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Method for detecting active ingredient content of Yushangling capsules

A technology of active ingredients and Yushangling, applied in the field of modern quality control, can solve the problems of inability to guarantee curative effect, inability to control the content of active ingredients in finished products, and inability to control whether the active ingredients of medicinal materials are lost, etc., to achieve the effect of guaranteeing curative effect

Inactive Publication Date: 2008-04-02
JINZHOU AHON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process of Chinese patent medicine goes through many processes (drying, frying, crushing, etc.), and it is impossible to control whether the active ingredients in the medicinal materials are lost during the production process, so qualified Chinese medicinal materials may not be able to produce qualified and effective products
However, the existing general standards only conduct qualitative analysis on the finished product, and cannot control the content of active ingredients in the finished product and cannot guarantee the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1, determination Yushangling capsule active ingredient content

[0016] 1) Instruments and reagents

[0017] Shimadzu LC-10AT VP liquid chromatograph; Class VP5.03 chromatographic workstation; ultrasonic cleaner KQ-250BKUN Kunshan Ultrasonic Instrument Factory; batch number of petracenin reference substance: (0703-200020), purchased from China Pharmaceutical Biological Products Laboratory; acetonitrile and methanol are HPLC grade.

[0018] 2) Chromatographic conditions

[0019] Chromatographic column: Hypersil ODS, 4.6×200mm (sn US41E08619), with octadecyl bonded silica gel as filler; methanol-water (22:78) as mobile phase; flow rate: 0.9ml / min; detection wavelength: 275nm , the number of theoretical plates should not be less than 4000 based on the peak of petogenin.

[0020] 3) Preparation of solution

[0021] Preparation of reference substance solution: Accurately weigh 10 mg of petracenin reference substance, place it in a 10ml volumetric flask, dissol...

Embodiment 2

[0032] Embodiment 2, the accuracy test of detection method of the present invention

[0033] 1. Prescription of Yushangling Capsules:

[0034] Panax notoginseng 180g safflower 120g Cucumber seeds (stir-fried) 120g

[0035] Ground Beetle 60g Angelica 90g Natural Copper (Calcined) 30g

[0036] Borneol 12g Dipsacus 60g Astilbe 50.4g

[0037] Makes 2408 capsules

[0038] All the required Chinese herbal medicines were purchased from Hebei Anguo Chinese herbal medicine market.

[0039] 2. Production process: (except for special instructions in the process, all are routine operations)

[0040] 1) Accurately weigh Panax notoginseng, safflower, angelica, Dipsacus, and astilbe five herbs according to the prescription amount, mix and pulverize the coarse powder, add 70% ethanol to reflux, add 6 times the amount of ethanol for the first time, extract for 2 hours, second, Add 3 times the amount of ethanol for the third time, extract each for 2 hours, let stand, filter, combine the fil...

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PUM

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Abstract

The invention discloses a method for detecting active ingredient content in Yushangling Capsule, including the following steps: (1) reference substance solution is prepared; (2) testing substance solution is prepared; (3) standard curve is drawn; (4) the active ingredient content in Yushangling Capsule is measured. The invention screens the active ingredient content in Yushangling Capsule through lots of experiments; moreover, the invention screens the method for extracting bergenin from made medicine of Yushangling Capsule and ensures that the bergenin is suitable for high efficient liquid phase chromatogram detection after technical treatment; meanwhile, conditions for chromatogram detection are established. The method can effectively detect the active ingredient content in Yushangling Capsule and can effectively control product quality to ensure curative effect of product; therefore, the method can be widely used in production control in pharmaceutical factory.

Description

technical field [0001] The invention relates to a modernized quality control method of traditional Chinese medicine, in particular to a method for detecting the content of active ingredients in Yushangling capsules. Background technique [0002] Yushangling Capsule is a traditional Chinese medicine preparation, which has the effects of promoting blood circulation and dispelling blood stasis, reducing swelling and relieving pain; it is used for the treatment of bruises, blood stasis, swelling and pain of muscles and bones, and can also be used as an adjuvant treatment for fractures. At present, there are more than a dozen domestic enterprises producing this product, and the manufacturers all adopt traditional standards to control product quality, and only conduct qualitative analysis, not quantitative analysis. Since the quality of Chinese patent medicines is closely related to the quality of Chinese herbal medicines, the curative effect depends on the content of the main act...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/60G01N30/26
Inventor 王洪新杨菁宿希武
Owner JINZHOU AHON PHARM CO LTD
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