours, the result is that the extraction rate of petogenin is 60% %,

[0032] 3) The extracts were combined, and some crystals were precipitated after standing for 8 hours.

[0033] 4) Filter the liquid placed in 3),

[0034] 5) Recover the filtrate and concentrate to a small volume, and put it until crystallization occurs.

[0035] 6) Dissolve the crystals in a mixed solvent of ethanol-methanol with a volume ratio of 8:1, then heat-filter, and set aside to crystallize after filtering. In this process, the precipitation and crystallization are fast, and the solvent volume is relatively large.

[0036] After the above steps, white crystals were obtained, and the purity was over 97% through high pe...

Embodiment 2

[0038] 1) Take the Chinese medicinal material Guidenghua coarse powder as raw material,

[0039] 2) Use 93% ethanol that is 6 times the amount of the raw material to reflux the raw material for 3 times, the first time is 2 hours, the second and third times are 1 hour, and the extraction rate of petogenin is 75%. %,

[0040] 3) The extracts were combined, and some crystals were precipitated after standing for 18 hours.

[0041] 4) Filter the liquid placed in 3),

[0042] 5) recover the filtrate and concentrate to a small volume,

[0043] 6) Wash the precipitated crystals in step 5) with acetone,

[0044] 7) Decolorize the crystals in step 6) with activated carbon once,

[0045] 8) Dissolve the crystals in a mixed solvent of ethanol-methanol with a volume ratio of 8:3, then heat filter, and place the crystallization after filtration. This process precipitates crystallization faster, and the volume of solvent is appropriate.

[0046] Through the above steps, white crystals...

Embodiment 3

[0048] 1) Take the Chinese medicinal material Guidenghua coarse powder as raw material,

[0049] 2) Use ethanol with a concentration range 5 times that of the raw material to reflux extract the raw material for 3 times, the previous time was 3 hours, the second and third times were both 1.5 hours, and the extraction rate of petogenin was 80%.

[0050] 3) Collect the extract and leave it for 24 hours,

[0051] 4) Filter the precipitated solution,

[0052] 5) recover the filtrate and concentrate to a small volume,

[0053] 6) Dissolve the washed precipitate with a mixed solvent of ethanol-methanol with a concentration of 8:5, then heat filter, and place it for crystallization after filtration. During this process, the precipitation of crystals is slow, and the solvent volume is relatively small.

[0054] After the above steps, white crystals were obtained, and the purity was over 97% through high performance liquid chromatography and area normalization determination, and the ...

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Abstract

The invention belongs to the field of chemical research of traditional Chinese medicine, in particular to a method for extracting bergenin from traditional Chinese medicine rodgersia podophylla. In the prior art, methanol ultrasonic is used for extracting bergenin, which is not suitable for industrial production; in addition, a method for adopting lime water wastes time. In order to overcome the defects in the prior art, the invention adopts the technical scheme that the method for extracting bergenin from traditional Chinese medicine rodgersia podophylla comprises the following steps: taking traditional Chinese medicine rodgersia podophylla coarse powder as raw material; carrying out reflux extraction on the raw material for 3 times by alcohol of which the amount is 4-6 times of that of the raw material, wherein the first time lasts for 1-3 hours, and the second time and the third time respectively last for 0.5-1.5 hours; collecting extract, precipitating and filtering; recovering filtrate, and condensing to small volume; standing for devitrification; after the devitrificated crystal is dissolved by alcohol-carbinol mixed liquid at the volume ratio of 8:1-8:3, carrying out hot filtering; and after filtering, standing for devitrification. The method has simple technology, low cost, available raw material and high extraction efficiency and is favorable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical research of traditional Chinese medicines, and in particular relates to a method for extracting petracenin from the Chinese medicinal material Guidenghua. Background technique [0002] Begenin (C 14 h 10 o 9 ), also known as petroglyphate and bergamot, petracenin has a wide range of resources and exists in five families and nine genera of plants. The Pharmacopoeia of the People's Republic of China is included as an antitussive and expectorant drug for the treatment of chronic bronchitis. A variety of compound preparations using petracenin as raw materials have been used clinically. In addition, petracenin can also provide raw materials for reference substances in traditional Chinese medicine testing. In addition, it has been reported in the literature that petracenin has anti-inflammatory and analgesic effects. A variety of medicinal plants contain petracenin, but the content varies. In the prior art,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04
Inventor 罗定强
Owner 罗定强
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