Multi-effect cream capable of promoting skin fibroblasts to secrete structural proteins

A cream and elastin technology, applied in skin care preparations, cosmetics, cosmetic preparations, etc., can solve the problems of being easily damaged by enzymes, bacteria and even body fluids, high in vivo clearance rate, and low bioavailability, etc. Stability and penetration, wrinkle reduction, shelf life extension

Inactive Publication Date: 2020-01-10
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because protein and polypeptide drugs need to maintain the chemical structure of protein molecules to maintain their activity, they have poor stability, short half-life, poor membra

Method used

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  • Multi-effect cream capable of promoting skin fibroblasts to secrete structural proteins
  • Multi-effect cream capable of promoting skin fibroblasts to secrete structural proteins
  • Multi-effect cream capable of promoting skin fibroblasts to secrete structural proteins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The multi-effect cream is prepared by the above preparation method, which is prepared from the following parts by weight of raw materials: 181 parts of water, 0.5 parts of carbomer, 12.5 parts of glycerin, 1.5 parts of allantoin, 15 parts of mineral oil, and propyl paraben 0.25 parts of ester, 0.25 parts of methyl paraben, 0.45 parts of polydimethylsiloxane, 12.5 parts of cetostearyl alcohol, 0.1 part of flavor, 21.5 parts of elastin peptide liposome solid freeze-dried product, 1.5 parts of tocopherol glycoside Parts, 0.25 parts of borneol, 2.8 parts of glyceryl stearate, 1.3 parts of Tween 20, 7.5 parts of propylene glycol, 10 parts of shea butter, 0.5 parts of disodium ethylenediaminetetraacetic acid and an appropriate amount of aminomethyl propanol.

Embodiment 2

[0050] The preparation method of the multi-effect cream in this example is the same as that in Example 1, except that it is prepared from the following parts by weight: 173 parts of water, 0.3 parts of carbomer, 13 parts of glycerin, and 1 part of allantoin , 14 parts of mineral oil, 0.2 parts of propyl paraben, 0.2 parts of methyl paraben, 0.5 parts of polydimethylsiloxane, 14 parts of cetostearyl alcohol, 0.1 parts of flavor, elastin peptide liposome solid jelly 22 parts of dry product, 1.2 parts of tocopherol glycosides, 0.15 parts of borneol, 2.7 parts of glyceryl stearate, 1 part of Tween 20, 8 parts of propylene glycol, 10 parts of shea butter, 0.4 parts of disodium ethylenediaminetetraacetic acid and Amount of aminomethyl propanol.

Embodiment 3

[0052] The preparation method of the multi-effect cream in this example is the same as that in Example 1, except that it is prepared from the following parts by weight: 185 parts of water, 0.6 parts of carbomer, 14 parts of glycerin, 1.5 parts of allantoin , 17 parts of mineral oil, 0.2 parts of propyl paraben, 0.3 parts of methyl paraben, 0.5 parts of polydimethylsiloxane, 14 parts of cetostearyl alcohol, 0.08 parts of flavor, elastin peptide liposome solid jelly 22 parts of dry product, 1.1 parts of tocopherol glycosides, 0.20 parts of borneol, 2.9 parts of glyceryl stearate, 1.4 parts of Tween 20, 8 parts of propylene glycol, 9 parts of shea butter, 0.4 parts of disodium ethylenediaminetetraacetic acid and Amount of aminomethyl propanol.

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PUM

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Abstract

The invention discloses a multi-effect cream capable of promoting skin fibroblasts to secrete structural proteins. The cream consists of, in parts by weight, 20-24 parts of elastin peptide liposome, 170-190 parts of water, 0.3-0.7 part of carbomer, 10-15 parts of glycerin, 1-2 parts of allantoin, 13-17 parts of mineral oil, 0.2-0.3 part of propyl hydroxybenzoate, 0.2-0.3 part of methyl hydroxybenzoate, 0.3-0.6 part of poly(dimethylsiloxane), 11-15 parts of cetostearyl alcohol, 0.07-0.1 part of essence, 0.8-1.5 parts of tocopheryl glycoside, 0.15-0.25 part of borneol, 2.5-3 parts of glyceryl monostearate, 1.0-1.5 parts of Tween 20, 6-9 parts of propylene glycol, 9-11 parts of shea butter, 0.4-0.6 part of ethylene diamine tetraacetic acid disodium salt and a proper amount of 2-amino-2-methyl-1-propanol. The elastin peptide liposome in the cream can be effectively absorbed by skins, so that the elasticity of facial skins can be recovered.

Description

Technical field [0001] The invention relates to the field of cosmetics, in particular to a multi-effect cream that promotes the secretion of structural proteins from skin fibroblasts. Background technique [0002] Skin elasticity is a problem that everyone faces. As we age, the loss of elastin is inevitable. Wrinkles due to lack of skin elasticity are one of the important skin problems that people are concerned about, and most of them are more effective in society. The method is surgery and prevention, and surgery is a method approved by a small number of people, and it is not very useful for people who have lost skin elasticity. [0003] In the prior art, by introducing elastin peptides into the cream, elastin peptide liposomes can directly enter the blood circulation of the face by promoting fibroblasts to produce elastin and collagen in the dermis of the skin, thereby restoring the skin to fullness. State of flexibility. However, because protein peptide drugs need to maintain ...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/06A61K8/14A61K8/34A61K8/37A61K8/44A61K8/49A61K8/64A61K8/67A61K8/81A61K8/891A61K8/86A61K8/55A61K8/63A61Q19/00A61Q19/06
CPCA61K8/64A61K8/8147A61K8/345A61K8/4946A61K8/37A61K8/891A61K8/678A61K8/44A61K8/922A61K8/375A61K8/34A61K8/86A61K8/553A61K8/63A61K8/4993A61K8/14A61K8/06A61Q19/06A61Q19/00
Inventor 吴文惠江涛王婷吴昊琦张达杰蔡旗朱翔宇
Owner SHANGHAI OCEAN UNIV
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