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Compound bergenin pills and its preparation method

A technology of petracenin and rock cabbage, which is applied in the field of drugs for the treatment of chronic bronchitis and cold and cough, and can solve the problems of slow dissolution, low bioavailability, and affecting the best efficacy

Inactive Publication Date: 2006-07-12
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that petracenin is a water-insoluble drug, and the tablet made by the general pulverization process dissolves slowly in the human body and has low bioavailability, which affects the best efficacy.
Therefore, how to improve the bioavailability of petracenin preparations after oral administration is an important problem in this field, which has not been solved so far.

Method used

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  • Compound bergenin pills and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: Get 30 parts of petracenin, 0.48 parts of chlorpheniramine, 269.52 parts of PEG6000, and make the finished product of dripping pills containing 3 mg of petracenin according to the above-mentioned melting method.

Embodiment 2

[0035] Embodiment 2: Get 45 parts of petracenin, 0.72 parts of chlorpheniramine, 254.28 parts of PEG4000, and process according to the above-mentioned melting method to obtain the finished product of dripping pills containing 4.5 mg of petracenin.

Embodiment 3

[0036] Embodiment 3: Get 60 parts of petracenin, 0.96 parts of chlorpheniramine, 239.04 parts of PEG6000, and make the finished product of dripping pills containing 6 mg of petracenin according to the above-mentioned melting method.

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Abstract

The invention relates to a novel medicinal dosage for treating chronic bronchitis and common cold, and its preparing process, which comprises medicinal active constituents and medicinal auxiliary materials, wherein the active components of the medicament include Bergenin 8-42 wt% and chlorpheniramine 0.001-0.01 wt%, and balancing medicinal auxiliary materials.

Description

technical field [0001] The invention relates to a medicine for treating chronic bronchitis and cold and cough, especially the medicine in a new dosage form and a preparation method thereof. Background technique [0002] Petgenin is an extract of botanical medicine, which has antitussive and expectorant effects and can be used to treat chronic bronchitis. The curative effect is certain, but the onset time is slow. The main reason is that petracenin is a poorly water-soluble drug, and tablets made by general pulverization process dissolve slowly in the human body and have low bioavailability, thus affecting the best efficacy. Therefore, how to improve the bioavailability of petracenin preparations after oral administration is an important problem in this field, which has not been solved so far. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies in the prior art, and provide a compound lithenol dropping pill with high dis...

Claims

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Application Information

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IPC IPC(8): A61K31/4402A61K31/366A61K9/20A61P11/00A61P11/14
Inventor 陈庆党何国民宾燕
Owner YUNNAN BAIYAO GROUP
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