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Composition for resisting thrombus as well as preparation method and application thereof

A composition and antithrombotic technology, which can be used in drug combinations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve problems such as large side effects, achieve easy industrial production, good antithrombotic effect, Simple preparation method

Inactive Publication Date: 2018-07-10
NANJING SHENGNUO BIO TECH IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For a long time, people have been looking for drugs that can reduce side effects to prevent thrombotic diseases, and the existing antithrombotic drugs have relatively large side effects

Method used

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  • Composition for resisting thrombus as well as preparation method and application thereof
  • Composition for resisting thrombus as well as preparation method and application thereof
  • Composition for resisting thrombus as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The preparation method of the above antithrombotic composition is obtained by mixing all the raw materials of the composition according to the formula; the preparation method is simple, easy to operate, and can be produced on a large scale.

[0034] Preferably, the method for preparing the concentrated natto powder comprises: cooking soybeans, inoculating Bacillus natto, fermenting, beating, concentrating, purifying and drying. More preferably, the step of defatting and devitamin K2 is also included before the purification, that is, soybeans are used as raw materials, after picking, cleaning and cooking, inoculated with Bacillus natto for fermentation, beating, ultrafiltration, ultra-low temperature concentration, defatting and devitamin K2, purification (to remove solvent residue), spray-dried, powdered, and sieved.

[0035] Wherein, the inoculum amount of Bacillus natto is 1%-1.5%, and fermented at 35-37° C. for 18-24 hours after inoculation. The beating can homogeni...

Embodiment

[0043] 1. Animal testing

[0044] 1.1 Test material

[0045] 1.1.1 Animals

[0046] The Wistar hyperlipidemic model rats were selected for the study on the effect of reducing blood lipid.

[0047] 1.1.2 Drugs and reagents

[0048] Concentrated natto powder: origin Japan.

[0049] Skipjack elastin peptide: origin Japan.

[0050] Black bean skin powder: origin Japan.

[0051] Maltitol: Made in Japan.

[0052] Microcrystalline cellulose,: origin Japan.

[0053] Maltodextrin: Origin Japan.

[0054] Yeast β-glucan: Made in China. Angel Yeast Co., Ltd.

[0055] Magnesium stearate: Made in China. Anhui Shanhe Pharmaceutical Excipients Co., Ltd.

[0056] Red Yeast Rice: Made in China. Hangzhou Shuangma Biotechnology Co., Ltd.

[0057] All are commercially available products.

[0058] 1.2 Test settings

[0059] Composition is set as two factors, one for each factor. Group A is concentrated natto powder, bonito elastin peptide. Group B is maltitol, microcrystalline cell...

experiment example

[0086] When preparing concentrated natto powder, the steps of defatting and devitamin K2 were carried out to form the experimental group and the step of not performing defatted and devitamin K2 was used to form the control group, and they were used in conjunction with bonito elastin peptide to detect its blood lipid-lowering effect.

[0087] Rats were randomly divided into 6 groups, 12 in each group. They were divided into experimental group 1, experimental group 2, experimental group 3, control group 1, control group 2, and control group 3.

[0088] Experimental 1-3 groups and control 1-3 groups were formulated with distilled water suspension according to the weight of the mice according to the equivalent composition in Table 5, and administered intragastrically. The time is 1:00 pm each day. One hour after the last day of administration, blood was collected from the retro-orbital venous plexus of the mice at room temperature, and about 1.5 mL of blood was collected, centrif...

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Abstract

The invention provides a composition for resisting a thrombus as well as a preparation method and application thereof, and belongs to the technical field of biology. The composition for resisting thethrombus is prepared from the following raw materials in parts by weight: 10 to 40 parts of concentrated natto powder and 1 to 10 parts of skipjack elastic protein peptide. The composition for resisting the thrombus is obtained by mixing the concentrated natto powder and the skipjack elastic protein peptide. The application of the composition prepared by the preparation method in the preparation of a thrombus-resisting medicine, a health product or food such as new-resource food is wider, and the composition is healthy and safe, has no toxic and side effects, is good in thrombus resisting effect, moreover, can be used for reducing blood fat, and is used for increasing the immunologic function of a patient.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an antithrombotic composition, its preparation method and application. Background technique [0002] Thrombotic disease is a serious threat to human life and health, and its incidence rate ranks first among various diseases. Its etiology and pathogenesis are very complex and have not been fully elucidated so far. Currently, abnormal platelet function and vascular endothelial cell damage are considered to be important factors for thrombosis. Thrombosis is one of the main pathogenic factors of heart and brain ischemic diseases. Studies have shown that during cerebral ischemia, platelet function is abnormally hyperactive and blood is in a hypercoagulable state, which is one of the important causes of secondary brain damage. Visible , the activation and aggregation of platelets play an important role in thrombus formation. [0003] For a long time, people have been looking for drugs tha...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K36/48A61K36/899A61K47/36A61K47/12A61P7/02A61P3/06A23L33/105A23L33/18A23L33/125A61K31/716A61K36/062
CPCA61K36/899A61K38/012A61K47/12A61K47/36A23L33/105A23L33/125A23L33/18A61K31/716A61K36/062A61K36/48A23V2002/00A61K2236/19A61K2300/00A23V2200/3262A23V2200/326
Inventor 王庆军李卓杜显龙孙雨薇孟凡莉郭婉
Owner NANJING SHENGNUO BIO TECH IND
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